HIGH-CAPACITY CALCIUM CARBONATE PARTICLES AS PH-SENSITIVE CONTAINERS FOR DOXORUBICIN

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Abstract

Nanostructured submicron calcium carbonate particles with sizes of 500 ± 90 and 172 ± 75 nm have been synthesized by mass crystallization in aqueous solutions with addition of glycerol, as well as a mixture of polyethylene glycol, polysorbate, and a cellular medium. CaCO3 : Si : Fe nanoparticles 65 ± 15 nm in size have been obtained by template synthesis in pores of silica particles. The crystal structure and polymorphism of these particles are studied, and the influence of the size and structure of particles on the efficiency of their loading with a chemotherapy agent , as well as its release under model conditions at different рН, is determined.

About the authors

T. N. Pallaeva

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, Moscow, 119333 Russia

Email: trushina.d@mail.ru
Россия, Москва

A. V. Mikheev

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, Moscow, 119333 Russia

Email: trushina.d@mail.ru
Россия, Москва

D. N. Khmelenin

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, Moscow, 119333 Russia

Email: trushina.d@mail.ru
Россия, Москва

D. A. Eurov

Ioffe Institute, Russian Academy of Sciences, St. Petersburg, 194021 Russia

Email: trushina.d@mail.ru
Россия, Санкт-Петербург

D. A. Kurdyukov

Ioffe Institute, Russian Academy of Sciences, St. Petersburg, 194021 Russia

Email: trushina.d@mail.ru
Россия, Санкт-Петербург

V. K. Popova

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Email: trushina.d@mail.ru
Россия, Новосибирск

E. V. Dmitrienko

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

Email: trushina.d@mail.ru
Россия, Новосибирск

D. B. Trushina

Shubnikov Institute of Crystallography, Federal Scientific Research Centre “Crystallography and Photonics,” Russian Academy of Sciences, Moscow, 119333 Russia; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Author for correspondence.
Email: trushina.d@mail.ru
Россия, Москва; Россия, Москва

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