Серотонин и надпочечники: регуляция функций, регуляция развития

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Аннотация

Серотонин является не только нейротрансмиттером, но и важным гуморальным регулятором разнообразных физиологических процессов за пределами центральной нервной системы. В последнее десятилетие складывается концепция существования локальных серотонинергических систем в периферических органах, где серотонин реализует свое воздействие через аутокринно-паракринные механизмы. Такие локальные системы уже описаны в поджелудочной железе, тимусе, молочной железе, красном костном мозге. Мы считаем, что подобная локальная серотонинергическая система характерна и для надпочечников. Эти парные органы являются ключевым компонентом эндокринной системы млекопитающих, обеспечивающим комплексную физиологическую реакцию на стресс. Надпочечники состоят из двух неродственных по происхождению и функциям отделов – коры и медуллы, при этом серотонин играет важную роль в регуляции секреции гормонов в обеих этих структурах. Цель данного обзора – анализ структуры локальной серотонинергической системы в надпочечнике, а также ее роли как в регуляции функций надпочечников у взрослых животных, так и в их формировании в эмбриогенезе. Обобщение имеющихся данных позволяет говорить о том, что наличие локальной серотонинергической системы делает орган восприимчивым к колебаниям уровня циркулирующего в крови серотонина на всех этапах онтогенеза. Таким образом, локальная чувствительность к серотонину обеспечивает возможность системной гуморальной координации формирования и функционирования как надпочечников, так и других периферических органов. В этом аспекте становится понятна важность локальных серотонинергических систем для медицины и биологии развития.

Об авторах

В. И. Мельникова

Институт биологии развития им. Н.К. Кольцова РАН

Автор, ответственный за переписку.
Email: v_melnikova@mail.ru
Россия, 119334, Москва, ул. Вавилова, 26

Н. С. Бондаренко

Институт биологии развития им. Н.К. Кольцова РАН

Email: v_melnikova@mail.ru
Россия, 119334, Москва, ул. Вавилова, 26

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