Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal DiseasesРоссийский журнал кожных и венерических болезней1560-95882412-9097Eco-Vector3725510.18821/1560-9588-2017-20-3-178-183ArticlesСтатьиResearch ArticleHYPERPIGMENTATION OF THE SKIN: MODERN VIEWS ON ETIOLOGY AND PATHOGENESIS (PART 1)ГИПЕРПИГМЕНТАЦИЯ КОЖИ: СОВРЕМЕННЫЕ ВЗГЛЯДЫ НА ЭТИОЛОГИЮ И ПАТОГЕНЕЗ (ЧАСТЬ 1)KruglovaL. SКругловаЛ. СIkonnikovaE. VИконниковаЕвгения Владимировна

assistant, the department of dermatology and cosmetology of Central State Medical Academy of General Management Department of the President of the Russian Federation, Moscow, 121359, Russian Federation

ассистент кафедры дерматовенерологии и косметологии ФГБУ ДПО «Центральная государственная медицинская академия» Управления делами Президента РФ, 121359, г. Москва, Россия

evikonnikova@bk.ruCentral State Medical Academy of General Management Department of the President of the Russian FederationФГБУ ДПО «Центральная государственная медицинская академия» УДП РФ15062017203VOL 20, NO3 (2017)ТОМ 20, №3 (2017)17818321072020Copyright ©; 2017, Eco-VectorCopyright ©; 2017, ООО "Эко-Вектор"2017Eco-VectorООО "Эко-Вектор"https://rjsvd.com/1560-9588/article/view/37255

Brief literature review of the etiology and pathogenesis of hyperpigmentation on the basis of modern scientific publications is presented. The review focuses on actively studied mechanisms of melanin synthesis in norm and pathology, the physiology of pigment cells (melanocytes), their interaction with other structures of the epidermis and dermis and on the mechanisms of regulation of melanogenesis. The main factors influencing the appearance of hyperpigmentation are described.

Представлен краткий литературный обзор этиологии и патогенеза гиперпигментации на основе современных научных публикаций. В обзоре сделан акцент на активно изучающиеся механизмы синтеза меланина в норме и патологии, вопросы физиологии пигментных клеток (меланоцитов), их взаимодействие с другими структурами эпидермиса и дермы, а также на механизмы регуляции меланогенеза. Также освещаются основные факторы, влияющие на возникновение гиперпигментации.

