Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector4295310.17816/dv42953Research ArticleCLINICAL CASE OF PYODERMA GANGRENOSUMGrabovskayaO. V-TeplyukN. P-KusraevaDiana T.postgraduate of Department of skin and venereal diseases of I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russian Federationkysra1992@mail.ruVarshavskyV. A-I.M. Sechenov First Moscow State Medical University (Sechenov University)15122019225-616116624082020Copyright © 2019, Eco-Vector2019The results of clinical observation of a rare dermatosis, pyoderma gangrenosum, and results of successful complex treatment of the disease with systemic GCS, and cytostatic drugs are shown. The review of the literature on the etiology, pathogenesis, and diagnosis of GP is presented.pyoderma gangrenosumneutrophilic dermatosesclinical caseгангренозная пиодермиянейтрофильные дерматозыслучай клинического наблюдения[Олисова О.Ю., Теплюк Н.П., ред. Дерматологический атлас. М.: Геотар-медиа; 2015.][Олисова О.Ю., ред. Кожные и венерические болезни. М.: Практическая медицина; 2015.][Fayyaz B. Pyoderma gangrenosum in primary care setting: the challenges involved. J. Community Hosp. Intern. Med. Perspect. 2018; 8(2): 57-9.][Елькин В.Д., Митрюковский Л.С., Плотникова Е.В. Современные представления о гангренозной пиодерми. Терапевтический архив. 2014; 86(12): 121-6.][Голдсмит Л.А., Кац С.И., Джилкрест Б.А., Паллер Э.С., Леффель Д.Д., Вольф К., ред. Дерматология Фицпатрика в клинической практике. Пер. с англ. М.: Издательство Панфилова; 2016: т. 2: 382-419.][Marzano A.V., Ortega-Loayza A.G., Heath M., Morse D., Genovese G., Cugno M. Mechanisms of inflammation in neutrophil-mediated skin diseases. Front. Immunol. 2019;10:1059. doi:10.3389/fimmu.2019.01059][DeFilippis E.M., Feldman S.R., Huang W.W. The genetics of pyoderma gangrenosum and implications for treatment: a systematic review. Br. J. Dermatol. 2015; 172(6): 1487-97.][Marzano A.V., Damiani G., Ceccherini I., Berti E., Gattorno M., Cugno M. Autoinflammation in pyoderma gangrenosum and its syndromic form (pyoderma gangrenosum, acne and suppurative hidradenitis). Br. J. Dermatol. 2017; 176(6): 1588-98.][Prat L., Bouaziz J.D., Wallach D., Vignon-Pennamen M.D., Bagot M. Neutrophilic dermatoses as systemic diseases. Clin. Dermatol. 2014; 32(3): 376-88.][Isailovic N., Daigo K., Mantovani A., Selmi C. Interleukin-17 and innate immunity in infections and chronic inflammation. J. Autoimmun. 2015; 60: 1-11. doi: 10.1016/j.jaut.2015.04.006.][Ковальчук Л.В., Свитич О.А., Ганковская Л.В., Мироншиченкова А.М., Ганковский В.А. Роль Toll-подобных рецепторов в патогенезе инфекционных заболеваний человека. Курский научно-практический вестник «Человек и его здоровье». 2012; (2): 147-53.][Barbosa N.S., Tolkachjov S.N., El-Azhary R.A., Davis M.D., Camilleri M.J., McEvoy M.T., et al. Clinical features, causes, treatments, and outcomes of peristomal pyoderma gangrenosum (PPG) in 44 patients: The Mayo Clinic experience, 1996 through 2013. J. Am. Acad. Dermatol. 2016; 75(5): 931-9.][Shavit E., Alavi A., Sibbaid R.G. Pioderma gangrenosum: A critical appraisal. Adv. Skin Wound Care. 2017; 30(12): 534-42.][Osaka A., Ide H., Ban S., Takimoto T., Aoki K., Kobori Y., et al. Pyoderma gangrenosum after radical prostatectomy: case report. Int. Cancer Conf. J. 2018; 7(3): 114-6.][Lemos A.C., Aveiro D., Santos N., Marques V., Pinheiro L.F. Pyoderma gangrenosum: an uncommon case report and review of the literature. Wounds. 2017; 29(9): E61-9.][Billings S.D. Common and critical inflammatory dermatoses every pathologist should know. Mod. Pathol. 2020; 33(Suppl.1): 107-17. Available at: http://www.nature.com/articles/s41379-019-0400-z][Saffie M.G., Shroff A. A case of pyoderma gangrenosum misdiagnosed as necrotizing infection: A potential diagnostic catastrophe. Case Rep. Infect. Dis. 2018; 2018: 1-5.][Saffie M.G., Shroff A. A case of pyoderma gangrenosum misdiagnosed as necrotizing infection: A potential diagnostic catastrophe. Case Rep. Infect. Dis. 2018; 2018: 8907542. doi: 10.1155/2018/8907542][Седов В.М., Андреев Д.Ю., Парамонов Б.А., Мухтарова А.М., Клюжник А.Ю. Гангренозная пиодермия как хирургическая проблема. Вестник хирургии им. И.И. Грекова. 2010; 169(3): 111-6.][Jain A.G., Sharbatji M., Afzal A., Afridi S.M., Gordon D. Pyoderma gangrenosum in the absence of any underlying predisposing condition: A diagnostic dilemma. Cureus. 2019; 11(3): e4213. doi:10.7759/cureus.4213]