Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3735110.18821/1560-9588-2018-21-2-113-119Review ArticleINVASIVE METHODS OF TREATMENT OF VITILIGOMelnikovaYulia G.dermatologist, postgraduate student, department of skin and venereal deseases of I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119991, Russian Federationjuli_bond@bk.ruLomonosovK. M-GereykhanovaL. G-First Moscow State Medical University n.a. Sechenov (Sechenov University)1504201821211311921072020Copyright © 2018, Eco-Vector2018The review of the literature is devoted to the use of various invasive treatments for a disease such as vitiligo. The article deals with the majority of methods of treating dermatosis with damage to the integrity of the skin from intraocular administration of corticosteroid preparations, immunomodulators to various methods of “surgical” intervention. Also, examples of techniques of micronidling and nidling with tacrolimus in combination with UVB are given. In addition, some data from one of the potentially effective methods in the treatment of this pathology-the use of platelet-enriched plasma are presented.vitiligomicronidingpuncture transplantationtransplantation of bubble covertransplantation of cultured autologous melanocytestransplantation of hair folliclestransplantation of cultured epidermal graftsa platelet-rich plasmareviewвитилигомикронидлингпункицонная трансплантациятрансплантация покрышек пузырейтрансплантация культивированных аутологичных меланоцитовпересадка волосяных фолликуловпересадка культивированных эпидермальных трансплантатовбогатая тромбоцитами аутоплазмаобзор литературы[Шарафутдинова Л.А., Ломоносов К.М. Современные аспекты топической терапии витилиго. Российский журнал кожных и венерических болезней. 2014; 17(5): 40-5.][Бабешко О.А., Ломоносов К.М., Гилядова Н.М. Роль цитокинов в патогенезе витилиго. Российский журнал кожных и венерических болезней. 2012; 15(3): 37-41.][Сабиров У.Ю., Ибрагимов Ш.И. Хирургические методы лечения витилиго. Клиническая дерматология и венерология. 2013; (1): 84-9.][Reichert-Faria A., Tarle R.G., Dellatorre G., Mira M.T., Silva de Castro C.C. Vitiligo - classification, histopathology and treatment. An Bras. Dermatol. 2014; 89(5): 784-90.][Kandil E. Treatment of localized vitiligo with intradermal injections of triamcinolone acetonide. Dermatologica. 1970; 140(3): 195-206.][Vasistha L.K., Singh G. Vitiligo and intralesional steroids. Indian J. Med. Res. 1979; 69: 308-11.][Chu T.W., AlJasser M., Alharbi A., Abahussein O., McElwee K., Shapiro J. Benefit of different concentrations of intralesional triamcinolone acetonide in alopecia areata: An intrasubject pilot study. J. Am Acad. Dermatol. 2015; 73(2): 338-40.][Nantel-Battista M., Richer V., Marcil I., Benohanian A. Treatment of nail psoriasis with intralesional triamcinolone acetonide using a needle-free jet injector: a prospective trial. J. Cutan. Med. Surg. 2014; 18(1): 38-42.][Ahmad T.J., Rashid T., Rani Z. Needling: An adjunct to narrowband ultraviolet B therapy in localized fixed vitiligo. J. Pakistan Assoc. Dermatol. 2008; 18(3): 149-53. Available at: https://www.researchgate.net/publication/242234408_Needling_An_adjunct_to_narrowband_ultraviolet_B_therapy_in_localized_fixed_vitiligo][Korobko I.V., Lomonosov K.M. A pilot comparative study of topical latanoprost and tacrolimus in combination with narrow-band ultraviolet B phototherapy and microneedling for the treatment of nonsegmental vitiligo. Dermatol. Ther. 2016; 29(6): 437-41. doi: 10.1111/dth.12383.][Falabella R. Surgical approaches for stable vitiligo. Dermatol. Surg. 2005; 31(10): 1277-84.][Feetham H.J., Chan J.L., Pandya A.G. Characterization of clinical response in patients with vitiligo undergoing autologous epidermal punch grafting. Dermatol. Surg. 2012; 38(1): 14-9.][Ko W.C., Chen Y.F. Suction blister epidermal grafts combined with CO2 laser superficial ablation as a good method for treating small-sized vitiligo. Dermatol. Surg. 2009; 35(4): 601-6.][Mohammad T.F., Hamzavi I.H. Surgical therapies for vitiligo. Dermatol. Clin. 2017; 35(2): 193-203.][Ashique K.T., Kaliyadan F. Long-term follow-up and donor site changes evaluation in suction blister epidermal grafting done for stable vitiligo: a retrospective study. Indian. J. Dermatol. 