Study of the Reduction of Cobalt(III) Complexes by In Situ NMR Spectroscopy

I. A. Nikovskii; Никовский И. А.; D. A. Babakina; Бабакина Д. А.; G. L. Denisov; Денисов Г. Л.; Yu. V. Nelyubina; Нелюбина Ю. В.; E. A. Khakina; Хакина Е. А.

doi:10.31857/S0132344X22700037

Study of the Reduction of Cobalt(III) Complexes by In Situ NMR Spectroscopy

Authors: Nikovskii I.A.¹, Babakina D.A.², Denisov G.L.¹^,3, Nelyubina Y.V.¹^,3, Khakina E.A.¹^,3
Affiliations:
1. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia
2. Mendeleev University of Chemical Technology of Russia, Moscow, Russia
3. Bauman State Technical University (National Research University), Moscow, Russia
Issue: Vol 49, No 1 (2023)
Pages: 27-35
Section: Articles
URL: https://rjsvd.com/0132-344X/article/view/667536
DOI: https://doi.org/10.31857/S0132344X22700037
EDN: https://elibrary.ru/ERVRRS
ID: 667536

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Abstract

An approach for monitoring the redox activation of drug delivery in cobalt(III) complexes by in situ NMR spectroscopy is proposed. The reduction of the heteroleptic cobalt(III) complexes containing the 6,7-dihydroxycoumarin molecule applied as a model drug is studied using the proposed approach. The replacement of the bipyridine ligand in the cobalt(III) complex by phenanthroline considerably increases the redox-activated release rate of the drug.

Keywords

in situ NMR spectroscopy, dihydroxycoumarin, cobalt complexes, redox-activated drug delivery

About the authors

I. A. Nikovskii

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia

Email: khakina90@ineos.ac.ru
Россия, Москва

D. A. Babakina

Mendeleev University of Chemical Technology of Russia, Moscow, Russia

Email: khakina90@ineos.ac.ru
Россия, Москва

G. L. Denisov

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia; Bauman State Technical University (National Research University), Moscow, Russia

Email: khakina90@ineos.ac.ru
Россия, Москва; Россия, Москва

Yu. V. Nelyubina

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia; Bauman State Technical University (National Research University), Moscow, Russia

Email: khakina90@ineos.ac.ru
Россия, Москва; Россия, Москва

E. A. Khakina

Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, Russia; Bauman State Technical University (National Research University), Moscow, Russia

Author for correspondence.
Email: khakina90@ineos.ac.ru
Россия, Москва; Россия, Москва

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