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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Skin and Venereal Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Skin and Venereal Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский журнал кожных и венерических болезней</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9588</issn><issn publication-format="electronic">2412-9097</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">78255</article-id><article-id pub-id-type="doi">10.17816/dv78255</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DERMATOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДЕРМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Blister beetle bites: a case report</article-title><trans-title-group xml:lang="ru"><trans-title>Укусы жуков-нарывников: клинический случай</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2482-1754</contrib-id><contrib-id contrib-id-type="spin">2500-7989</contrib-id><name-alternatives><name xml:lang="en"><surname>Olisova</surname><given-names>Olga Yu.</given-names></name><name xml:lang="ru"><surname>Олисова</surname><given-names>Ольга Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>olisovaolga@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5800-4800</contrib-id><contrib-id contrib-id-type="spin">8013-3256</contrib-id><name-alternatives><name xml:lang="en"><surname>Teplyuk</surname><given-names>Natalia P.</given-names></name><name xml:lang="ru"><surname>Теплюк</surname><given-names>Наталия Павловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>teplyukn@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1930-0073</contrib-id><name-alternatives><name xml:lang="en"><surname>Tavitova</surname><given-names>Alana R.</given-names></name><name xml:lang="ru"><surname>Тавитова</surname><given-names>Алана Руслановна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>alatavitova@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7271-3910</contrib-id><name-alternatives><name xml:lang="en"><surname>Shamilova</surname><given-names>Lyaman F.</given-names></name><name xml:lang="ru"><surname>Шамилова</surname><given-names>Ляман Фаризовна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Graduate Student</p></bio><bio xml:lang="ru"><p>аспирант</p></bio><email>lyaman.doc@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-07-15" publication-format="electronic"><day>15</day><month>07</month><year>2021</year></pub-date><volume>24</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>387</fpage><lpage>394</lpage><history><date date-type="received" iso-8601-date="2021-08-18"><day>18</day><month>08</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-12-02"><day>02</day><month>12</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Эко-Вектор"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-08-01"/></permissions><self-uri xlink:href="https://rjsvd.com/1560-9588/article/view/78255">https://rjsvd.com/1560-9588/article/view/78255</self-uri><abstract xml:lang="en"><p>Contacts with insects of the order coleoptera of the families Meloidae and Oedemeridae, in particular the bites of the abscess beetle, lead to acantholysis and the formation of intraepidermal blisters, as well as nonspecific skin damage. The family Meloidae (true abscess beetles) are distributed almost everywhere, with the exception of the territories of New Zealand, Antarctica and the Polynesian islands.</p> <p>Insect species of the Meloidea family have a unique life cycle. Meloidae females lay eggs not only on coleoptera larvae, but also on any other insects, such as crickets, mantises, wasps, bees, on which their metamorphosis continues in the future. Populations of abscess beetles number a large number of individuals, which increases the risk of their meeting with humans. These species have a highly toxic colorless and odorless poison of non-protein nature ― cantharidin.</p> <p>There is a rare clinical case of an abscess beetle bite. The debut of the disease occurred at the time of the patient’s trip to the island of Goa (India), where he noted insect bites with the appearance of the first blistering rashes and further progression of the skin process. The primary diagnosis was complicated by nonspecific changes detected during the pathomorphological examination of the skin, in the form of subacute dermatitis without classical manifestations of acantholysis with intradermal blisters due to delayed biopsy appointment. Against the background of ongoing treatment (prednisone; corrective therapy with potassium, magnesium, calcium, gastroprotectors; antibiotics; nonsteroidal anti-inflammatory and antimycotic drugs; combined topical glucocorticoids; a course of systemic autohemoozonotherapy) from the skin process, positive dynamics was noted in the form of relief of inflammatory phenomena, partial epithelization of wound defects.</p> <p>Secondary infection of rashes, accompanied, as in this case, by abscessing, is often found with bites of various insect families: cases up to the development of necrotic fasciitis with a fatal outcome are described.</p> <p>The described case is of clinical, scientific and epidemiological interest due to the isolated publications on this nosology and the complexity of diagnosis. Knowledge of the clinical picture of the disease will allow practitioners to develop tactics for managing patients with timely selection of effective therapy.</p></abstract><trans-abstract xml:lang="ru"><p>Контакты с насекомыми отряда жесткокрылых семейств Meloidae и Oedemeridae, в частности укусы жука-нарывника, приводят к акантолизу и формированию интраэпидермальных пузырей, а также неспецифическому повреждению кожи. Семейство Meloidae (настоящие жуки-нарывники) распространены практически повсеместно, за исключением территорий Новой Зеландии, Антарктиды и полинезийских островов.</p> <p>Виды насекомых семейства Meloidea имеют уникальный жизненный цикл. Самки Meloidae откладывают яйца не только на личинках жесткокрылых, но и любых других насекомых, таких как сверчки, богомолы, осы, пчёлы, на которых в дальнейшем и продолжается их метаморфоз. Популяции жуков-нарывников насчитывают большое количество особей, что увеличивает риск их встречи с человеком. Эти виды обладают высокотоксичным бесцветным и непахучим ядом небелковой природы ― кантаридином.</p> <p>Приводим редкий клинический случай укуса жука-нарывника. Дебют заболевания пришёлся на момент поездки пациента на остров Гоа (Индия), где он отмечал укусы насекомого с возникновением первых пузырных высыпаний и дальнейшим прогрессированием кожного процесса. Первичная диагностика была затруднена неспецифическими изменениями, обнаруженными при патоморфологическом исследовании кожи, в виде подострого дерматита без классических проявлений акантолиза с интрадермальными пузырями вследствие отсроченного назначения биопсии. На фоне проводимого лечения (преднизолон; корригирующая терапия препаратами калия, магния, кальция, гастропротекторов; антибиотики; нестероидные противовоспалительные и антимикотические препараты; комбинированные топические глюкокортикоиды; курс системной аутогемоозонотерапии) со стороны кожного процесса отмечалась положительная динамика в виде купирования островоспалительных явлений, частичной эпителизации раневых дефектов.</p> <p>Вторичное инфицирование высыпаний, сопровождающееся, как в данном случае, абсцедированием, нередко встречается при укусах различных семейств насекомых: описаны случаи вплоть до развития некротического фасциита с фатальным исходом.</p> <p>Описанный случай представляет клинико-научный и эпидемиологический интерес в связи с единичными публикациями по данной нозологии и сложностью диагностики. Знание клинической картины заболевания позволит практикующим врачам выработать тактику ведения пациентов со своевременным подбором эффективной терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>blister beetle</kwd><kwd>blister beetle bites</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>жуки-нарывники</kwd><kwd>укусы жуков-нарывников</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">William D, James MD, Elston MD, et al. Andrews’ diseases of the skin: clinical dermatology. 13th Edition. 2019.</mixed-citation><mixed-citation xml:lang="ru">William D., James M.D., Elston M.D., et al. Andrews’ diseases of the skin. Clinical dermatology. 13th Edition. 2019.</mixed-citation></citation-alternatives></ref><ref id="B2"><label>2.</label><citation-alternatives><mixed-citation xml:lang="en">Ghoneim KS. 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