Measurement of advanced glycation end products in the skin using autofluorescence spectroscopy in patients with chronic kidney disease


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Abstract

Purpose. Determination of the diagnostic capabilities of use of the device «Skin-AGE» in patients with kidney disease. Material and methods. Three groups of patients were evaluated: Group 1 (control group) consisted of practically healthy persons (47; F/M: 32/15, AGE: 16-78 years), Group 2 - renal transplant recipients (RTR; 24 persons; F/M: 13/11, AGE: 15-62 years), Group 3 - patients with end-stage renal failure (esrf) on the permanent hemodialysis(79; F/M: 35/44, AGE: 22-82 years). Level of tissue accumulation of advanced glycation end products (agep) in theskin was estimated according to the intensity of autofluorescence (AF) using the device «Skin-AGE», developed in FSPb SMU n.a. Acad. I.P. Pavlov. Results. Comparison of the data obtained using the device «Skin-AGE», with the results from healthy individuals using the known device «age reader» (diagnoptics, netherlands), has showed that in both cases were similar age trends. The coefficient of correlation with age obtained using the device «AGE-reader» was 0.32 (p <0.05), and using our divice «skin-age» - 0.74 (p <0.001). in group 2 and group 3, increase of the average values of af was observed compared to the normal parameters by 1.75 ± 0.16 and 1.42 ± 0.16 times, respectively. in patients with esrf, marked significant direct correlations of af with the duration of dialysis (R = 0.36; P <0.0005), hemoglobin levels in peripheral blood (0.20; p <0.05) and calcium-phosphorus product (r = 0.24; p <0.025) were revealed. In RTR, a significant inverse relationship between AF and the duration of previous dialysis (r = -0.43; p <0.025), as well as direct correlation of AF with of total cholesterol levels (r = 0.36; p <0.05), low density lipoprotein cholesterol levels (R = 0,40; P <0.025) were revealed. Conclusion. Measurements of tissue accumulation of AGEP according to AF levels using the device «Skin-AGE» can be used in the evaluation of patients with chronic kidney disease.

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