MULTI-CHAMBER MODEL AS AN INSTRUMENT FOR ANALYSIS OF THE TOXICOKINETIC ROLE OF SOLUBILITY OF ELEMENT OXIDE NANOPARTICLES AND PHAGOCYTIC REACTION TO THEIR DEPOSITION IN LUNGS IN CHRONIC INHALATION EXPOSURE

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Abstract

The paper retraces the development of a mechanistic multi-chamber model describing particle retention in lungs in chronic inhalation exposures. This model was first developed and experimentally tested for various conditions of exposure to polydisperse dusts of SiO2 or TiO2, and later successfully used as a basis for analyzing patterns in the retention of nanoparticles (NP) having different chemical compositions (Fe2O3, SiO2, NiO). The most significant adaptation of this model for exposure to element oxide NPs was due to the need to take into account not only the physiological mechanisms of their elimination, but also their solubility «in vivo». It has been found that the relative contribution of the latter might be different for nanoparticles of different nature and predominant in some cases. The modeling of NiO-NPs retention also suggests that damage to the physiological pulmonary clearance mechanisms by particularly toxic nanoparticles might result in lung toxicokinetics becoming nonlinear.

About the authors

B. A. Katsnelson

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the Rospotrebnadzor

Author for correspondence.
Email: bkaznelson@etel.ru
Katsnelson Boris Aleksandrovich Russian Federation

M. P. Sutunkova

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the Rospotrebnadzor

Email: sutunkova@ymrc.ru
Sutunkova Marina Petrovna Russian Federation

L. K. Konysheva

Ekaterinburg Theological Seminary

Email: konkl@yandex.ru

Konysheva Ludmila Konstantinovna

Russian Federation

S. N. Solovyeva

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the Rospotrebnadzor

Email: solovyevasn@ymrc.ru

Solovyeva Svetlana Nikolaevna

Russian Federation

I. A. Minigalieva

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the Rospotrebnadzor

Email: ilzira@ymrc.ru
MinigalievaIlziraAmirovna Russian Federation

V. B. Gurvich

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the Rospotrebnadzor

Email: gurvich@ymrc.ru
GurvichVladimirBorisovich Russian Federation

L. I. Privalova

Ekaterinburg Medical Research Center for Prophylaxis and Health Protection in Industrial Workers of the Rospotrebnadzor

Email: privalova@ymrc.ru

Privalova Larissa Ivanovna

Russian Federation

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Copyright (c) 2019 Katsnelson B.A., Sutunkova M.P., Konysheva L.K., Solovyeva S.N., Minigalieva I.A., Gurvich V.B., Privalova L.I.


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