The Role of rs2238296 of the Mitochondrial DNA Polymerase Gamma Gene in Combination with Polymorphic Variants of Antioxidant Defense Genes in the Development of Postinfarction Left Ventricular Aneurysm

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Abstract

Studied the relationship of the polymorphic variant of the mitochondrial DNA polymerase gamma gene (POLG rs2238296) in combination with single-nucleotide polymorphic variants of the genes of the antioxidant system of the body (mitochondrial transcription factor A (TFAM rs1937), superoxide dismutase (SOD2 rs4880), glutathione peroxidase (GPX1 rs1050450), catalase (CAT rs1001179), paraoxonase 1 (PON1 rs854560) and NADP-H oxidase (CYBA rs4673)) with features of postinfarction remodeling of the left ventricle (LV). One hundred and fifty-three patients with coronary heart disease (137 men and 16 women) aged 56 (50; 60.5) years were examined. Genotyping was carried out using a polymerase chain reaction followed by analysis of the polymorphism of the lengths of restriction fragments. No significant difference was found in the SOD2, GPX1, CAT, PON1, TFAM genes in the studied groups. Significant differences were found with respect to the POLG and CYBA genes: the CC rs2238296 genotype of the POLG gene was found in every third patient with LV aneurysm (30.3%), where as in the group without aneurysm – only in every eighth case (12.3%, p = 0.006). The CC rs4673 genotype of the CYBA gene was found in every second patient with an aneurysm (51.8%) and in 32% without LV aneurysm (p = 0.01). Patients with a combination of CC (POLG) and CC (CYBA) genotypes were represented exclusively by younger men, who were characterized by a less burdened comorbid background, in comparison with patients with a different genotype of these genes. At the same time, the LV ejection fraction in such patients was significantly lower (40 (27; 52) and 50 (40; 61), p = = 0.006), and the development of LV aneurysm was recorded in 73% of cases.

About the authors

E. A. Kuzheleva

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Author for correspondence.
Email: kea@cardio-tomsk.ru
Russia, 634012, Tomsk

A. A. Garganeeva

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: kea@cardio-tomsk.ru
Russia, 634012, Tomsk

O. V. Tukish

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: kea@cardio-tomsk.ru
Russia, 634012, Tomsk

A. K. Nesova

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: kea@cardio-tomsk.ru
Russia, 634012, Tomsk

M. V. Golubenko

Scientific Research Institute of Medical Genetics, Tomsk National Research Medical Center
of the Russian Academy of Sciences

Email: kea@cardio-tomsk.ru
Russia, 634050, Tomsk

S. L. Andreev

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: kea@cardio-tomsk.ru
Russia, 634012, Tomsk

V. M. Shipulin

Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences

Email: kea@cardio-tomsk.ru
Russia, 634012, Tomsk

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Copyright (c) 2023 Е.А. Кужелева, А.А. Гарганеева, О.В. Тукиш, А.К. Несова, М.В. Голубенко, С.Л. Андреев, В.М. Шипулин