POTENTIAL DIRECTIONS OF THE IMPROVEMENT OF ANTIDOTE THERAPY OF CYANIDE POISONING

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Abstract

The article on the basis of an analysis of the literature discusses promising areas for the development of antidote prophylaxis and treatment of acute cyanide poisoning. The chemical compounds mediating anticyanide activity by stimulating the main detoxification mechanisms of endogenous cyanide: sulfangen, cobinamide, α-ketoglutaric acid claimed to be potential cyanide antidotes, effective and safe for intramuscular and intraosseous injections, inhalation and oral administration.

About the authors

V. D. Gladkikh

Research and Production Center “Pharmaceutical Protection”, Federal Medical Biological Agency

Author for correspondence.
Email: Gladkich2007@rambler.ru

Gladkikh Vadim Dmitrievich

141402, Khimki

Russian Federation

G. V. Vershinina

Research and Production Center “Pharmaceutical Protection”, Federal Medical Biological Agency

Email: vershinina@atompharm.ru

Vershinina Galina Vasilevna

141402, Khimki

Russian Federation

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Copyright (c) 2019 Gladkikh V.D., Vershinina G.V.


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