TOXICITY AND HAZARD OF PHTHALATES (Literature review)

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Abstract

The analysis of literature data on toxicity and hazard of phthalic acid derivatives is carried out. It is shown that phthalates are widely used in various industries as plasticizers. With a single intake, phthalates, as a rule, are lowtoxic and low-hazard substances. Repeated exposure to these compounds leads to their accumulation in the body, having a polytropic effect with damage to the liver, kidneys, lungs, as well as embryotoxic and gonadotoxic effect. It is shown that the studied phthalates are dangerous for workers exposed to aerosols in the air of industrial premises. Based on the results of the analysis and summary of the literature, the following main conclusions are made. For an objective assessment of the danger of phthalic acid derivatives it is necessary to study the toxic effect of these compounds in subacute and chronic experiments. Establishing a hazard class for phthalates based only on the study of acute toxicity can lead to wrong conclusions with negative consequences for the health and lives of staff and the public.

About the authors

I. E. Shkaeva

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Author for correspondence.
Email: ieshkaeva@list.ru
188663, Saint Petersburg

Russian Federation

S. A. Solntseva

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: fake@neicon.ru
188663, Saint Petersburg Russian Federation

O. S. Nikulina

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: fake@neicon.ru
188663, Saint Petersburg Russian Federation

A. I. Nikolaev

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: fake@neicon.ru
188663, Saint Petersburg Russian Federation

S. A. Dulov

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: niigpech@rihophe.ru
188663, Saint Petersburg Russian Federation

