<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Skin and Venereal Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Skin and Venereal Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский журнал кожных и венерических болезней</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9588</issn><issn publication-format="electronic">2412-9097</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">37130</article-id><article-id pub-id-type="doi">10.18821/1560-9588-2016-19-3-178-183</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Infantile hemangioma: current classification, clinical picture and effective methods of therapy</article-title><trans-title-group xml:lang="ru"><trans-title>Младенческая гемангиома: классификация, клиническая картина и методы коррекции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sheptiy</surname><given-names>Oleg V.</given-names></name><name xml:lang="ru"><surname>Шептий</surname><given-names>Олег Васильевич</given-names></name></name-alternatives><bio xml:lang="en"><p>MD, PhD, Institute of Plastic Surgery and Cosmetology</p></bio><bio xml:lang="ru"><p>кандидат мед. наук, врач-хирург, дерматовенеролог отделения косметологии Института пластической хирургии и косметологии</p></bio><email>shov63@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kruglova</surname><given-names>L. S</given-names></name><name xml:lang="ru"><surname>Круглова</surname><given-names>Л. С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Plastic Surgery and Cosmetology</institution></aff><aff><institution xml:lang="ru">Институт пластической хирургии и косметологии</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Moscow Scientific and Practical Center of Dermatology, Venereology and Cosmetology, Department of Health</institution></aff><aff><institution xml:lang="ru">Московский научно-практический Центр дерматовенерологии и косметологии Департамента здравоохранения г. Москвы</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-06-15" publication-format="electronic"><day>15</day><month>06</month><year>2016</year></pub-date><volume>19</volume><issue>3</issue><issue-title xml:lang="en">VOL 19, NO3 (2016)</issue-title><issue-title xml:lang="ru">ТОМ 19, №3 (2016)</issue-title><fpage>178</fpage><lpage>183</lpage><history><date date-type="received" iso-8601-date="2020-07-21"><day>21</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, ООО "Эко-Вектор"</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-Вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjsvd.com/1560-9588/article/view/37130">https://rjsvd.com/1560-9588/article/view/37130</self-uri><abstract xml:lang="en"><p>Review of the literature devoted to one of the most common tumors of childhood - hemangioma is presented. Literature search was performed using the NCBI, including PubMed, PubMed Health, and The Cochrane Library databases. Infantile hemangioma is a neoplastic proliferation of endothelial cells, which is characterized by different phases of development: proliferation and spontaneous involution. The types of infantile hemangiomas, variants of the course and possible complications such as ulceration, functional disorders, and the formation of cosmetic defects are described. Incidence associated with infantile hemangioma syndrome is presented. The current views on the pathogenesis of infantile hemangiomas are described. Information about the best methods of diagnostic imaging, as well as medical and surgical therapies, including systemic and topical therapy with β-blockers, corticosteroids and use of lasers are described.</p></abstract><trans-abstract xml:lang="ru"><p>Представлен обзор литературы, посвященный одной из наиболее распространенных опухолей детского возраста - гемангиоме. Литературный поиск проводили с использованием NCBI, включающего базы данных PubMed, PubMed Health, The Cochrane Library. Инфантильная (младенческая) гемангиома представляет собой неопластическую пролиферацию эндотелиальных клеток, характеризующихся различными фазами развития: пролиферации, покоя и спонтанной инволюции. В статье описаны типы инфантильной гемангиомы, варианты течения и возможных осложнений, таких как изъязвление, функциональные расстройства, формирование косметических дефектов. Упомянуты частота встречаемости, ассоциированные с инфантильной гемангиомой синдромы. В статье рассмотрены современные взгляды на патогенез инфантильной гемангиомы. Приведены сведения об оптимальных методах диагностической визуализации, а также терапевтических и хирургических методах лечения, включая системную и локальную терапию бета-блокаторами, кортикостероидами, применение лазеров.