SCIENTIFIC BASIS OF HYGIENIC REGULATIONS OF PICOLINAPHENE CONTENT IN HUMAN ENVIRONMENT

Cover Page

Cite item

Full Text

Abstract

Based on the available literature data, a comprehensive toxicological and hygienic assessment of picolinaphene, a new little-studied active ingredient of plant protection products used for selective destruction of plants, has been carried out. According to the accepted classification, picolinaphene can be assigned to hazard class 3 (moderately hazardous compound) with the general toxic limiting sign. As a result of the assessment, the hygienic regulations of the active substance in the human environment are scientifically substantiated: the tentative safe level of exposure in the air of the working area is 0,6 mg/m3, the tentative safe level of exposure in the air (average daily) is 0,004 mg/m3, the tentative permissible level in the water of water bodies is 0,07 mg/dm3, the tentative permissible concentration in the soil is 0,4 mg/kg, the temporary allowable daily dose is 0,015 mg/kg, and the temporary maximum allowable level of residual amounts of picolinaphene in grain crops is 0,2 mg/kg.

About the authors

V. A. Hrynchak

Scientific Practical Centre of Hygiene, the Ministry of Health of the Republic of Belarus

Author for correspondence.
Email: grinchakva@gmail.com
220012, Minsk

Belarus

I. I. Ilyukova

Scientific Practical Centre of Hygiene, the Ministry of Health of the Republic of Belarus

Email: toxlab@mail.ru
220012, Minsk

Belarus

S. I. Sychik

Scientific Practical Centre of Hygiene, the Ministry of Health of the Republic of Belarus

