STUDY OF THE GENERAL TOXIC PROPERTIES OF THE ANTI-TB DRUG THIOSONIDE

The aim of the study was to evaluate the subchronic and chronic toxicity of the substance – thiosonide - in experiments on rabbits and rats. The animals received doses ranging from therapeutic to 75 times higher. The drug in studied doses did not cause any significant changes in body weight increase of animals, behavioral reactions, food and water consumption. There were no changes in the biochemical and cellular composition of peripheral blood, the protein-synthesizing function of the liver, carbohydrate metabolism, and the functional state of the cardiovascular system. In the work of the central nervous system, a slight decrease in motor activity was observed in male rats that were long-term treated with a drug substance in a dose of 100 mg/kg (more than 10 times higher than the therapeutic dose). A local irritant effect in the gastrointestinal tract of experimental rats was noted according to the results of histological studies, most pronounced under the influence of the drug at a dose of 100 mg/kg. According to the results of histological studies, minor dystrophic changes in the liver, kidneys and myocardium were found in some animals under the influence of a drug substance at a dose of 100 mg/kg. Thus, the active substance of the anti-tuberculosis drug does not have toxic properties that limit its long-term use, which allows us to consider it as a promising tool for inclusion in the basic long-term courses of treatment of the disease.

thiosonide, subchronic and chronic toxicity, rabbits, rats