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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Skin and Venereal Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Skin and Venereal Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский журнал кожных и венерических болезней</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9588</issn><issn publication-format="electronic">2412-9097</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">61804</article-id><article-id pub-id-type="doi">10.17816/dv61804</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>CLINICAL PICTURE, DIAGNOSIS, AND THERAPY OF DERMATOSES</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>КЛИНИКА, ДИАГНОСТИКА И ЛЕЧЕНИЕ ДЕРМАТОЗОВ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Prevalence and etiology of onychomycosis in patients with psoriasis: a single-center study</article-title><trans-title-group xml:lang="ru"><trans-title>Распространённость и этиология онихомикоза у больных псориазом: одноцентровое исследование</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7136-4053</contrib-id><name-alternatives><name xml:lang="en"><surname>Kochergin</surname><given-names>Nikolay G.</given-names></name><name xml:lang="ru"><surname>Кочергин</surname><given-names>Николай Георгиевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>nkocha@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2850-2910</contrib-id><name-alternatives><name xml:lang="en"><surname>Maximov</surname><given-names>Ivan S.</given-names></name><name xml:lang="ru"><surname>Максимов</surname><given-names>Иван Сергеевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Assistant</p></bio><bio xml:lang="ru"><p>ассистент</p></bio><email>maximov.is@mail.ru</email><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff><aff><institution xml:lang="zh"></institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2021-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2021</year></pub-date><volume>24</volume><issue>1</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>53</fpage><lpage>59</lpage><history><date date-type="received" iso-8601-date="2021-02-25"><day>25</day><month>02</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-03-17"><day>17</day><month>03</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2021, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2021, ООО "Эко-Вектор"</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2025-08-01"/></permissions><self-uri xlink:href="https://rjsvd.com/1560-9588/article/view/61804">https://rjsvd.com/1560-9588/article/view/61804</self-uri><abstract xml:lang="en"><p><bold><italic>BACKGROUND: </italic></bold>Changes in nails with psoriasis are observed in 80–90% of patients. Pathological processes in the nail apparatus in patients with psoriasis are associated with both the underlying disease and the infectious nature.</p> <p><bold><italic>AIMS:</italic></bold> To evaluate the clinical features of the affected nail plates in patients with psoriasis, the prevalence and etiology of onychomycosis in patients with psoriasis with altered nail plates.</p> <p><bold><italic>MATERIALS AND METHODS: </italic></bold>102 patients with psoriasis vulgaris, mild and moderate, stationary stage with altered nail plates were examined. A clinical and laboratory (microscopic and cultural) study of the affected nail plates was carried out.</p> <p><bold><italic>RESULTS: </italic></bold>After mycological studies and physical examination of the affected nails of 102 patients, the following groups of nail diseases in patients with psoriasis were identified: psoriatic onychodystrophy (76; 74.5%) patients, onychomycosis (30; 29.4%) patients, traumatic onycholysis (4; 3,9%) patient, onychocryptosis (3; 2.9%) patients. 11 (14.5%) patients with psoriatic onychodystrophy had a complication in the form of a fungal infection. Distal-lateral subungual form of onychomycosis was detected in 17 patients (56.7%), total dystrophic form ― in 10 patients (33.3%), white superficial form ― in 2 patients (6.6%), proximal subungual form ― in 1 patient (3.3%).</p> <p><bold><italic>CONCLUSIONS:</italic></bold> According to the results of clinical and mycological examination of the affected nails of patients with psoriasis, it was revealed that 74.5% of patients have manifestations of psoriatic onychodystrophy, 29.4% ― onychomycosis. Among patients with psoriatic onychodystrophy, 14.5% had a complication in the form of a secondary fungal infection. The main causative agents of onychomycosis are Candida spp. (63.3%). The incidence of dermatophytes (<italic>Trichophyton</italic> spp.) Was 36.7% of the total number of cases. The main clinical forms of onychomycosis in patients with psoriasis are distal-lateral (56.6%), total dystrophic (33.3%).</p></abstract><trans-abstract xml:lang="ru"><p><bold><italic>Обоснование.</italic></bold> Изменение ногтей при псориазе наблюдается у 80–90% пациентов. Патологические процессы в ногтевом аппарате у больных псориазом могут быть связаны как с основным заболеванием, так и иметь инфекционную природу.</p> <p><bold><italic>Цель</italic> </bold>― оценить клинические особенности поражённых ногтевых пластин у больных псориазом, распространённость и этиологию онихомикоза у больных псориазом с изменёнными ногтевыми пластинами.</p> <p><bold><italic>Материал и методы.</italic></bold> Обследовано 102 больных вульгарным псориазом, лёгкой и средней степени тяжести, стационарной стадии, с изменёнными ногтевыми пластинами. Проведено клиническое и лабораторное (микроскопическое и культуральное) исследование поражённых ногтевых пластин.</p> <p><bold><italic>Результаты.</italic> </bold>После проведённых микологических исследований и физикального обследования поражённых ногтей выделены следующие группы заболеваний ногтей у больных псориазом: псориатическая ониходистрофия (у 76; 74,5%), онихомикоз (у 30; 29,4%), травматический онихолизис (у 4; 3,9%), онихокриптоз (у 3; 2,9%).У 11 (14,5%) больных псориатической ониходистрофией было осложнение в виде присоединения грибковой инфекции. Дистально-латеральная подногтевая форма онихомикоза была выявлена в 17 (56,7%) случаях, тотально-дистрофическая форма ― в 10 (33,3%), белая поверхностная форма ― в 2 (6,6%), проксимальная подногтевая форма ― в 1 (3,3%).</p> <p><bold><italic>Заключение.</italic></bold> По результатам клинико-микологического обследования поражённых ногтей больных псориазом выявлено, что 74,5% пациентов имеют проявления псориатической ониходистрофии, 29,4% ― онихомикоза. Среди больных псориатической ониходистрофией в 14,5% случаев в качестве осложнения отмечалось присоединение вторичной грибковой инфекции. Основными возбудителями онихомикоза являются грибы <italic>Candida</italic> spp. (63,3%). Частота встречаемости дерматофитов (<italic>Trichophyton</italic> spp.) ― 36,7% от общего числа случаев. Основные клинические формы онихомикоза у больных псориазом ― дистально-латеральная (56,6%), тотально-дистрофическая (33,3%).</p></trans-abstract><kwd-group xml:lang="en"><kwd>onychomycosis</kwd><kwd>psoriasis</kwd><kwd>psoriatic onychodystrophy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>онихомикоз</kwd><kwd>псориаз</kwd><kwd>псориатическая ониходистрофия</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Suskova VS, Pinson IYa, Olisova OYu. Immunopathological mechanisms of psoriasis. Russian Journal of Clinical Dermatology and Venereology. 2006;4(1):68-70. (in Russ)</mixed-citation><mixed-citation xml:lang="ru">Сускова В.С., Пинсон И.Я., Олисова О.Ю. Иммунопатогенез псориаза. Клиническая дерматология и венерология. 2006. Т. 4, № 1. 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