Effect of Pulsed Electron Beam Treatment on the Release Profile of Chloramphenicol from Polylactic Acid–Based Polymeric Scaffolds

A. A. Volokhova; Волохова А. А.; D. V. Ponomarev; Пономарев Д. В.; I. A. Kurzina; Курзина И. А.; S. I. Tverdokhlebov; Твердохлебов С. И.

doi:10.31857/S0023119323030178

Effect of Pulsed Electron Beam Treatment on the Release Profile of Chloramphenicol from Polylactic Acid–Based Polymeric Scaffolds

Authors: Volokhova A.A.¹^,2, Ponomarev D.V.³, Kurzina I.A.¹, Tverdokhlebov S.I.²
Affiliations:
1. National Research Tomsk State University
2. Weinberg Research Center, National Research Tomsk Polytechnic University
3. Research and Production Laboratory of Pulse-Beam, Electric Discharge, and Plasma Technologies, National Research Tomsk Polytechnic University
Issue: Vol 57, No 3 (2023)
Pages: 201-205
Section: RADIATION CHEMISTRY
URL: https://rjsvd.com/0023-1193/article/view/661505
DOI: https://doi.org/10.31857/S0023119323030178
EDN: https://elibrary.ru/KIPECN
ID: 661505

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Abstract

The paper presents the results of testing the properties of antibacterial nonwoven fibrous materials based on polylactic acid with incorporated chloramphenicol. It has been shown that exposure to a pulsed electron beam increased the rate of release of chloramphenicol into a phosphate-buffered saline medium. In this case, the amount of the substance released from treated samples was reliably greater than that with untreated samples during the five days of the experiment

Keywords

pulsed electron beam, biodegradable polymers, polymer modification

About the authors

A. A. Volokhova

National Research Tomsk State University; Weinberg Research Center, National Research Tomsk Polytechnic University

Email: rapollinariya@gmail.com
Tomsk, 634050 Russia; Tomsk, 634050 Russia

D. V. Ponomarev

Research and Production Laboratory of Pulse-Beam, Electric Discharge, and Plasma Technologies, National Research Tomsk Polytechnic University

Email: rapollinariya@gmail.com
Tomsk, 634050 Russia

I. A. Kurzina

National Research Tomsk State University

Email: rapollinariya@gmail.com
Tomsk, 634050 Russia

S. I. Tverdokhlebov

Weinberg Research Center, National Research Tomsk Polytechnic University

Author for correspondence.
Email: rapollinariya@gmail.com
Tomsk, 634050 Russia

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