A. V. Zemlyanoy

Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency

Email: fake@neicon.ru
188663, Saint Petersburg Russian Federation

References

  1. Danishevskiy S.L. Esters. In: Hazardous Substances in Industry. Leningrad: Khimiya; 1971; vol. 1: 480–482 (in Russian).
  2. RTECS(R) National Institute for Occupational Safety and Health. Canadian Centre for Occupational Health Safety; 2005.
  3. Sheftel V.O., Dyszynevich N.E., Sova R.E. Toxicology of Polymer Materials. Kiev: Zdorov’e; 1988 (in Russian).
  4. Heudorf U., Mersch-Sundermann V., Angerer J. Phthalates: toxicology and exposure. Int. J. Hygiene Environ Health. 2007; 210 (5): 623 – 634.
  5. HS 2.2.5.3532-Maximum Allowable Concentration (MAC) of Pollutants in Workplace Air. – Мoscow, 2018 (in Russian).
  6. HS 2.2.5.2308-Tentative Safe Exposure Levels (TSEL) of Pollutants in Workplace Air. – Мoscow; 2008 (in Russian).
  7. HS 2.1.6.2309-Tentative Safe Exposure Levels (TSEL) of Pollutants in the Atmospheric Air of Populated Areas. – Мoscow; 2008 (in Russian).
  8. Barshtein R.S., Kirilovich V.I., Nosovskiy Yu.E. Plasticizers for Polymers. Moscow: Khimiya; 1982 (in Russian).
  9. Maistenko V.N., Klyuev N.A. Ecological and Analytical Monitoring of Persistent Organic Pollutants. Moscow: Binom; 2012 (in Russian).
  10. Encyclopedia of Occupational Safety and Health, Pochinok, A.P., ed. Moscow: Min. Trudа Sots. Razvitiya, 2001, vol. 4 (in Russian).
  11. Sanina Yu.P., Kochetkova T.A. On the Toxicity of Dimethyl Terephthalate. In: Toxicology of New Industrial Substances, Letavet AA, ed. Moscow: Medgiz; 1963: 107−22 (in Russian).
  12. Bosnir J., Puntaric D. Migration of phthalates from plastic containers into soft drinks and mineral waters. Food Technol. Biotechnol. 2007; 145 (1): 91- 95.
  13. Woodward K.N. Phthalate Esters: Toxicity and Metabolism. Boca Raton, Florida: CRC Press; 1988.
  14. Hauser R. Phthalates and human health. Occup. Environ Med. 2005; 62 (11): 806 - 18.
  15. Lopez-Carrillo L., Hernandez-Ramirez R.U. Exposure to phthalates and breast cancer risk in northern Mexico. Environ. Health Perspect. 2010;118 (4): 539 - 44.
  16. Guo Y., Alomirah H., Cho H.- S. Occurrence of Phthalate metabolites in human urine from several Asian countries. Environ. Sci. and Technol. 2011; 45 (7): 3138 - 3144.
  17. Halden Rolf U. Plastics and health risks. Ann. Rev. Public Health. 2010; 31: 179 - 94.
  18. Kevy S.V., Jacobsen M.S. Hepatic effects of a phthalate ester plasticizer Leached from poly(vinyl chloride) blood bags following transfusion. Environ. Health Perspect. 1982; 45: 57- 64.
  19. Mylchreest E., Cattley R.C. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n- butyl) phthalate: an antiandrogenic mechanism, Toxicol. Science. 1998; 43: 47 - 60.
  20. Mylchreest E., Wallace D.G. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di(n-butyl) phthalate during late gestation. Tox. Sci. 2000; 55: 143 - 51.
  21. Koreneva E.M., Karpenko N.A., Kazak V.A. Exogenous Factors of Hypofertility. Components of Plastics —Phthalates. Reprod. Endokrin., 2011; 2: 62–67.
  22. Lowekamp-Swan T., Davis B. J. Mechanisms of Phthalate ester toxicity in the female reproductive system. Environ Health Perspect. 2003; 111 (2): 139 – 145.
  23. Aldyreva M.V., Klimova T.S., Izyumova A.S., Timofievskaya L.A. Effect of Phthalate Plasticizers on the Reproductive Function. Prof. Zdorov’e Prof. Zabolevaniya. 1975; 12: 25–29 (in Russian).
  24. Timofievskaya L.A. Biological Effect and Toxicity of o-Phthalic Esters. Moscow: NIITEkhim; 1981 (in Russian).
  25. Klimisch H.J., Hellwig J., Kaufmann W. Di-(2-ethylhexyl) phthalate (DEHP): Investigation of inhalation toxicity in rats after repeated exposure (28d). Human Exp. Toxicol. 1991; 10: 68.
  26. Jaeger R.J., Rubin R.J. Extraction, localization and metabolism of di-2-ethylhexyl phthalate from PVC plastic medical devices. Environ. Health. 1973; 3: 95 – 102.
  27. Rubin R., Chang J. Effect of the intravenous administration of the solubilizedplasticizer di(2-ethylhexyl)phthalate on the lung and on survival of transfused rats. Toxicol. Appl. Pharmacol. 1978; 45: 230.
  28. Cimini A.M., Sulli A., Stefanini S., Serafini B., Moreno S., Rossi L. [et al.]. Effects of di(2-ethylhexyl)phthalate on peroxisomes of liver, kidney, and brain of lactating rats and their pups. Cell. Mol. Biol. 1994; 40: 1063 – 76.
  29. David R.M., Moore M.R., Finney D.C., Guest D. Chronic toxicity of di(2-ethylhexyl) phthalate in rats. Toxicological Sciences. 2000; 55: 433 – 43.
  30. David R.M., Moore M.R., Finney D.C., Guest D. Chronic toxicity of di(2-ethylhexyl) phthalate in mice. Toxicological Sciences. 2000; 58: 377 – 85.
  31. Rao M.S., Yeldandi A.V., Subbarao V. Quantitative analysis of hepatocellular lesions induced by di(2-ethylhexyl)phthalate in F-344 rats. Toxicol. Environ. Health. 1990; 30: 85 – 89.
  32. Daniel J.W., Bratt H. The absorption, metabolism and tissue distribution of di-(2-ethylhexyl)phthalate in rats. Toxicol. 1974; 2: 51 – 65.
  33. Tyl R.W., Price C.J., Marr M.C., Kimmel C.A. Developmental toxicity evaluation of
  34. ietary di(2-ethylhexyl)phthalate in Fischer 344 rats and CD-1 mice. Fundam. Appl. Toxicol. 1988; 10: 395 – 412.
  35. Shaffer C.B., Carpenter C.P., Smyth H.J. Acute and subacute toxicity of di(2-ethylhexyl) phthalate with note upon its metabolism. Ind. Hyg. Toxicol. 1945; 27: 130 – 135.
  36. Lake B.G., Gray T. J., Foster J. R., Stubberfield C. R., Gangolli S. D. Comparative studies on di-(2-ethylhexyl)phthalate-induced hepatic peroxisome proliferation in the rat and hamster. Toxicol. Appl. Pharmacol. 1984b; 72: 46 – 60.
  37. Bui T.T., Giovanoulis G., Cousins A.P., Magnйr J., Cousins I.T., de Wit C.A. Human exposure, hazard and risk of alternative plasticizers to phthalate esters. Science of The Total Environment. 2016; 541: 451 – 67.
  38. Kwon B., Kyunghee J. Estrogenic and Androgenic Potential of Phthalates and Their Alternatives. Korean Journal of Environmental Health Sciences. 2016; 42 (3): 169 – 88.

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Copyright (c) 2019 Shkaeva I.E., Solntseva S.A., Nikulina O.S., Nikolaev A.I., Dulov S.A., Zemlyanoy A.V.


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