Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector6652710.17816/dv66527Research ArticleStudy of the influence of fractional photothermolysis and biorevitalization on skin rejuvenation in middle aged womenKudrevichYuliya V.<p>MD, Cand. Sci. (Med.); Associate Professor</p>cyton@mail.ruhttps://orcid.org/0000-0002-8867-0775KuznetsovaEvgeniya K.<p>MD, Cand. Sci. (Med.), Associate Professor</p>estroukova@ya.ruhttps://orcid.org/0000-0001-8670-2828ZiganshinOleg R.<p>MD, Dr. Sci. (Med.)</p>ziganshin_oleg@mail.ruhttps://orcid.org/0000-0001-8480-1427ZayatcTatiana A.90583399@mail.ruhttps://orcid.org/0000-0002-9283-930XSouth-Ural State Medical UniversityOrenburg State Medical University131020222532392462804202113082022Copyright © 2022, Eco-Vector2022<p><em><strong>BACKGROUND</strong></em>:There is a fairly high demand of patients for procedures to improve the appearance and rejuvenation of the skin, while the methods used have a different, often aggressive principle of action, requiring a long period of rehabilitation.</p>
<p><em><strong>AIM</strong></em>:The purpose of the work was to determine the safety and effectiveness of exposure to the skin in order to improve its quality and rejuvenate such methods as biorevitalization and fractional photothermolysis using an erbium laser, to determine changes in the structural components of the skin that affect its condition, before and after exposure to various types of procedures.</p>
<p><em><strong>MATERIALS AND METHODS</strong></em>:40 patients were examined, who were divided into two groups. Patients of the first group received the biorevitalization procedure, the second group of patients underwent fractional photothermolysis. A fragment of skin was taken from all patients before and after the procedures and the volumetric density of collagen types I and III, laminin, growth factors (VEGF, FGF, TGF, IGF) in the dermis and epidermis, interleukins (IL-4, IL-1) in the dermis and epidermis was assessed. We assessed the level of changes in these indicators before and after procedures in different groups, correlation analysis.</p>
<p><em><strong>RESULTS</strong></em>:An increase in the volumetric density of collagens, laminin, growth factors, interleukins was recorded, but the correlations in different groups were different. The structural parameters of the skin during biorevitalization positively correlated with growth factors, and with fractional photothermolysis with indicators of local immunity, such as interleukins, TGF.</p>
<p><em><strong>CONCLUSION</strong></em>:It was concluded that both biorevitalization and laser exposure have a positive effect on the quality of the skin, but in the case of revitalization, these changes occur through the stimulating action of hyaluronic acid, the entrainment of growth factors in the skin, and in the case of fractional photothermolysis, the formation of new collagen, strengthening of the dermo-epidermal connections occur through the processes of inflammation and regeneration.</p>biorevitalizationfractional photothermolysisskin rejuvenationcollagengrowth factorsinterleukinsбиоревитализацияфракционный фототермолизомоложение кожиколлагенфакторы ростаинтерлейкины[Deglesne PA, Arroyo R, Ranneva E, Deprez P. In vitro study of RRSHA injectable mesotherapy/biorevitalization product on human skin fibroblasts and its clinical utilization. Clin Cosmet Investig Dermatol. 2016;9:41–53. doi: 10.2147/CCID.S95108][Palmieri A, Avantaggiato A, Cura, F, et al. Biorevitalization: an in vitro study on gingival fibroblast. J Biol Regul Homeost Agents. 2017;31(4 Suppl 2):147–153.][El-Domyati M, El-Ammawi TS, Medhat W, et al. Expression of transforming growth factor-β after different non-invasive facial rejuvenation modalities. Int J Dermatol. 2015;54(4):396–404. doi: 10.1111/ijd.12435][Hong L, Shen M, Fang J, et al. Hyaluronic acid (HA)-based hydrogels for full-thickness wound repairing and skin regeneration. J Mater Sci Mater Med. 2018;29(9):150. doi: 10.1007/s10856-018-6158-x][Avantaggiato A, Girardi A, Palmieri A, et al. Bio-revitalization: effects of NASHA on genes involving tissue remodeling. Aesthetic Plast Surg. 2015;39(4):459–464. doi: 10.1007/s00266-015-0514-8]