EFFECT OF CARBON TETRACHLORIDE ON THE LIPID COMPOSITION OF RAT’S BLOOD AND ITS CORRECTION BY NATURAL HERBAL POLYPHENOLS

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Abstract

The possibility of blood lipid metabolism recovery in rats after intoxication with carbon tetrachloride using Kalifen® extract from viburnum and the comparison preparation Legalon® has been shown. The experiments were conducted on male white rats of the Wistar line in standard vivarium conditions. Animals were divided into 5 groups: 1st group - control; 2nd group - introduction of carbon tetrachloride for 4 days; 3rd - introduction of carbon tetrachloride for 4 days followed by cancellation within 7 days; 4th group - introduction of carbon tetrachloride for 4 days followed by introduction of Kalifen® for 7 days; 5th - introduction of carbon tetrachloride for 4 days followed by introduction of Legalon® for 7 days.
It has been found that intoxication with carbon tetrachloride was accompanied by the development of severe hypercholesterolemia, as well as the increase in the content of the total fraction of lipoproteins of very low density with reducing the concentration of high density lipoproteins in the serum. There were a decrease in the main structural phospholipids and metabolically active fractions, an increase in the number of triacylglycerols, free fatty acids, and lysophospholipids.
During the cancellation of carbon tetrachloride within 7 days lipid metabolism indicators did not recover, indicating that free-radical reactions occur even in the absence of the toxicant. The introduction of Kalifen® and Legalon® in animals under the conditions of the withdrawal of the toxicant contributed to the recovery of the studied parameters to control values, but the most pronounced effect has been manifested using Kalifen®.

About the authors

E. S. Drugova

V.I. Il’ichev Pacific Oceanological Institute FEBRAS, 690041, Vladivostok

Author for correspondence.
Email: dryg-2005.84@mail.ru
Другова Елена Сергеевна (Drugova Elena Sergeevna), кандидат биологических наук, научный сотрудник лаборатории биохимии Russian Federation

N. F. Kushnerova

V.I. Il’ichev Pacific Oceanological Institute FEBRAS, 690041, Vladivostok

Email: nkushnerova@poi.dvo.ru
Кушнерова Наталья Федоровна (Kushnerova Natalya Fedorovna), доктор биологических наук, профессор, заведующая лабораторией биохимии Russian Federation

S. E. Fomenko

V.I. Il’ichev Pacific Oceanological Institute FEBRAS, 690041, Vladivostok

Email: sfomenko@poi.dvo.ru
Фоменко Светлана Евгеньевна (Fomenko Svetlana Evgenievna), кандидат биологических наук, ведущий научный сотрудник лаборатории биохимии Russian Federation

V. G. Sprygin

V.I. Il’ichev Pacific Oceanological Institute FEBRAS, 690041, Vladivostok

Email: vsprygin@poi.dvo.ru
Спрыгин Владимир Геннадьевич (Sprygin Vladimir Gennadievich), кандидат биологических наук, ведущий научный сотрудник лаборатории биохимии Russian Federation

L. N. Lesnikova

V.I. Il’ichev Pacific Oceanological Institute FEBRAS, 690041, Vladivostok

Email: lesnikova@poi.dvo.ru
Лесникова Лариса Николаевна (Lesnikova Larisa Nikolaevna), кандидат биологических наук, научный сотрудник лаборатории биохимии Russian Federation

V. Yu. Merzlyakov

V.I. Il’ichev Pacific Oceanological Institute FEBRAS, 690041, Vladivostok

Email: vum77@mail.ru
Мерзляков Валерий Юрьевич (Merzlyakov Valery Yurievich), научный сотрудник лаборатории биохимии Russian Federation

T. V. Momot

Far Eastern Federal University, 690000, Vladivostok

Email: momot@dvfu.ru
Момот Татьяна Викторовна (Momot Tatiana Viktorovna), кандидат медицинских наук, директор департамента биохимии и биофизики Школы биомедицины Russian Federation

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Copyright (c) 2019 Drugova E.S., Kushnerova N.F., Fomenko S.E., Sprygin V.G., Lesnikova L.N., Merzlyakov V.Y., Momot T.V.


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