Email this article EXPERIMENTAL SUBSTANTIATION OF THE MAXIMUM ALLOWABLE CONCENTRATION OF DIOCTYL TEREPHTHALATE IN THE AIR OF THE WORKING AREA
- Authors: Radilov A.S.1, Solntseva S.A.1, Shkaeva I.E.1, Dulov S.A.1, Vivulanets E.V.1, Protasova G.A.1, Shabasheva L.V.1, Nikulina O.S.1
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Affiliations:
- Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
- Issue: No 1 (2020)
- Pages: 34-38
- Section: Articles
- Published: 24.02.2020
- URL: https://rjsvd.com/0869-7922/article/view/641204
- DOI: https://doi.org/10.36946/0869-7922-2020-1-34-38
- ID: 641204
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Abstract
Toxicity and hazard assessment of dioctyl terephthalate (DOTP) was performed in acute, subacute, and chronic experiments, and its principal toxicometry parameters were determined.
It was found that on single exposure DOTP exhibits low toxicity and hazard. No resorptive and irritant effects on skin and mucous membrane of eyes were detected in animal experiments. The single inhalation exposure threshold limit value was set at 300 mg/m3, based on the results of monitoring of the functional state of the central nervous system and myocardium and hematological parameters.
Thirty-day subacute experiments (oral administration, inhalation exposure, and skin applications) revealed no accumulation of the compound.
Four-month chronic exposure to DOTP aerosols (concentration 96,8 mg/m3) caused disorder of the functional state of the central nervous system and myocardium, changes in the hematological and biochemical parameters, gas and acid-base status of the blood, and morphological changes in the lungs and heart. Embryotoxic, genotoxic and gonadotoxic effects were not detected.
The chronic inhalation exposure threshold limit value for DOTP (Limch) was set at 18,6 mg/m3, and the concentration of 3,4 mg/m3 was found to be ineffective.
The maximum allowable concentration of DOTP in the air of the working area was set at 3,0 mg/m3, hazard class 3.
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About the authors
A. S. Radilov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Author for correspondence.
Email: niigpech@rihophe.ru
188663, Kuzmolovsky, Leningrad region
Russian FederationS. A. Solntseva
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Email: fake@neicon.ru
188663, Kuzmolovsky, Leningrad region
Russian FederationI. E. Shkaeva
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Email: ieshkaeva@list.ru
188663, Kuzmolovsky, Leningrad region
Russian FederationS. A. Dulov
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Email: fake@neicon.ru
188663, Kuzmolovsky, Leningrad region
Russian FederationE. V. Vivulanets
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Email: fake@neicon.ru
188663, Kuzmolovsky, Leningrad region
Russian FederationG. A. Protasova
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Email: fake@neicon.ru
188663, Kuzmolovsky, Leningrad region
Russian FederationL. V. Shabasheva
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Email: fake@neicon.ru
188663, Kuzmolovsky, Leningrad region
Russian FederationO. S. Nikulina
Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency
Email: fake@neicon.ru
188663, Kuzmolovsky, Leningrad region
Russian FederationReferences
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