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Synthesis, structure and reactions of substituted 2-aminotetrahydrochynoline-3-carbonitriles
- Authors: Nikulin A.V.1, Vasilkova N.O.1, Krivenko A.P.1
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Affiliations:
- Saratov National Research State named after N.G. Chernyshevsky (SSU)
- Issue: Vol 60, No 6 (2024)
- Pages: 69-77
- Section: Articles
- URL: https://rjsvd.com/0514-7492/article/view/676675
- DOI: https://doi.org/10.31857/S0514749224060064
- EDN: https://elibrary.ru/QZTAGE
- ID: 676675
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Abstract
A series of substituted 2-aminotetrahydroquinolinecarbonitriles was obtained by three-component condensation of diaryl(hetaryl)methylidenecyclohexanones, malononitrile and ammonium acetate. Factors influencing the selectivity of reactions and the route of product formation have been identified. The interaction of aminoquinoline carbonitriles with acetic anhydride under acid catalysis conditions led to the formation of substituted hexahydropyrimido[4,5-b]quinolinones. The structure of the compounds was established using IR, 1H, 13C NMR spectra and two-dimensional correlations HSQC spectroscopy.
About the authors
A. V. Nikulin
Saratov National Research State named after N.G. Chernyshevsky (SSU)
Email: vasilkovano@mail.ru
ORCID iD: 0000-0002-2123-4960
Institute of Chemistry
Russian Federation, ul. Astrakhanskaya, 83/1, Saratov, 410012N. O. Vasilkova
Saratov National Research State named after N.G. Chernyshevsky (SSU)
Author for correspondence.
Email: vasilkovano@mail.ru
ORCID iD: 0000-0001-9437-0704
Institute of Chemistry
Russian Federation, ul. Astrakhanskaya, 83/1, Saratov, 410012A. P. Krivenko
Saratov National Research State named after N.G. Chernyshevsky (SSU)
Email: vasilkovano@mail.ru
ORCID iD: 0000-0003-3277-4556
Institute of Chemistry
Russian Federation, ul. Astrakhanskaya, 83/1, Saratov, 410012References
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