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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Skin and Venereal Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Skin and Venereal Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский журнал кожных и венерических болезней</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9588</issn><issn publication-format="electronic">2412-9097</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">87993</article-id><article-id pub-id-type="doi">10.17816/dv87993</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DERMATOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДЕРМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Modern concepts of erythematotelangiectatic rosacea pathogenesis and treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Современные представления о патогенезе и лечении эритематозно-телеангиэктатического субтипа розацеа</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7968-7663</contrib-id><contrib-id contrib-id-type="spin">3785-7859</contrib-id><name-alternatives><name xml:lang="en"><surname>Snarskaya</surname><given-names>Elena S.</given-names></name><name xml:lang="ru"><surname>Снарская</surname><given-names>Елена Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>snarskaya-dok@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0861-3800</contrib-id><name-alternatives><name xml:lang="en"><surname>Rusina</surname><given-names>Tatiana S.</given-names></name><name xml:lang="ru"><surname>Русина</surname><given-names>Татьяна Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>rusina@cidk.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Central Institute of Dermatocosmetology</institution></aff><aff><institution xml:lang="ru">Центральный институт дерматокосметологии</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2021</year></pub-date><volume>24</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>367</fpage><lpage>374</lpage><history><date date-type="received" iso-8601-date="2021-11-14"><day>14</day><month>11</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-11-21"><day>21</day><month>11</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Эко-Вектор"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-08-01"/></permissions><self-uri xlink:href="https://rjsvd.com/1560-9588/article/view/87993">https://rjsvd.com/1560-9588/article/view/87993</self-uri><abstract xml:lang="en"><p>Rosacea is a multifactorial chronic pathology characterized by a complex etiopathogenesis. Rosacea is represented by 4 subtypes: erythematotelangiectatic, papulopustular, rhinophyma and ophthalmic rosacea.</p> <p>Clinical manifestations of erythematotelangiectatic rosacea reduce the quality of human life, which is manifested by disorders of the psychoemotional sphere of varying severity. The erythematotelangiectatic subtype is influenced by two groups of trigger factors ― internal and external.</p> <p>Mandatory areas of patients management with rosacea in general include the “triad of treatment”: providing proper skin care, health education, a set of therapeutic measures.</p> <p>Rosacea drug therapy is divided into local and systemic. The main treatment for erythematotelangiectatic rosacea is to eliminate the vascular component and reduce the severity of transient and persistent erythema.</p> <p>Among the physiotherapeutic methods, the most promising today are considered to be laser therapy and an intense pulsed light system (IPL). The effectiveness of laser medicine in dermatology is due to the ability to selectively build up the laser of the chromophochic layer of the dermis. The mechanism of action of IPL-therapy is associated with the absorption of photons by internal or external chromophores, which are located in different layers of the skin, which can locally increase the temperature and cause destructed target formations.</p> <p>A review of the literature on pathogenesis, trigger factors, classification and modern treatment of eerythematotelangiectatic rosacea is based on an analysis of articles on the relevant topic 44 presented in information systems electronic library, PubMed, NCBI, Embase. Studies are described demonstrating the convincing effectiveness of the treatment of patients with lasers and the IPL system.</p></abstract><trans-abstract xml:lang="ru"><p>Розацеа представляет собой достаточно сложную, многофакторную, хроническую, устойчивую к терапевтическим мероприятиям патологию, которая характеризуется сложным этиопатогенезом. Учитывая основные и дополнительные признаки заболевания, описаны 4 субтипа розацеа: эритематозно-телеангиэктатический, папулопустулярный, ринофима и офтальморозацеа.</p> <p>Клинические проявления эритематозно-телеангиэктатического субтипа розацеа снижают качество жизни человека, что проявляется нарушениями психоэмоциональной сферы разной степени выраженности. На формирование такого субтипа розацеа оказывают влияние две группы факторов ― эндогенные (внутренние) и экзогенные (внешние).</p> <p>Обязательные направления ведения больных розацеа в целом включают «триаду лечения»: обеспечение надлежащего ухода за кожей, санитарно-просветительная работа, комплекс лечебных мероприятий.</p> <p>Лекарственную терапию розацеа делят на наружную (местную) и системную. Основное лечение при эритематозно-телеангиэктатическом субтипе заключается в устранении сосудистого компонента и уменьшении выраженности преходящей и стойкой эритемы.</p> <p>Среди физиотерапевтических методик наиболее перспективными на сегодняшний момент считаются лазерная терапия и система интенсивного импульсного света (intense pulsed light, IPL). Эффективность лазерной медицины в дерматологии обусловлена способностью селективного поглощения лазера хромофорами сосочкового слоя дермы. Механизм действия IPL-терапии связан с абсорбцией фотонов эндогенными или экзогенными хромофорами, которые располагаются в разных слоях кожи, и передаче им энергии, способной локально повышать температуру и вызывать деструкцию образований-мишеней.</p> <p>Обзор литературы по патогенезу, триггерным факторам, классификации и современному лечению эритематозно-телеангиэктатического субтипа розацеа основан на анализе соответствующих данной тематике 44 статей, представленных в информационных системах eLibrary, PubMed, NCBI, Embase. Описаны исследования, демонстрирующие убедительную эффективность лечения больных с помощью лазеров и системы IPL.</p></trans-abstract><kwd-group xml:lang="en"><kwd>skin</kwd><kwd>rosacea</kwd><kwd>teleangectasia</kwd><kwd>topical therapy</kwd><kwd>broadband pulse light</kwd><kwd>IPL-therapy</kwd><kwd>brimonidine</kwd><kwd>0.5% brimonidine gel tartrate</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>розацеа</kwd><kwd>эритема</kwd><kwd>телеангиэктазии</kwd><kwd>широкополосное импульсное световое излучение</kwd><kwd>IPL-терапия</kwd><kwd>0,5%-ный гель бримонидина тартрат</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Rainer BM, Fischer AH, Luz Felipe da Silva D, et al. Rosacea is associated with chronic systemic diseases in a skin severity-dependent manner: results of a case-control study. 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