Effect of Copper Ions on Quercetin Reactivity in Free Radical Reactions and Radioprotective Activity

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Abstract

Steady state radiolysis showed a decrease in the reactivity of quercetin in free radical reactions with the 1-hydroxyethyl radical and the superoxide radical anion as a result of the formation of a complex with a copper ion. The negative effect of copper ions can be reduced via destroying the resulting complex by introducing chelating compounds, such as tartaric acid and EDTA. The nature of the change in reactivity corresponded to the change in the radioprotective activity of quercetin in relation to yeast cells.

About the authors

A. G. Lysenko

Mendeleev University of Chemical Technology

Email: fenin.a.a@muctr.ru
Moscow, 125480 Russia

A. A. Fenin

Mendeleev University of Chemical Technology

Author for correspondence.
Email: fenin.a.a@muctr.ru
Moscow, 125480 Russia

References

  1. Кудряшов Ю. Б. Радиационная биофизика (ионизирующие излучения) / Под ред. В.К. Мазурика, М.Ф. Ломанова. М.: ФИЗМАТЛИТ, 2004. 448 с.
  2. Zeng Y., Song J., Zhang M., Wang H., Zhang Y., Suo H.. // Antioxidants (Basel). 2020. V. 9(8). P. 732. PMID; PMCID: PMC7465758.https://doi.org/10.3390/antiox908073232796543
  3. Raman S.T., Ganeshan A.K., Chen C., Jin C., Li S.H., Chen H.J., Gui Z. // Pharmacogn Mag. 2016. V. 12(46). P. 128–33. PMID; PMCID: PMC4809167.https://doi.org/10.4103/0973-1296.17791027076749
  4. Terao J. // The J. Medical Investigation: JMI. 1999. V. 46(3–4). P. 159–168. PMID: 10687310
  5. Procházková D., Boušová I., Wilhelmová N. // Fitoterapia. 2011. T. 82. № 4. C. 513.
  6. Lekka C.E. et al. // The J. Physical Chemistry B. 2009. T. 113. № 18. C. 6478.
  7. Костюк В.А. Биорадикалы и биоантиоксиданты / В.А. Костюк, А.И. Потапович. Минск. 2004. С. 10–16; С. 82–98.
  8. Jomová K., Hudecova L., Lauro P., Simunkova M., Alwasel S.H., Alhazza I.M., Valko M. // Molecules. 2019. V. 24(23). P. 4335. PMID; PMCID: PMC6930463.https://doi.org/10.3390/molecules2423433531783535
  9. Žuvela P., David J., Yang X., Huang D., Wong M.W. // Int. J. Mol. Sci. 2019. V. 20(9). P. 2328. PMID; PMCID: PMC6539043.https://doi.org/10.3390/ijms2009232831083440
  10. Simunkova M., Barbierikova Z., Jomova K., Hudecova L., Lauro P., Alwasel S.H., Alhazza I., Rhodes C.J., Valko M. // Int. J. Mol. Sci. 2021. V. 22(4). P. 1619. PMID; PM-CID: PMC7915082.https://doi.org/10.3390/ijms2204161933562744
  11. Суворова А.А., Фенин А.А. // Радиационная биология. Радиоэкология. 2010. Т. 50. № 2. С. 180.

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