Email: rspch@rspch.by
220012, Minsk Belarus

References

  1. Iljukova I.I., Hrynchak V.A., Anisovich M.V., Popel A.A., Vasileva M.M. Features of determining the equivalence of generic pesticide products. Health and the Environment. 228-225 :26 ;2016 (in Russian).
  2. Bjendzhel Briston L., Sachivi Norbert M. 2 Herbicidal compositions containing-4amino-3-chloro-4) -6-chloro-2-fluoro-3methoxyphenyl) -5-fluoropyridin-2-carboxylic acid or its derivatives and flurtamone, diflufenican or picolinafen. Patent RF, N 2018 ;2644180 (in Russian).
  3. Haker Jervin, Biringer Hermann, Huff Hans Filipp. Synergistic herbicidal combination and weed control method. Patent RF, N 2009 ;2344601 (in Russian).
  4. Korshun O.M., Lipavskaja A.A., Rudaja T.V. Analytical support of hygienic control over the use of picolinafen based herbicides. Naukovij ogljad. 15 ;2015 53-46 :(5) (in Russian).
  5. Unified sanitary-epidemiological and hygienic requirements for goods subject to sanitary-epidemiological supervision (control). Chapter II, sect. 15. Requirements for pesticides and agrochemicals: 1070–983 (in Russian).
  6. Vlasenko E.K., Sychik S.I. Methodological aspects of toxicological and hygienic assessment of plant growth regulators. Tr. Belorus. gos. un-ta. Fiziol., biohim. i molekuljar. osnovy funkcionirovanija biosistem. 11 ;2016 63–42 :(1) (in Russian).
  7. Kozhuro Ju.I., Anisovich M.V., Afonin V.Ju. The effect of triazine herbicides simazin and semeron on the cells of the leukocyte series of poikilothermic animals. Vesti BGU. Serija :2 ;2014 .2 44-40 (in Russian).
  8. Vlasenko E.K., Hrynchak V.A., Popel A.A., Kisel M.A. Scientific substantiation of the maximum allowable levels of -5aminolevulinic acid hexyl ester in food raw materials and the development of methods for its determination in human environment. Health and the Environment. 221–217 :26 ;2016 (in
  9. Russian).
  10. Vlasenko E.K., Stelmah V.A., Iljukova I.I., Kremko L.M., Hrynchak V.A. Scientific substantiation of a number of hygienic regulations for the content of -5aminolevulinic acid hexyl ester in the human environment. Health and the Environment. 87–82 :(2) 25 ;2015 (in Russian).
  11. Vlasenko E.K., Stelmah V.A., Iljukova I.I., Kremko L.M., Hrynchak V.A. Scientific substantiation of a number of hygienic regulations for the content of -5aminolevulinic acid hexyl ester in the human environment. Health and the Environment. 87–82 :(2) 25 ;2015 (in Russian).
  12. Guideline № 2004–35–12–1.1.11. Requirements for the setting up of experimental studies for initial toxicological assessment and hygienic regulation of substances. Minsk, 2004 (in Russian).
  13. Guideline № 2004–35–12–1.1.11. Requirements for the setting up of experimental studies for initial toxicological assessment and hygienic regulation of substances. Minsk, 2004 (in Russian).
  14. Methodical recommendations № 0010-118. Experimental substantiation and calculation of footwear of harmful substances in the air of the working area. Minsk, 2010 (in Russian).
  15. Methodical recommendations № 0010-118. Experimental substantiation and calculation of footwear of harmful substances in the air of the working area. Minsk, 2010 (in Russian).
  16. Guidelines for decision on tentatively safe exposure levels (SLE) and hazard class of pollutants in the atmospheric air of populated areas № 97-2-7-11. Minsk, 1998 (in Russian).
  17. Guidelines for decision on tentatively safe exposure levels (SLE) and hazard class of pollutants in the atmospheric air of populated areas № 97-2-7-11. Minsk, 1998 (in Russian).
  18. Guidelines for the use of calculation and express experimental methods in hygienic regulation of chemical compounds in water of reservoirs № 78-1943. M., 1979 (in Russian).
  19. Guidelines for the use of calculation and express experimental methods in hygienic regulation of chemical compounds in water of reservoirs № 78-1943. M., 1979 (in Russian).
  20. Methodical recommendations № 0010-127. Accelerated hygienic regulation of exogenous chemicals in the soil. Minsk, 2000 (in Russian).
  21. Methodical recommendations № 0010-127. Accelerated hygienic regulation of exogenous chemicals in the soil. Minsk, 2000 (in Russian).
  22. Guidelines for hygienic assessment of new pesticides № 87-4263. Kiev, 1988 (in Russian).
  23. Guidelines for hygienic assessment of new pesticides № 87-4263. Kiev, 1988 (in Russian).
  24. Pest Management Regulatory Agence de reglementation de la antiparasitaire Regulatory Note REG2003) 02-2003). Available at: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&ved=2ahUKEwiY5NDJpevkAhUJy6YKHRVfCk4QFjAEegQIBRAC&url=https3%A2%F2%Fwww.fluoridealert.org2%Fwp-content2%Fpesticides2%Fpicolinafen.canada.feb.2003.pdf&usg=AOvVaw1tiZqLIET_K3ES5yU8cbp4 (accessed 24 September 2019).
  25. Pest Management Regulatory Agence de reglementation de la antiparasitaire Regulatory Note REG2003) 02-2003). Available at: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=5&ved=2ahUKEwiY5NDJpevkAhUJy6YKHRVfCk4QFjAEegQIBRAC&url=https3%A2%F2%Fwww.fluoridealert.org2%Fwp-content2%Fpesticides2%Fpicolinafen.canada.feb.2003.pdf&usg=AOvVaw1tiZqLIET_K3ES5yU8cbp4 (accessed 24 September 2019).
  26. Evaluation of the new active PICOLINAFEN in the products SNIPER HERBICIDE & PARAGON HERBICIDE (2000). Available at: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&ved=2ahUKEwjdxfbW6O3kAhUKCZoKHcjQDWEQFjAFegQIARAC&url=https3%A2%F2%Fapvma.gov.au2%Fsites2%Fdefault2%Ffiles2%Fpublication2%F-13896prs-picolinafen.pdf&usg=AOvVaw1k2bKl1m4YqagoFjtq9jh (accessed 23 September 2019).
  27. Evaluation of the new active PICOLINAFEN in the products SNIPER HERBICIDE & PARAGON HERBICIDE (2000). Available at: https://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=6&ved=2ahUKEwjdxfbW6O3kAhUKCZoKHcjQDWEQFjAFegQIARAC&url=https3%A2%F2%Fapvma.gov.au2%Fsites2%Fdefault2%Ffiles2%Fpublication2%F-13896prs-picolinafen.pdf&usg=AOvVaw1k2bKl1m4YqagoFjtq9jh (accessed 23 September 2019).
  28. State Standard 76-12.1.007. Harmful substances. Classification and general safety requirements. Minsk: Standartinform Publ., 2008 (in Russian).
  29. State Standard 76-12.1.007. Harmful substances. Classification and general safety requirements. Minsk: Standartinform Publ., 2008 (in Russian).
  30. The methodology for determining picolinafen, the active substance of the drug «MARAFON PLUS, KS» in water, soil, air of the working area, plant materials by high performance liquid chromatography No. 17/2381/02-10/379. Minsk, 2019 (in Russian).
  31. The methodology for determining picolinafen, the active substance of the drug «MARAFON PLUS, KS» in water, soil, air of the working area, plant materials by high performance liquid chromatography No. 17/2381/02-10/379. Minsk, 2019 (in Russian).

Supplementary files

Supplementary Files
Action
1. JATS XML
Download

Copyright (c) 2019 Hrynchak V.A., Ilyukova I.I., Sychik S.I.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ПИ № ФС 77 - 81728 от 11 декабря 2013.