Rheological Properties of Gel Systems Based on Gamma-Irradiated Lightly Crosslinked Polyacrylic Acid

V. A. Abramov; Абрамов В. А.; A. R. Gataullin; Гатауллин А. Р.; S. A. Bogdanova; Богданова С. А.; S. V. Demidov; Демидов С. В.; R. A. Kemalov; Кемалов Р. А.; S. R. Allayarov; Аллаяров С. Р.

doi:10.31857/S0023119323060013

Rheological Properties of Gel Systems Based on Gamma-Irradiated Lightly Crosslinked Polyacrylic Acid

Authors: Abramov V.A.¹, Gataullin A.R.¹, Bogdanova S.A.¹, Demidov S.V.², Kemalov R.A.³, Allayarov S.R.²
Affiliations:
1. Kazan National Research Technological University
2. Federal Research Center for Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences
3. Kazan (Volga Region) Federal University
Issue: Vol 57, No 6 (2023)
Pages: 460-464
Section: RADIATION CHEMISTRY
URL: https://rjsvd.com/0023-1193/article/view/661464
DOI: https://doi.org/10.31857/S0023119323060013
EDN: https://elibrary.ru/QIXTHX
ID: 661464

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Abstract

The effect of γ-irradiation of the gelling agent Carbomer 141 G, which is lightly crosslinked polyacrylic acid, on the rheological properties of gels based on the carbomer has been studied. It has been found that an increase in the dose of γ-irradiation in air has a destructive effect on the polymer, leading to a decrease in rheological parameters, such as viscosity, yield strength, and hysteresis area. Irradiation of the carbomer in air with doses greater than 300 kGy leads to a significant decrease or the complete loss of its gel-forming properties. At the same time, irradiation of the carbomer with the same dose in vacuum causes as small a decline in viscosity as 2% compared to the initial systems. It has been established that the optimal gelling agent for obtaining stable antibacterial gels is the carbomer irradiated with a dose of 30 kGy.

Keywords

polyacrylic acid, carbomer, γ-irradiation, gel, rheological properties, viscosity, degradation

References

Анурова М.Н., Бахрушина Е.О., Демина Н.Б. // Химико-фармацевтический журнал. 2015. № 9. С. 39.
Muramatsu M., Kanada K., Nishida A., Ouchi K., Saito N., Yoshida M., Shimoaka A., Ozeki T., Yuasa H., Kanaya Y. // Int J Pharm. 2000. V. 199. P. 77.
Fiume M.M., Heldreth B., Boyer I., Bergfeld W.F., Belsito D.V., Hill R.A., Klaassen C.D., Liebler D.C., Marks J.G.Jr, Shank R.C., Slaga T.J., Snyder P.W., Andersen F.A. // Int. J. Toxicol. 2017. V. 36. P. 59S.
Филиппова О.Е. // Высокомолек. соед. 2000. Т. 42. С. 2328.
Khoury S.H.J., Da Silva M.I.B., Mansur C.R.E., Santos-Oliveira R. // Radiat. Phys. Chem. 2018. V. 145. P. 19.
SilindirM., Özer Y. // PDA J. Pharm Sci. and Tech. 2012. V. 66. P. 184.
Adams I., Davis S.S. // J. Pharm. Pharmacol. 1973. V. 25. P. 640.
Deshpande S., Shirolkar S. //J. Pharm. Pharmacol. 1989. V. 41. P. 197.
Sintzel M.B., Merkli A., Tabatabay C., Gurny R. // Drug Development and Industrial Pharmacy. 1997. V. 23. P. 857.
Шаймухаметова И.Ф., Шигабиева Ю.А., Богданова С.А., Аллаяров С.Р. // Химия высоких энергий. 2020. Т. 54. С. 122.
Allayarov S.R., Shaimukhametova I.F., Confer M.P., Bogdanova S.A., Shigabieva Y.A., Dixon D.A. // Polymer Degradation and Stability. 2021. V. 191. P. 109697.
Шрамм Г. // Основы практической реологии и реометрии / Пер. с англ. И.А. Лавыгина, под ред. В. Г. Куличихина. М.: Колос. 2003. 312 С.
Самченко Ю.М., Ульберг З.Р., Комарский С.А., Ковзун И.Г., Проценко И.Т. // Коллоидный журнал. 2003. Т. 65. С. 87.
Huszank R., Szilágyi E., Szoboszlai Z., Szikszai Z. // Nucl. Instruments Methods Phys. Res. Sect. B Beam Interact. Mater. Atoms. 2019. V. 450. P. 364.
Махлис Ф.А. // Атомная энергия. 1969. Т. 27. С. 323.