Email this article ASSESSMENT OF THE TOXICITY AND HAZARD OF SODIUM LAURYL SULFATE AT DIFFERENT EXPOSURE ROUTES
- Authors: Bidevkina M.V.1, Golubeva M.I.2, Limantsev A.V.1, Razumnaya I.N.2, Potapova T.N.1, Fedorova E.A.2
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Affiliations:
- Scientifi c Research Institute of Disinfectology of Rospotrebnadzor
- Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»
- Issue: No 4 (2020)
- Pages: 56-59
- Section: New information on toxicity and hazard of chemical and biological substances
- Published: 31.07.2020
- URL: https://rjsvd.com/0869-7922/article/view/641267
- DOI: https://doi.org/10.36946/0869-7922-2020-4-56-59
- ID: 641267
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Abstract
Sodium lauryl sulfate is the most common surfactant used in the production of detergents, chloroprene rubber, plastics, artificial furs and in pharmaceutical industry. Sodium lauryl sulfate is a moderately hazardous substance when introduced into the stomach (DL50 for white mice and rats is in the range of 2086-2700 mg/kg), has a pronounced local irritant effect on the skin and mucous membranes of the eyes, has a skin-resorptive, sensitizing and pronounced cumulative effects. The threshold for acute inhalation action is set at 15,3 mg/m3 for changes in the function of the nervous system and irritating effects on the mucous membranes of the upper respiratory tract (an increase in the total number of cells in the nasal flushes).
Recommended for approval tentative safe exposure level of sodium lauryl sulfate in the air of the working area is 0.2+ mg/m3 (aerosol).
About the authors
M. V. Bidevkina
Scientifi c Research Institute of Disinfectology of Rospotrebnadzor
Author for correspondence.
Email: bidevkinamv@niid.ru
Bidevkina Marina Vasil’evna
117246, Moscow
Russian FederationM. I. Golubeva
Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»
Email: golubevamargo@mail.ru
Golubeva Margarita Ivanovna
142450, Staraya Kupavna
Russian FederationA. V. Limantsev
Scientifi c Research Institute of Disinfectology of Rospotrebnadzor
Email: av.lim@yandex.ru
Limantsev Anatoliy Vladimirovich
117246, Moscow
Russian FederationI. N. Razumnaya
Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»
Email: irina.r.3@mail.ru
Razumnaya Irina Nikolaevna
142450, Staraya Kupavna
Russian FederationT. N. Potapova
Scientifi c Research Institute of Disinfectology of Rospotrebnadzor
Email: potapovatn@niid.ru
Potapova Tat’yana Nikolaevna
117246, Moscow
Russian FederationE. A. Fedorova
Joint-Stock Company «All-Union Scientifi c Center for the Safety of Biologically Active Substances»
Email: emfed@mail.ru
Fedorova Emma Alexeevna
142450, Staraya Kupavna
Russian FederationReferences
- OECD; SIDS Initial Assessment Report for SIAM 5. Sodium dodecyl sulphate (CAS No: 151-21-3). – 2005 – p. 17-20. Available at: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+1315 (accsessed 07 June, 2019)
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