CHANGES IN PROFILES OF BLOOD PLASMA FATTY ACIDS IN RATS CAUSED BY ADMINISTRATION OF SUB-LETHAL AMOUNTS OF ORGANOPHOSPHOROUS TOXIC AGENTS

Мұқаба

Дәйексөз келтіру

Толық мәтін

Аннотация

For the first time an investigation was conducted into the influence of sarin (GB), soman (GD) and Russian substance Vx (RVX) with and without application of antidotal preparations ( carboxin and carboxin mixed with atropine) on the qualitative and quantitative composition of free and etherified fatty acids at the level of ½LD50 (FFA and EFA correspondingly) in the blood plasma. Administration of GB and GD doses at the level of ½LD50 to rats causes a decrease of FFA in blood plasma after 3 hours. 24 hours later the FFA returns to the normal level. Administration of 2x0.4 LD50 RVX conditions an elevated level of FFA and EFA in the blood plasma throughout a week including enrichment of the FFA fraction with polyunsaturated acids. Antidotal therapy normalizes the FFA and EFA dynamics but does not prevent changes in their levels over first hours. Unlike organophosphorous pesticides, RVX at the level of ½LD50 inhibits acetyl cholinesterase but does not affect lipid exchange over first 24 hours.

Авторлар туралы

Anton Ukolov

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Хат алмасуға жауапты Автор.
Email: noemail@neicon.ru

Кандидат химических наук, старший научный сотрудник лаборатории аналитической токсикологии ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: AntonUkolov@gmail.com

Ресей

Tatyana Orlova

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru

Научный сотрудник лаборатории аналитической токсикологии ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: orlovatatianagpeh@mail.ru 

Ресей

Elena Savel

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru

Доктор химических наук, заведующий лабораторией аналитической токсикологии ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: ESavelieva59@mail.ru

Ресей

Andrey Radilov

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru

Доктор медицинских наук, профессор, заведующий отделом токсикологии, заместитель директора по научной работе ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: radilov@rihophe.ru

Ресей

Nikolay Goncharov

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: noemail@neicon.ru

Доктор биологических наук, ведущий научный сотрудник лаборатории аналитической токсикологии ФГУП «НИИГПЭЧ» ФМБА России, 188663, Ленинградская область

e-mail: ngoncharov@gmail.com 

Ресей

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© Ukolov A.I., Orlova T.I., Savel E.I., Radilov A.S., Goncharov N.V., 2015


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