Development of N.K. Koltsov Idea about Genetic Organization of Interbands in Drosophila melanogaster Polytene Chromosomes

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Resumo

Here for the first time, the organization of promoters of developmental gene promoters and promoter of genes necessary for general cellular functions—the “houskeeping” of the cell in the complete genome of Drosophila melanogaster were studied. Using bioinformatic methods, it has been shown that the genes whose promoters are located in the interbands of polytene chromosomes are enriched in functions associated with general cellular processes, while the rest of the genes (about half of the Drosophila genome) are associated with highly specialized processes occurring during development. In the promoter zone of the housekeeping genes, four specific motifs were found that can be present in different genes individually or in various combinations. A significant part of interband promoters do not contain identified motifs. The analysis carried out using Gene Ontology showed that certain groups of interband genes containing one motif in promoters or their combinations are characterized by the performance of certain functions.

Sobre autores

I. Zhimulev

Institute of Molecular and Cellular Biology SB RAS

Autor responsável pela correspondência
Email: zhimulev@mcb.nsc.ru
Russia, 630090, Novosibirsk, prosp. ak. Lavrentieva 8/2

T. Vatolina

Institute of Molecular and Cellular Biology SB RAS

Email: zhimulev@mcb.nsc.ru
Russia, 630090, Novosibirsk, prosp. ak. Lavrentieva 8/2

V. Levitsky

Institute of Cytology and Genetics SB RAS

Email: zhimulev@mcb.nsc.ru
Russia, 630090, Novosibirsk, prosp. ak. Lavrentieva 10

T. Kolesnikova

Institute of Molecular and Cellular Biology SB RAS

Email: zhimulev@mcb.nsc.ru
Russia, 630090, Novosibirsk, prosp. ak. Lavrentieva 8/2

A. Tsukanov

Institute of Cytology and Genetics SB RAS

Email: zhimulev@mcb.nsc.ru
Russia, 630090, Novosibirsk, prosp. ak. Lavrentieva 10

Bibliografia

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Declaração de direitos autorais © И.Ф. Жимулев, Т.Ю. Ватолина, В.Г. Левицкий, Т.Д. Колесникова, А.В. Цуканов, 2023