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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Skin and Venereal Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Skin and Venereal Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский журнал кожных и венерических болезней</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9588</issn><issn publication-format="electronic">2412-9097</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">375277</article-id><article-id pub-id-type="doi">10.17816/dv375277</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DERMATOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДЕРМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Modern view on rosacea: Topical issues of epidemiology, pathogenesis and therapy. Literature review</article-title><trans-title-group xml:lang="ru"><trans-title>Современный взгляд на розацеа: актуальные вопросы эпидемиологии, патогенеза и терапии. Обзор литературы</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8281-3619</contrib-id><contrib-id contrib-id-type="spin">8080-0721</contrib-id><name-alternatives><name xml:lang="en"><surname>Aleksandrova</surname><given-names>Olga A.</given-names></name><name xml:lang="ru"><surname>Александрова</surname><given-names>Ольга Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant</p></bio><bio xml:lang="ru"><p>ассистент</p></bio><email>olgaalexandrova@live.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-1671-461X</contrib-id><contrib-id contrib-id-type="spin">3577-7335</contrib-id><name-alternatives><name xml:lang="en"><surname>Dubenskiy</surname><given-names>Valeriy  V.</given-names></name><name xml:lang="ru"><surname>Дубенский</surname><given-names>Валерий Викторович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>valerydubensky@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5326-4876</contrib-id><contrib-id contrib-id-type="spin">3332-8424</contrib-id><name-alternatives><name xml:lang="en"><surname>Muraveva</surname><given-names>Ekaterina S.</given-names></name><name xml:lang="ru"><surname>Муравьева</surname><given-names>Екатерина Сергеевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Assistant</p></bio><bio xml:lang="ru"><p>ассистент</p></bio><email>katerisha87@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-4963-3814</contrib-id><name-alternatives><name xml:lang="en"><surname>Tenyaev</surname><given-names>Maksim A.</given-names></name><name xml:lang="ru"><surname>Теняев</surname><given-names>Максим Александрович</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>Student</p></bio><bio xml:lang="ru"><p>студент</p></bio><email>maksonten@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Tver State Medical University</institution></aff><aff><institution xml:lang="ru">Тверской государственный медицинский университет</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-09-08" publication-format="electronic"><day>08</day><month>09</month><year>2023</year></pub-date><volume>26</volume><issue>4</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>363</fpage><lpage>373</lpage><history><date date-type="received" iso-8601-date="2023-05-03"><day>03</day><month>05</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-06-27"><day>27</day><month>06</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Aleksandrova O.A., Dubenskiy V.V., Muraveva E.S., Tenyaev M.A.</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Александрова О.А., Дубенский В.В., Муравьева Е.С., Теняев М.А.</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Aleksandrova O.A., Dubenskiy V.V., Muraveva E.S., Tenyaev M.A.</copyright-holder><copyright-holder xml:lang="ru">Александрова О.А., Дубенский В.В., Муравьева Е.С., Теняев М.А.</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-09-08"/><license><ali:license_ref xmlns:ali="http://www.niso.org/schemas/ali/1.0/">https://creativecommons.org/licenses/by-nc-nd/4.0/</ali:license_ref></license></permissions><self-uri xlink:href="https://rjsvd.com/1560-9588/article/view/375277">https://rjsvd.com/1560-9588/article/view/375277</self-uri><abstract xml:lang="en"><p>Rosacea is a multifactorial dermatological disease that is widespread throughout the world, initially manifested as a cosmetic defect, and in the absence of systemic and topical therapy leads to a change in the structure and functions of the facial skin.</p> <p>Patients with rosacea often seek medical attention, as these aesthetic problems impair their quality of life and contribute to the development of social and psychological problems. Chronic stress is often the cause of the development of social maladaptation, which occurs because of a constant feeling of self-doubt, own inferiority, and anxiety. Anxiety and chronic depression can cause even minor manifestations of rosacea, as it is localized on the skin of the face. Dermatosis often manifests itself in women older than 30 years, under the influence of multiple trigger factors, has a chronic relapsing course.</p> <p>Understanding the pathophysiology and the use of combined therapies can improve the effectiveness of therapy in patients with rosacea, achieve and prolong clinical remission, identify trigger factors and possible prevention. This explains the need to study rosacea not as an independent dermatosis, but as a sign of more significant disorders that can lead not only to social and aesthetic problems, but also affect the general health of the patient.</p></abstract><trans-abstract xml:lang="ru"><p>Розацеа ― распространённое по всему миру мультифакториальное дерматологическое заболевание, которое первоначально проявляется косметологическим дефектом, а при отсутствии системной и наружной терапии приводит к изменению структуры и функций кожи лица.</p> <p>Пациенты с розацеа часто обращаются за врачебной помощью, так как данные эстетические проблемы ухудшают качество их жизни и способствуют развитию социальных и психологических проблем. Хронический стресс часто является причиной развития социальной дезадаптации, который возникает в результате постоянного ощущения неуверенности в себе, собственной неполноценности, тревожности. Тревожное состояние и хроническую депрессию могут вызывать даже незначительные проявления розацеа, так как патологический дефект локализуется на коже лица. Дерматоз чаще проявляется у женщин старше 30 лет под воздействием множественных триггерных факторов, имеет хроническое рецидивирующее течение.</p> <p>Понимание патофизиологии и применение комбинированных методов лечения позволяет повысить эффективность терапии у пациентов с розацеа, достигнуть и продлить клиническую ремиссию, выявить триггерные факторы и возможную профилактику. Это объясняет необходимость изучения розацеа не как самостоятельного дерматоза, а как признак более существенных нарушений, которые могут привести не только к социальным и эстетическим проблемам, но и повлиять на общее здоровье пациента.</p></trans-abstract><kwd-group xml:lang="en"><kwd>rosacea</kwd><kwd>fima</kwd><kwd>etiology</kwd><kwd>pathogenesis</kwd><kwd>classification</kwd><kwd>treatment</kwd><kwd>review</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>розацеа</kwd><kwd>фима</kwd><kwd>этиология</kwd><kwd>патогенез</kwd><kwd>классификация</kwd><kwd>лечение</kwd><kwd>обзор</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Olisova OY, Kochergin NG, Smirnova EA. Innovations in external therapy of rosacea. Russ J Skin Venereal Dis. 2017;20(5):270–274. 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