Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal DiseasesРоссийский журнал кожных и венерических болезней1560-95882412-9097Eco-Vector4295010.17816/dv42950ArticlesСтатьиReview ArticleHUMAN PAPILLOMAVIRUS AS AN EPIGENETIC COFACTOR OF THE DEVELOPMENT OF SEVERAL EPITHELIAL NON-MELANOCYTIC SKIN NEOPLASMS (LITERATURE REVIEW)ВИРУС ПАПИЛЛОМЫ ЧЕЛОВЕКА КАК ЭПИГЕНЕТИЧЕСКИЙ КОФАКТОР РАЗВИТИЯ РЯДА ЭПИТЕЛИАЛЬНЫХ НЕМЕЛАНОЦИТАРНЫХ НОВООБРАЗОВАНИЙ КОЖИ (ОБЗОР ЛИТЕРАТУРЫ)Avad Zhaber Mahmud Zhaber-Авад Жабер Махмуд Жабер-

Department of Dermatology and Venereology, I. M. Sechenov First Moscow State Medical University, Moscow, 119991, Russian Federation

аспирант кафедры кожных венерических болезней ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет). 119991, г. Москва, Россия

jaberawad1987@yahoo.comSnarskayaE. SСнарскаяЕ. СDepartment of Dermatology and Venereology of I.M. Sechenov First Moscow State Medical University (Sechenov University)ФГАОУ ВО «Первый Московский государственный медицинский университет им. И.М. Сеченова» Минздрава России (Сеченовский университет)15122019225-6VOL 22, NO5-6 (2019)ТОМ 22, №5-6 (2019)13814824082020Copyright ©; 2019, Eco-VectorCopyright ©; 2019, ООО "Эко-Вектор"2019Eco-VectorООО "Эко-Вектор"https://rjsvd.com/1560-9588/article/view/42950

In recent decades, interest in the role of human papillomavirus (HPV) has been steadily increasing, which can be attributed both to the evolution of molecular genetic detection methods and to the widespread of this viral infection in the population. Epidemiological and molecular biological data suggest that HPV genus beta can cause the development of a number of epithelial non-melanocytic neoplasms of the skin. However, this relationship has not yet been fully studied. Possibly, human papillomavirus infection should be considered from the perspective of co-carcinogenesis with the cumulative effect of UV irradiation, which is indirectly indicated by the predominant localization of elements in open areas of the skin and the high risks of their malignant transformation.

В последние десятилетия интерес к роли вирусов папилломы человека (ВПЧ) неуклонно возрастает, что можно связать как с эволюцией методов молекулярно-генетической детекции, так и с широким распространением этой вирусной инфекции в популяции. Эпидемиологические и молекулярно-биологические данные позволяют предполагать, что ВПЧ рода beta способны вызывать развитие ряда эпителиальных немеланоцитарных новообразований кожи, однако данная взаимосвязь в настоящее время до конца ещё не изучена. Возможно, папилломавирусную инфекцию следует рассматривать с позиций коканцерогенеза с кумулятивным эффектом ультрафиолетового облучения, на что косвенно указывают как преимущественная локализация элементов на открытых участках кожи, так и высокие риски их злокачественного перерождения.

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