Use of ytterbium porphyrins complexes in cancer theranostics

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Abstract

The principles of new cancer theranostics methods based on nanosized Yb-porphyrins complexes have been developed. The obtained data indicate the promise of using synthesized nanoparticles based on Yb-porphyrins complexes for the development of sensitive luminescent diagnostics and theranostics methods for tumors of visually and endoscopically accessible localization. It is shown that laser photothermolysis at a wavelength of 750...800 nm in combination with near-IR luminescent diagnostics (in the spectral range of 900...1100 nm) is a pioneering development in the medical biophotonics. It is predicted that the synthesized structure of the Lexan-polymer matrix + Yb-porphyrin complex + FeOx can be in demand for the purposes of neoplasms magneto-luminescent theranostics. It has been established that tumors luminescent diagnostics in combination with photodynamic therapy in the porphyrin absorption band (wavelength 635 nm at an optical exposure dose of ~300 J/cm2) using the Fluroscan-type pharmaceutical composition can be used for malignant neoplasms of the skin and mucous membranes.

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About the authors

I. P. Shilov

Fryazino Branch Kotelnikov Institute of Radioengineering and Electronics of RAS

Author for correspondence.
Email: laserlab@ms.ire.rssi.ru
Russian Federation, Vvedenskii Squar., 1, Fryazino, Moscow Region, 141190

V. D. Rumyantseva

Fryazino Branch Kotelnikov Institute of Radioengineering and Electronics of RAS; MIREA – Russian Technological University

Email: laserlab@ms.ire.rssi.ru
Russian Federation, Vvedenskii Squar., 1, Fryazino, Moscow Region, 141190; Vernadsky Prosp., 78, Moscow, 119454

A. S. Gorshkova

Fryazino Branch Kotelnikov Institute of Radioengineering and Electronics of RAS

Email: laserlab@ms.ire.rssi.ru
Russian Federation, Vvedenskii Squar., 1, Fryazino, Moscow Region, 141190

A. V. Ivanov

National Medical Research Center of Oncology named after N. N. Blokhin

Email: laserlab@ms.ire.rssi.ru
Russian Federation, Kashirskoe Shos., 23, Moscow, 115522

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Supplementary files

Supplementary Files
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2. Fig. 1. Scheme of synthesis of composite multifunctional nanoparticles based on gold-silver nanocages coated with silicon dioxide and functionalized with ICP.

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3. Fig. 2. IR luminescence spectra of the nanocomposite (1) and free aqueous solution of ICP (2).

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4. Fig. 3. Biodistribution of the nanocomposite and free aqueous solution of ICP in the organs of mice with grafted Ehrlich carcinoma.

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5. Fig. 4. Structural diagram of the nanocomposite LPM + ICP + FeOx (ICP – Yb-PP).

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6. Fig. 5. Distribution of composite nanoparticles by size (at a concentration of LPM in the reaction mixture of ~ 100 μg/l).

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7. Fig. 6. Emission spectra in the near IR region of the spectrum (λexc ~ 532 nm) of nanocomposites of LPM + Yb-TME GP without a MNP core (1) and with a Fe3O4 core with an average size d ~ 20 (2) and ~ 30 (3) nm.

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8. Fig. 7. Histogram of the distribution of luminescence intensity in various organs and tissues of a mouse after intravenous administration of the drug (ex vivo mode, dose 1 mg/kg body weight, accumulation time 12 hours).

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9. Fig. 8. Electronic absorption spectra: 1 – Yb-DMDP + ascorbic acid, 2 – Yb-DMDP, 3 – metal-free DMDP.

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10. Fig. 9. Average thermogram typical for the 2nd group of laboratory mice (exposure dose 300 J/cm2).

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11. Fig. 10. Background thermogram recording of Lewis lung epidermoid carcinoma, exposed to radiation of 500 mW/cm2; 200 s, exposure dose of 100 J/cm2.

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