hyperpigmentationmelasmamelanocytemelanogenesismelaninlentiginesгиперпигментациямеланодермиямелазмамеланоцитмеланогенезмеланинлентигоRodriguez-Arambula A., Torres-Alvarez B., Cortes-Garcia D., Fuentes-Ahumada C., Castanedo-Cazares J.P. CD4, IL-17, and COX-2 are associated with subclinical inflammation in malar melasma. Am. J. Dermatopathol. 2015; 37(10): 761-6. doi: 10.1097/DAD.0000000000000378Потекаев Н.Н., Круглова Л.С. Гиперпигментация: причины возникновения и методы коррекции. Клиническая дерматология и венерология. 2012; 10(6): 65-70Lee A.Y. Recent progress in melasma pathogenesis. Pigment Cell Melanoma Res. 2015; 28(6): 648-60. doi: 10.1111/pcmr.12404.Sirimahachaiyakul P., Sood R.F., Muffley L.A., Seaton M., Lin C.T., Qiao L., et al. Race does not predict melanocyte heterogeneous responses to dermal fibroblast-derived mediators. PLoS One. 2015; 10(9): e0139135. doi: 10.1371/journal.pone.0139135.Круглова Л.С., Стенько А.Г., Стрелкович Т.И. Этиология, патогенез, классификация и современные возможности лечения неопухолевых гиперпигментаций кожи. Пластическая хирургия и косметология. 2014; 1: 105-10Duval С., Cohen С., Chagnoleau С., Flouret V., Bourreau E., Slominski F. Key regulatory role of dermal fibroblasts in pigmentation as demonstrated using a reconstructed skin model: impact of photo-aging. PLoS One. 2014; 12(9): e114182.Nguyen B., Tawata S. Mimosine dipeptide enantiomsers: improved inhibitors against melanogenesis and cyclooxygenase. Molecules. 2015; 20(8): 14334-47. doi:10.3390/molecules200814334.Марголина А.А., Петрухина А.О. Современные подходы к отбеливанию кожи. Часть 1 Меланины и кожа. Косметика и медицина. 2001; 1: 4-13.Олисова О. Ю., Андреева Е. В. Еще раз о проблеме гиперпигментации. Российский журнал кожных и венерических болезней. 2014; 17(2): 20-4.Slominski A. Neuroendocrine activity of the melanocyte. Exp. Dermatol. 2009; 18(9): 760-3.Slominski A., Wortsman J. Neuroendocrinology of the skin. Endocrine Rev. 2000; 21(5): 457-87.Chung H., Jung H., Lee J.H., Oh H.Y., Kim O.B., Han I.O., Oh E.S. Keratinocyte-derived laminin-332 protein promotes melanin synthesis via regulation of tyrosine uptake. J. Biol. Chem. 2014; 289(31): 21751-9.Снарская Е.С. Молекулярные исследования в оценке фотостарения и новообразований кожи. Российский журнал кожных и венерических болезней. 2009; 6: 7-9Peng H.Y., Lin C.C., Wang H.Y., Shih Y., Chou S.T. The melanogenesis alteration effects of Achillea millefolium L. essential oil and linalyl acetate: involvement of oxidative stress and the JNK and ERK signaling pathways in melanoma cells. PloS one. 2014; 9(4): e95186.Choi W., Wolber R., Gerwat W., Mann T., Batzer J., Smuda C. The fibroblast-derived paracrine factor neuregulin-1 has a novel role in regulating the constitutive color and melanocyte function in human skin. J. Cell Sci. 2010; 123(18): 3102-11.Adini I., Adini A., Bazinet L., Watnick R.S., Bielenberg D.R., D’Amato R.J. Melanocyte pigmentation inversely correlates with MCP-1 production and angiogenesis-inducing potential. FASEB journal. 2015; 29(2): 662-70.Catania A. The melanocortin system in leukocyte biology. J. Leuk. Biol. 2007; 81(2): 383-92.Zhang Z., Ma J., Yao K., Yin J. Alpha-melanocyte stimulating hormone suppresses the proliferation of human tenon’s capsule fibroblast proliferation induced by transforming growth factor beta1. Mol. Bio.l (Mosk). 2012; 46(4): 628-33.Handel A.C., Miot L.D., Miot H.A. Melasma: a clinical and epidemiological review. An. Bras. Dermatol. 2014; 89(5): 771-82.Hasegawa K., Fujiwara R., Sato K., Park J.Y., Kim S.J., Kim M., et al. Increased blood flow and vasculature in solar lentigo. J. Dermatol. 2016; 43(10): 1209-13.Bak H., Lee H.J., Chang S.E., Choi J.H., Kim M.N., Kim B.J. Increased expression of nerve growth factor receptor and neural endopeptidase in the lesional skin of melasma. Dermatol. Surg. 2009; 35(8): 1244-50. doi: 10.1111/j.1524-4725.2009.01219.x.Kwon S.H., Hwang Y.J., Lee S.K., Park K.C. Heterogeneous pathology of melasma and its clinical implications. Int. J. Mol. Sci. 2016; 17(6): pii E824. doi: 10.3390/ijms17060824.Kim M., Han J.H., Kim J.H., Park T.J., Kang H.Y. Secreted frizzled-related protein 2 (sFRP2) functions as a melanogenic stimulator; the role of sFRP2 in UV-induced hyperpigmentary disorders. J. Invest. Dermatol. 2016; 136(1): 236-44.Hirobe T., Ishikawa A. l-tyrosine induces melanocyte differentiation in novel pink-eyed dilution castaneus mouse mutant showing age-related pigmentation. J. Dermatol. Sci. 2015; 80(3): 203-11.Tamega Ade A., Miot H.A., Moco N.P., Silva M.G., Marques M.E., Miot L.D. Gene and protein expression of oestrogen-β and progesterone receptors in facial melasma and adjacent healthy skin in women. Int. J. Cosmet. Sci. 2015; 37(2): 222-8.Wiedemann C., Nagele U., Schramm G., Berking C. Inhibitory effects of progestogens on the estrogen stimulation of melanocytes in vitro. Contraception. 2009; 80(3): 292-8.Mione M., Bosserhoff A. MicroRNAs in melanocyte and melanoma biology. Pigment Cell Melanoma Res. 2015; 28(3): 340-54.Dai X., Rao C., Li H., Chen Y., Fan L., Geng H., et al. Regulation of pigmentation by microRNAs: MITF-dependent microRNA-211 targets TGF-β receptor 2. Pigment Cell Melanoma Res. 2015; 28(2): 217-22.Nakamura M., Morita A., Seite S., Haarmann-Stemmann T., Grether-Beck S., Krutmann J. Environment-induced lentigines: formation of solar lentigines beyond ultraviolet radiation. Exp. Dermatol. 2015; 24(6): 407-11.Roberts W.E. Pollution as a risk factor for the development of melasma and other skin disorders of facial hyperpigmentation is there a case to be made? J. Drugs Dermatol. 2015; 14(4): 337-41.Rostami Mogaddam M., Iranparvar Alamdari M., Maleki N., Safavi Ardabili N., Abedkouhi S. Evaluation of autoimmune thyroid disease in melasma. J. Cosmet. Dermatol. 2015; 14(2):167-71.Yamaguchi Y., Itami S., Watabe H., Yasumoto K., Abdel-Malek Z.A., Kubo T., et al. Mesenchymal-epithelial interactions in the skin: increased expression of dickkopf1 by palmoplantar fibroblasts inhibits melanocyte growth and differentiation. J. Cell Biol. 2004; 165(2): 275-85.