Vol 13, No 2 (2010)

The paper presents the comparative results of photodynamic therapy (PDT) in 60 patients with basal-cell carcinoma (BCC) depending on the route of administration with the photosensitizer (PS) Photoditasine. The efficiency of BCC treatment has been found to depend on the route of administration of the PS and to yield the best results when locally used. It is noted that PDT with the intrafocal administration of the PS Photoditasine leads to the recovery of stages T1 and T2 nodular BCC in 100% of cases; moreover, it induces no systemic adverse reactions, requires no light regimen observance, significantly reduces the time of wound healing, and provides excellent and good cosmetic results significantly more frequently.

The expression of StAR and peripheral benzodiazepine receptor (PBR) was studied in the skin of patients with melanoma and in those with benign melanocytic nevi. The presence of StAR was first determined in the skin of patients with this abnormality. There was a reduction in the expression of StAR and PBR as compared with the indices of normal epidermis.

The paper provides data on the detection of antibodies to M. leprae during an immunochemical study of acute-phase proteins in patients with lepromatous lepra with the development of lepra reactions.

The paper presents the results of complex therapy in patients with desquamative lesions of the skin, by using enterosorbents and immunomodulators.

The paper considers the etiopathogenesis of rosacea. It details the composition of 0.75% Rosex cream used to treat rosacea and the mechanism of its action. The results of treatment in 22 patients are given.

The authors analyze the structure of sarcoidosis morbidity on the basis of clinicomorphological monitoring of patients with different forms from Moscow and the Moscow region. They consider the specific features of the morpho- and immunogenesis of granulomatous inflammation in sarcoidosis, which result in a significant fibrotic process and evolving cosmetic defects. The clinical efficacy of Egallohit (as cream and gel) has been evaluated in 35 patients with sarcoidosis of the skin. The paper shows the efficacy of the agent and provides evidence that it is expedient to include it into cutaneous sarcoidosis treatment regimens to prevent the fibrotic processes leading to the development of cosmetic defects.

The paper describes a clinical case of smooth skin microsporia with unusual symptomatology in an 8-year-old child as a result of misdiagnosis of this mycosis.

The data available in the literature suggest that in the past decades visceral involvements in syphilis, which result in death, have become a rarity. The present paper analyzes a clinical case of syphilitic involvement of the pulmonary and cardiovascular systems with a fatal outcome, which was diagnosed postmortem, only at the patient's autopsy.

The paper presents the current information on the mechanisms of damaging action of ultraviolet irradiation on the skin, shows the basic differences of photoaging (PA) from natural skin aging. Particular emphasis is placed on the problem of suntan in the solaria. The methods for the prevention and treatment of PA are also described.