</p></trans-abstract><kwd-group xml:lang="en"><kwd>infantile hemangioma</kwd><kwd>complications</kwd><kwd>propranolol</kwd><kwd>pulsed dye laser</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>инфантильная гемангиома</kwd><kwd>осложнения</kwd><kwd>пропранолол</kwd><kwd>импульсный лазер на красителях</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bruckner A.L., Frieden I.J. Hemangiomas of infancy. J. Am. Acad. Dermatol. 2003; 48(4): 477-93.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Kilcline C., Frieden I.J. Infantile hemangiomas: how common are they? A systematic review of the medical literature. Pediatr. Dermatol. 2008; 25(2): 168- 73. PMID: 18429772.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Enjolras O., Garzon M.C. Vascular stains, malformations, and tumors. In: Eichenfield L.F., Frieden I.J., Esterly N.B., eds. Neonatal Dermatology. 2nd ed. Philadelphia: Saunders Elsevier; 2008.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Wassef M., Blei F., Adams D., Alomari A., Baselga E., Berenstein A., et al.; ISSVA Board and Scientific Committee. Vascular Anomalies Classification: Recommendations from the International Society for the Study of Vascular Anomalies. Pediatrics. 2015; 136(1): e203--14. doi: 10.1542/peds.2014-3673.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Drolet B.A., Swanson E.A., Frieden I.J.; Hemangioma Investigator Group. Infantile hemangiomas: an emerging health issue linked to an increased rate of low birth weight infants. J. Pediatr. 2008; 153(5): 712-5. doi: 10.1016/j.jpeds.2008.05.043.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Colonna V., Resta L., Napoli A., Bonifazi E. Placental hypoxia and neonatal haemangioma: clinical and histological observations. Br. J. Dermatol. 2010; 162(1): 208-9. doi: 10.1111/j.1365-2133.2009.09493.x.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Folkman J. Proceeding: Tumor angiogenesis factor. Cancer Res. 1974; 34(8): 2109-13.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Barnés C.M., Christison-Lagay E.A., Folkman J. The placenta theory and the origin of infantile hemangioma. Lymphat. Res. Biol. 2007; 5(4): 245-55. doi: 10.1089/lrb.2007.1018.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Hoeger P.H., Maerker J.M., Kienast A.K., Syed S.B., Harper J.I. Neonatal haemangiomatosis associated with placental chorioangiomas: report of three cases and review of the literature. Clin. Exp. Dermatol. 2009; 34(5): e78-80. doi: 10.1111/j.1365-2230.2009.03221.x.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Haggstrom A.N., Lammer E.J., Schneider R.A., Marcucio R., Frieden I.J. Patterns of infantile hemangioma: new clues to hemangioma pathogenesis and embryonic facial development. Pediatrics. 2006; 117(3): 698-703.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Haggstrom A.N., Garzon M.C., Baselga E., Chamlin S.L., Frieden I.J., Holland K., et al. Risk for PHACE syndrome in infants with large facial hemangiomas. Pediatrics. 2010; 126(2): e418-26. doi: 10.1542/peds.2009-3166.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Heyer G.L. PHACE(S) syndrome. Handb. Clin. Neurol. 2015; 132: 169-83. doi: 10.1016/B978-0-444-62702-5.00012-3.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Girard C., Bigorre M., Guillot B., Bessis D. PELVIS syndrome. Arch. Dermatol. 2006; 142(7): 884-8.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Waner M., North P.E., Scherer K.A., Frieden I.J., Waner A., Mihm M.C. Jr. The nonrandom distribution of facial hemangiomas. Arch. Dermatol. 2003; 139(7): 869-75.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Mulliken J.B., Burrows P.E., Fishman S.J., eds. Mulliken and Young’s Vascular Anomalies Hemangiomas and Malformations. 2nd ed. New York: Oxford University Press; 2013.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Chiller K.G., Passaro D., Frieden I.J. Hemangiomas of infancy: Clinical characteristics, morphologic subtypes, and their relationship to race, ethnicity, and sex. Arch. Dermatol. 2002; 138(12): 1567-76.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Frieden I.J., Haggstrom A.N., Drolet B.A., Mancini A.J., Friedlander S.F., Boon L., et al. Infantile hemangiomas: Current knowledge, future directions. Proceedings of a research workshop on infantile hemangiomas, April 7-9, 2005, Bethesda, Maryland, USA. Pediatr. Dermatol. 