Email this article ACUTE TOXICITY OF THE MINERAL COMPLEX BASED ON NANOPOWDERS OF IRON, COPPER AND ZINC AFTER A SINGLE INTRAPERITONEAL INJECTION
- Authors: Andreeva E.Y.1, Rodionova T.N.1, Gorbunov D.V.2, Marinicheva M.P.1
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Affiliations:
- N.I. Vavilov Saratov State Agrarian University.
- Institute of Toxicology of the Federal Medical and Biological Agency.
- Issue: No 6 (2018)
- Pages: 22-24
- Section: Articles
- Published: 28.12.2018
- URL: https://rjsvd.com/0869-7922/article/view/641133
- DOI: https://doi.org/10.36946/0869-7922-2018-6-22-24
- ID: 641133
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Abstract
An injection form of the mineral complex consisting of a mixture of iron, zinc and copper nanopowders has been proposed. According to the results of studies the injection form of the drug based on metal nanopowders belongs to the V-VI class of practically non-toxic, relatively harmless drugs by Hodge and to the 5th class of toxicity in accordance with GOST 32644-2014.
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About the authors
E. Yu. Andreeva
N.I. Vavilov Saratov State Agrarian University.
Author for correspondence.
Email: fake@neicon.ru
410012, Saratov. Russian Federation
T. N. Rodionova
N.I. Vavilov Saratov State Agrarian University.
Email: fake@neicon.ru
410012, Saratov. Russian Federation
D. V. Gorbunov
Institute of Toxicology of the Federal Medical and Biological Agency.
Email: fake@neicon.ru
192019, Saint-Petersburg. Russian Federation
M. P. Marinicheva
N.I. Vavilov Saratov State Agrarian University.
Email: fake@neicon.ru
410012, Saratov. Russian Federation
References
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- Alyautdin R.N., Romanov B.K. Recommendations for the evaluation of the safety of drugs containing nanoparticles. Safety and risk of pharmacotherapy. 2015; 5: 10-21. (in Russian)
- Guidelines for conducting preclinical studies of drugs. Part one. Edited by Mironov A.N. - M .: Grief and K, 20- 944 p. (in Russian)
- GOST 32644-2014 Test methods for the effects of chemical products on the human body. Acute oral toxicity - method for determining the class of acute toxicity, 2015. (in Russian)
- Reznichenko L.S., Dybkova S.N., Doroshenko A.M., Chekmani I.S., Ulberg Z.R. Synthesis of iron nanoparticles and characterization of their biosafety. Bulletin of problems of biology and medicine. 2014; 3 (2): 319-323. (in Russian)
- Prozorovsky V.B. Statistical processing of pharmacological research results. Psychopharmacology and biological narcology. 207 (3): 2090-2120. (in Russian
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