2015; 60(4): 369-72.][Gou D., Currimbhoy S., Pandya A.G. Suction blister grafting for vitiligo: efficacy and clinical predictive factors. Dermatol. Surg. 2015; 41(5): 633-9.][Krishnan A., Kar S. Smashed skin grafting or smash grafting - a novel method of vitiligo surgery. Int. J. Dermatol. 2012; 51(10): 1242-7.][Ghia D., Mulekar S. Handbook of vitiligo: basic science and clinical management. London: JP Medical Publishers; 2015.][Sharma S., Garg V.K., Sarkar R., Relhan V. Comparative study of flip-top transplantation and punch grafting in stable vitiligo. Dermatol. Surg. 2013; 39(9): 1376-84.][Mapar M.A., Safarpour M., Mapar M., Haghighizadeh M.H. A comparative study of the mini-punch grafting and hair follicle transplantation in the treatment of refractory and stable vitiligo. J. Am. Acad. Dermatol. 2014; 70(4): 743-7.][Thakur P., Sacchidanand S., Nataraj H.V., Savitha A.S. A study of hair follicular transplantation as a treatment option for vitiligo. J. Cutan. Aesthet. Surg. 2015; 8(4): 211-7.][Huggins R.H., Henderson M.D., Mulekar S.V., Ozog D.M., Kerr H.A., Jabobsen G., et al. Melanocyte-keratinocyte transplantation procedure in the treatment of vitiligo: the experience of an academic medical center in the United States. J. Am. Acad. Dermatol. 2012; 66(5): 785-93.][Kumar A., Gupta S., Mohanty S., Bhargava B., Airan B. Stem cell niche is partially lost during follicular plucking: a preliminary pilot study. Int. J. Trichology. 2013; 5(2): 97-100.][Vanscheidt W., Hunziker T. Repigmentation by outer-root-sheath-derived melanocytes: proof of concept in vitiligo and leucoderma. Dermatology. 2009; 218(4): 342-3.][Mohanty S., Kumar A., Dhawan J., Sreenivas V., Gupta S. Noncultured extracted hair follicle outer root sheath cell suspension for transplantation in vitiligo. Br. J. Dermatol. 2011; 164(6): 1241-6.][Shah A.N., Marfatia R.K., Saikia S.S. A study of noncultured extracted hair follicle outer root sheath cell suspension for transplantation in vitiligo. Int. J. Trichology. 2016; 8(2): 67-72.][Усовецкий И.А., Бурунова В.В., Короткий Н.Г., Ярыгин К.Н. Консервативная терапия и трансплантация аутологичных меланоцитов при витилиго. Хирург. 2010; 9: 44-51][Yao L., Liu Y., Song Y., Zhong S., Li S. Successful treatment of stable vitiligo by low-density cultured autologous melanocyte transplantation combined with narrowband ultraviolet B therapy. Dermatol. Surg. 2017; 43(10): 1281-7.][Czajkowski R., Placek W., Drewa T., Kowaliszyn B., Sir J., Weiss W. Autologous cultured melanocytes in vitiligo treatment. Dermatol. Surg. 2007; 33(9): 1027-36.][Budania A., Parsad D., Kanwar A.J., Dogra S. Comparison between autologous noncultured epidermal cell suspension and suction blister epidermal grafting in stable vitiligo: a randomized study. Br. J. Dermatol. 2012; 167(6): 1295-301.][Усовецкий И.А., Шарова Н.М., Короткий Н.Г. Клеточная дерматобиология - эффективный инструмент терапии витилиго. Лечебное дело. 2011; 1: 76-9][Abrams G.D., Frank R.M., Fortier L.A., Cole B.J. Platelet-rich plasma for articular cartilage repair. Sports Med. Arthrosc. 2013; 21(4): 213-9.][Kon E., Mandelbaum B., Buda R., Filardo G., Delcogliano M., Timoncini A., et al. Platelet-rich plasma intra-articular injection versus hyaluronic acid viscosupplementation as treatments for cartilage pathology: from early degeneration to osteoarthritis. Arthroscopy. 2011; 27(11): 1490-501.][Зорин В.И., Зорина А.И. PRP в пластической и реконструктивной хирургии. Что нового? Метаморфозы. 2014; 6: 6-20][Ibrahim Z.A., El-Ashmawy A.A., El-Tatawy R.A., Sallam F.A. The effect of platelet-rich plasma on the outcome of short-term narrowband-ultraviolet B phototherapy in the treatment of vitiligo: a pilot study. J. Cosmet. Dermatol. 2016; 15(2): 108-16. doi: 10.1111/jocd.12194.][Yaghoobi R., Omidian M., Bagherani N. Vitiligo: a review of the published work. J. Dermatol. 2011; 38(5): 419-31.][Кубанова А.А., Волнухин В.А., Прошутинская Д.В., Жилова М.Б., Чикин В.В., Карамова А.Э., Сайтбурханов Р.Р. Возможности регенеративной медицины в лечении больных витилиго. Вестник дерматологии и венерологии. 2014; 3: 43-52][Abd El-Samad Z, Shaaban D.Treatment of localized non-segmental vitiligo with intradermal 5-flurouracil injection combined with narrow-band ultraviolet B: a preliminary study. J. Dermatol. Treatm. 2012; 23(6): 443-8.][Mulekar S.V., Isedeh P. Surgical interventions for vitiligo: an evidence-based review. Br. J. Dermatol. 2013; 169 (Suppl. 3): 57-66.]