Email this article EFFECT OF POLYMORPHISM OF THE GABRA2 GENE ON THE DEGREE OF RAT POISONING IN ACUTE ETHANOL INTOXICATION
- Authors: Osechkina N.S.1, Nazarov G.V.1, Ivanov M.B.2, Batotsyrenova E.G.2, Kashuro V.A.2, Lapina N.V.2, Varlamova O.V.1, Kravtsov I.S.1, Babkin A.V.1, Kraeva A.S.1, Melekhova A.S.2, Voitsekhovich K.O.2, Lisitskii D.S.2
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Affiliations:
- Scientific Center «Signal»
- Institute of Toxicology, Federal Medical Biological Agency
- Issue: No 3 (2019)
- Pages: 3-7
- Section: Articles
- Published: 28.06.2019
- URL: https://rjsvd.com/0869-7922/article/view/641166
- DOI: https://doi.org/10.36946/0869-7922-2019-3-3-7
- ID: 641166
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Abstract
Four polymorphic GABRA2 gene variations: rs105733011, rs8168342, rs198286814, rs198837638 that can influence the formation of different biological effects of the organism when exposed to ethanol have been investigated. For rs105733011 polymorphism the frequency of occurrence of the CT genotype was found to be significantly higher (p < 0,05) among animals with «severe intoxication» – 37,0% than with «mild intoxication» – 14,0%. For rs198286814 polymorphism the tendency to the most frequent occurrence of the AG genotype in the group of animals with «severe intoxication» was established. Significant differences in the distribution of occurrence frequencies of the GG/AG genotypes in the studied groups for polymorphic loci rs8168342 and rs198837638 were not revealed. It was concluded that the rs105733011 polymorphism can be one of the genetic markers allowing to predict the degree of inhibitory action of ethanol in acute alcohol intoxication.
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About the authors
N. S. Osechkina
Scientific Center «Signal»
Author for correspondence.
Email: dunats@rambler.ru
Osechkina Natal’ya Sergeevna
107014, Moscow
Russian FederationG. V. Nazarov
Scientific Center «Signal»
Email: fake@neicon.ru
Nazarov Georgiy Valer’evich
107014, Moscow
Russian FederationM. B. Ivanov
Institute of Toxicology, Federal Medical Biological Agency
Email: m.b.ivanov@toxicology.ru
Ivanov Maksim Borisovich
192019, Saint Petersburg
Russian FederationE. G. Batotsyrenova
Institute of Toxicology, Federal Medical Biological Agency
Email: fake@neicon.ru
Batotsyrenova Ekaterina Gennad’evna
192019, Saint Petersburg
Russian FederationV. A. Kashuro
Institute of Toxicology, Federal Medical Biological Agency
Email: fake@neicon.ru
Kashuro Vadim Anatol’evich
192019, Saint Petersburg
Russian FederationN. V. Lapina
Institute of Toxicology, Federal Medical Biological Agency
Email: fake@neicon.ru
Lapina Natal’ya Vadimovna
192019, Saint Petersburg
Russian FederationO. V. Varlamova
Scientific Center «Signal»
Email: fake@neicon.ru
Varlamova Olga Vyacheslavovna
107014, Moscow
Russian FederationI. S. Kravtsov
Scientific Center «Signal»
Email: fake@neicon.ru
Kravtsov Ivan Sergeevich
107014, Moscow
Russian FederationA. V. Babkin
Scientific Center «Signal»
Email: fake@neicon.ru
Babkin Aleksandr Vladimirovich
107014, Moscow
Russian FederationA. S. Kraeva
Scientific Center «Signal»
Email: fake@neicon.ru
Kraeva Anna Sergeevna
107014, Moscow
Russian FederationA. S. Melekhova
Institute of Toxicology, Federal Medical Biological Agency
Email: fake@neicon.ru
Melehova Aleksandra Sergeevna
192019, Saint Petersburg
Russian FederationK. O. Voitsekhovich
Institute of Toxicology, Federal Medical Biological Agency
Email: fake@neicon.ru
Voicehovih Karina Olegovna
192019, Saint Petersburg
Russian FederationD. S. Lisitskii
Institute of Toxicology, Federal Medical Biological Agency
Email: fake@neicon.ru
Lisitskii Dmitrii Sergeevich
192019, Saint Petersburg
Russian FederationReferences
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