MECHANISMS OF INCREASED RESISTANCE TO INFECTION IN THE EARLY PHASE OF SEPSIS IN MICE AFTER ACUTE INTOXICATION WITH ORGANOPHOSPHORUS COMPOUNDS

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Abstract

It was established in experiments on random-bred albino mice that the reduction of mortality of mice from sepsis and decrease of pro-inflammatory cytokines (TNF- , IL-1 , IL-6 ) concentrations in blood after acute intoxication with organophosphorus compounds (OPCs) is due to the implementation of the cholinergic antiinflammatory pathway: activation of muscarinic acetylcholine receptors m1 and 7n-acetylcholine receptors of the monocyte macrophage system. The anti-inflammatory effect after acute intoxication with OPCs is also associated with excitation of the sympathetic nervous system, 2 adrenergic receptors on T-lymphocytes, macrophages and monocytes and the subsequent reduction of pro-inflammatory cytokines in blood.

About the authors

P. F. Zabrodskii

Saratov Branch of «Samara Medical Institute «REAVIZ»

Author for correspondence.
Email: noemail@neicon.ru
Russian Federation

V. V. Maslyakov

Saratov Branch of «Samara Medical Institute «REAVIZ»

Email: noemail@neicon.ru
Russian Federation

M. S. Gromov

Saratov Branch of «Samara Medical Institute «REAVIZ»

Email: noemail@neicon.ru
Russian Federation

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Copyright (c) 2016 Zabrodskii P.F., Maslyakov V.V., Gromov M.S.


СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
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