Email this article ASSESSMENT OF TOXICITY OF GERMANIUM COORDINATION COMPOUNDS
- Authors: Kadomtsevа A.V.1, Zhdanovich I.V.1, Piskunovа M.S.1, Lineva A.N.1, Novikova A.N.1, Loginov P.A.1
-
Affiliations:
- Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950, Nizhny Novgorod
- Issue: No 2 (2019)
- Pages: 16-21
- Section: Articles
- Published: 28.04.2019
- URL: https://rjsvd.com/0869-7922/article/view/641127
- DOI: https://doi.org/10.36946/0869-7922-2019-2-16-21
- ID: 641127
Cite item
Full Text
Abstract
The synthesis of biologically active coordination compounds and the design on their basis of effective pharmacological preparations is currently the promising area. This paper presents the results of the toxicological studies on digermanium and its complex derivatives. It should be noted that the positive medical properties of organometallic compounds of germanium are confirmed by numerous studies, therefore, the development of the methods of synthesis, as well as investigations of physicochemical and pharmacological properties of these compounds are at the center of attention.
About the authors
A. V. Kadomtsevа
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950, Nizhny Novgorod
Author for correspondence.
Email: rector@pimunn.ru
Кадомцева Алёна Викторовна (Kadomtsevа Alena Viktorovna), кандидат химических наук, старший преподаватель кафедры общей химии Russian Federation
I. V. Zhdanovich
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950, Nizhny Novgorod
Email: rector@pimunn.ru
Жданович Ирина Владимировна (Zhdanovich Irina Vladimirovna), доцент, кандидат химических наук, доцент кафедры общей химии Russian Federation
M. S. Piskunovа
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950, Nizhny Novgorod
Email: rector@pimunn.ru
Пискунова Марина Сергеевна (Piskunovа Marina Sergeevna), доцент, кандидат химических наук., доцент кафедры общей химии Russian Federation
A. N. Lineva
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950, Nizhny Novgorod
Email: rector@pimunn.ru
Линева Альбина Николаевна (Lineva Al’bina Nikolaevna), доцент, кандидат химических наук, доцент кафедры общей химии Russian Federation
A. N. Novikova
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950, Nizhny Novgorod
Email: rector@pimunn.ru
Новикова Антонина Николаевна (Novikova Antonina Nikolaevna), кандидат химических наук, старший преподаватель кафедры общая химия Russian Federation
P. A. Loginov
Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, 603950, Nizhny Novgorod
Email: rector@pimunn.ru
Логинов Петр Александрович (Loginov Petr Alexandrovich), младший научный сотрудник центра доклинических исследований ЦНИЛ Russian Federation
References
- Kadomtseva A.V. Fundamental aspects of the development of anticancer drugs with directed action. All-Russian youth forum with international participation “Week of science-2017”, Stavropol, 2017, 491-492 (in Russian).
- Kucherenko M.Ye., Babenyuk Yu.D., Vasil’ev O.M. Biokhimiya, Kiev, 2002, 480 (in Russian).
- Seifullina I.I., Martsinko E.E. Coordination compounds of germanium (IV) with anions of citric, tartaric and xylar acids. 2015, 148 (in Russian).
- Pyatnitsky I.V. Complex compounds of metals with oxy-acids. 1963, 32 (1), 93-119 (in Russian).
- Porlanova R., Lajunen L.H.J. Critical evaluation of stability constants for α-hydroxycarboxylic acid complexes with protons and metal ions and the accompanying enthalpy changes. Part II. Aliphatic 2-hydroxycarboxylic acids. Pure Appl. Chem. 2003, 75(4), 495-540.
- Nazarenko V.A. Analytical chemistry of germanium, Science, 1973, 262 p (in Russian).
- Yushkov V.V., Vakhrin A.S. etc. Materials to substantiate of the MAC of germanium tetrafluoride in the air of the working area. Angarsk, 2003, 22 p (in Russian).
- Kadomtseva A.V., Ob’edkov A.M., Semenov N.M., Kaverin B.S., Gusev S.A. Preparation and study of influence of the catalyst based on ash microspheres coated with pyrolytic tungsten on the process of obtaining metallic germanium. Journal of Applied Chemistry. 2016, 89 (11), 1797-1805 (doi: 10.1134/S1070427216110100).
- Kadomtseva A.V., Ob’edkov A.M., Semenov N.M., Kaverin B.S., Kremlev K.V., Gusev S.A., Yunin P.A. Comparative analysis of catalysts for obtaining germanium by hydrogen reduction of the tetrachloride germanium. Inorganic Materials. 2018, 54 (10), 971-976 (doi: 10.1134/S0020168518100084).
- Kadomtseva A.V., Ob’edkov A.M. Reduction of germanium tetrachloride in the presence of a catalyst based on modified nickel chloride (II). Inorganic Materials. 2017, 53 (12), 1312-1318 (doi: 10.1134/S0020168517120056).
- Krasnikova O.V., Gordetsov A.S., Kontorshchikova K.N., Krylov V.N., Sazanov A.I. Changes in the IR spectra of biological tissues of tumor-bearing animals under the joint introduction of doxorubicin and ozone. Modern technologies in medicine. 2011, 3, 83-87 (in Russian).
- Krasnikova O.V., Gordetsov A.S., Krylov V.N. Changes in the IR spectra of blood plasma of tumor-bearing animals under the introduction of biologically active additives. Modern technologies in medicine. 2011, 4, 18-21 (in Russian).
- Krasnikova O.V., Gordetsov A.S., Kontorshchikova K.N., Krylov V.N., Sazanov A.I. Changes in the IR spectra of biological tissues of tumor-bearing animals under the joint introduction of doxorubicin and ozone. Bulletin of N.I. Lobachevsky Nizhny Novgorod State University. 2011, 5 (1), 105-109 (in Russian).
- Zhdanovich I.V., Lineva A.N., Latyaeva V.N., Novotortsev V.M., Eremenko I.L, Struchkov Yu.T. Molecular structure and magnetic properties of heteronuclear complex CP2VTE2GE2(C6F5)Russian journal of inorganic chemistry. 1999, 44 (7), 1056-1059 (in Russian).
- Eremenko I.L., Struchkov Yu.T., Zhdanovich I.V., Pankratov L.V., Bochkarev M.N., Latyaeva V.N., Lineva A.N. The molecular structure of the complex CP2VSGE(C6F5)2SGE(C6F5) Russian Journal of Inorganic Chemistry. 1996, 41 (6), 1028-1031 (in Russian).
Supplementary files
