Toxicological assessment of the exposure to some arylheteroalkanecarboxylic compounds on the body

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Introduction. One of the current medical and social problems is the intoxication of the body of workers that occurs during the production of medicines in chemical-pharmaceutical enterprises. In this regard, it is necessary to substantiate and develop a hygienic rationing of the content of harmful substances in the air of the working area.

Materials and methods. Toxicity parameters (1-benzylindol-3-yl-thio) acetic acid (BTAA) and tris-(2-hydroxyethyl) ammonium-1-benzylindol-3-ylthioacetate (VM-7-02) were studied. Experimental studies were conducted on outbred rats and mice, rabbits and guinea pigs. Using standard physiological, biochemical, hematological and morphological parameters, the effect of the substance on the experimental animals was evaluated. The parameters of acute inhalation toxicity of substances were determined during the experiment in the chamber for inhalation primers using spectrophotometry to analyze the amount of the substance in the air of the chambers. Processing and interpretation of the information obtained was performed using the software package “Statistic 10.0”.

Results. In terms of mean lethal doses (DL50), both xenobiotics can be classified as moderately hazardous substances of hazard class III, and there are no specific species and sex differences in the sensitivity of animals to the substances under study. Local skin reaction and signs of resorption of substances through intact skin are absent. The irritant effect on the mucous membranes of the eyes of tris-(2-hydroxyethyl) ammonium-1-benzylindol-3-ylthioacetate can be classified as weak. The ability to material accumulation in the body of the compound VM-7-02 is medium: the cumulation coefficient is 3.7. At BTAA cumulative abilities are even weaker – the coefficient is equal to 5.1. In the subacute experiment, they have a toxic effect mainly on the hepatorenal system. The threshold of acute inhalation action of BTAA is 100.7, VM-7-02–57.8 mg/m3.

Conclusion. A tentative safe level of exposure to VM-7-02 in the air of the working area is recommended
at 0.3 mg/m3, BTAA is recommended at 2.0 mg/m3. Compliance with this standard will minimize the risk to the health of workers.

作者简介

Larisa Gorokhova

FSBSI “Research Institute for Complex Problems of Hygiene and Occupational Diseases”; Novokuznetsk Institute (Branch Campus) of FSBEI HE “Kemerovo State University”

编辑信件的主要联系方式.
Email: ponomarikova@mail.ru
ORCID iD: 0000-0002-0545-631X

Ph.D. in biological sciences, lead researcher of the laboratory of molecular-genetic and experimental researches, Research Institute for Complex Problems of Hygiene and Occupational Diseases,, Novokuznetsk, 654041, Russian Federation.

e-mail: ponomarikova@mail.ru

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A. Zhukova

FSBSI “Research Institute for Complex Problems of Hygiene and Occupational Diseases”; Novokuznetsk Institute (Branch Campus) of FSBEI HE “Kemerovo State University”

Email: noemail@neicon.ru
ORCID iD: 0000-0002-4797-7842
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N. Kizichenko

FSBSI “Research Institute for Complex Problems of Hygiene and Occupational Diseases”; Novokuznetsk Institute (Branch Campus) of FSBEI HE “Kemerovo State University”

Email: noemail@neicon.ru
ORCID iD: 0000-0001-5665-2604
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A. Kazitskaya

FSBSI “Research Institute for Complex Problems of Hygiene and Occupational Diseases”

Email: noemail@neicon.ru
ORCID iD: 0000-0001-8292-4810
俄罗斯联邦

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