Ti-Mg-Catalyzed Carbozincation of N-Benzyl-N-(but-3-en-1-yl)Hept-2-Yn-1-Amine with Et2Zn

Мұқаба

Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Тек жазылушылар үшін

Аннотация

It has been shown for the first time that the Ti-Mg-catalyzed carbozincation reaction of N-benzyl-N-(but-3-en-1-yl)hept-2-yn-1-amine with Et2Zn is accompanied by regio- and stereoselective formation of (Z)-1-benzyl-4-methyl-3-pentylidenepiperidine. The effect of the nature of the solvent on the Ti-Mg-catalyzed heterocyclization of N-benzyl-N-(but-3-en-1-yl)hept-2-yn-1-amine was studied. A mechanism is proposed for the studied reaction of carbozincation of N-homoallyl-substituted propargylamine with Et2Zn in the presence of catalytic amounts of Ti(O-iPr)4 and EtMgBr.

Толық мәтін

Рұқсат жабық

Авторлар туралы

A. Gabdullin

Institute of Petrochemistry and Catalysis of the Ufa Federal Research Center of the Russian Academy of Sciences

Email: kadikritan@gmail.com
ORCID iD: 0000-0001-5204-7394
Ресей, Ufa

R. Kadikova

Institute of Petrochemistry and Catalysis of the Ufa Federal Research Center of the Russian Academy of Sciences

Хат алмасуға жауапты Автор.
Email: kadikritan@gmail.com
ORCID iD: 0000-0002-4636-1739
Ресей, Ufa

I. Ramazanov

Institute of Petrochemistry and Catalysis of the Ufa Federal Research Center of the Russian Academy of Sciences

Email: kadikritan@gmail.com
ORCID iD: 0000-0002-3846-6581
Ресей, Ufa

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Қосымша файлдар

Қосымша файлдар
Әрекет
1. JATS XML
Жүктеу
2. Scheme 1. Ti-Mg-Catalysed carbocinylation reaction of N-allyl-substituted 2-alkynylamines

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3. Scheme 2. Ti-Mg-Catalysed carbocinylation reaction of N-benzyl-N-(but-3-en-1-yl)hept-2-in-1-amine

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4. Scheme 3. Putative mechanism of catalytic 2-cincoethylzincination of N-homoallyl-substituted 2-alkynylamines

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5. Scheme 4. Ti-Mg-Catalysed carbocinylation reaction of N-benzyl-N-(but-3-en-1-yl)hept-2-in-1-amine in the medium of different solvents

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6. Scheme 5. Effect of solvent nature on the Ti-Mg-catalysed reaction of N-(but-2-in-1-yl)-N-methylbut-3-en-1-amine with Et2Zn

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7. Scheme 6

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