2005; 22(5): 383-406.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Mulliken J.B., Enjolras O. Congenital hemangiomas and infantile hemangioma: missing links. J. Am. Acad. Dermatol. 2004; 50(6): 875-82.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Chang L.C., Haggstrom A.N., Drolet B.A., Baselga E., Chamlin S.L., Garzon M.C., et al.; Hemangioma Investigator Group. Growth characteristics of infantile hemangiomas: Implications for management. Pediatrics. 2008; 122(2): 360-7. doi: 10.1542/peds.2007-67.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Donnelly L.F., Bissettz G.S. 3rd, Adams D.M. Combined sonographic and fluoroscopic guidance: a modified technique for percutaneous sclerosis of low-flow vascular malformations. Am. J. Roentgenol. 1999; 173(3): 655-7.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Gold L., Nazarian L.N., Johar A.S., Rao V.M. Characterization of maxillofacial soft tissue vascular anomalies by ultrasound and color Doppler imaging: An adjuvant to computed tomography and magnetic resonance imaging. J. Oral. Maxillofac. Surg. 2003; 61(1): 19-31.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Dubois J., Alison M. Vascular anomalies: what a radiologist needs to know. Pediatr. Radiol. 2010; 40(6): 895-905. doi: 10.1007/s00247-010-1621-y.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Bhat V., Salins P.C., Bhat V. Imaging spectrum of hemangioma and vascular malformations of the head and neck in children and adolescents. J. Clin. Imaging Sci. 2014; 4: 31. doi: 10.4103/2156-7514.135179.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Siegel M.J. Magnetic resonance imaging of musculoskeletal soft tissue masses. Radiol. Clin. North Am. 2001; 39(4): 701-20.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Holland K.E., Drolet B.A. Approach to the patient with an infantile hemangioma. Dermatol. Clin. 2013; 31(2): 289-301.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Chen T.S., Eichenfield L.F., Friedlander S.F. Infantile hemangiomas: an update on pathogenesis and therapy. Pediatrics. 2013; 131(1): 99-108.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Haggstrom A.N., Drolet B.A., Baselga E., Chamlin S.L., Garzon M.C., Horii K.A., et al. Prospective study of infantile hamangiomas: clinical characteristics predicting complications and treatment. Pediatrics. 2006; 118(3): 882-7.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Hermans D.J., Boezeman J.B., Van de Kerkhof P.C., Rieu P.N., Van der Vleuten C.J. Differences between ulcerated and non-ulcerated hemangiomas, a retrospective study of 465 cases. Eur. J. Dermatol. 2009; 19(2):152-6. doi: 10.1684/ejd.2008.0576.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Pandey A., Gangopadhyay A.N., Sharma S.P., Kumar V., Gopal S.C., Gupta D.K. Conservative management of ulcerated haemangioma: twenty years’ experience. Int. Wound J. 2009; 6(1): 59-62. doi: 10.1111/j.1742-481X.2008.00562.x.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Luu M., Frieden I.J. Haemangioma: clinical course, complications and management. Br. J. Dermatol. 2013; 169(1): 20-30.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Schwartz S.R., Blei F., Ceisler E., Steele M, Furlan L, Kodsi S. Risk factors for amblyopia in children with capillary hemangiomas of the eyelids and orbit. J. AAPOS. 2006; 10(3): 262-8.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Bramhall R.J., Quaba A. A review of 58 patients with periorbital haemangiomas to determine appropriate cases for intervention. J. Plast. Reconstr. Aesthet. Surg. 2008; 61(2): 138-49.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Rahbar R., Nicollas R., Roger G., Triglia J.M., Garabedian E.N., McGill T.J., Healy G.B. The biology and management of subglottic hemangioma: past, present, future. Laryngoscope. 2004; 114(11): 1880-91.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Orlow S.J., Isakoff M.S., Blei F. Increased risk of symptomatic hemangiomas of the airway in association with cutaneous hemangiomas in a “beard” distribution. J. Pediatr. 1997; 131(4): 643-6.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Hoger P.H., Harper J. Kinderdermatologie: Differenzialdiagnostik und Therapie bei Kindern und Jugendlichen. Stuttgart: Schattauer; 2011.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Leaute-Labreze C., Dumas de la Roque E., Hubiche T., Boralevi F., Thambo J.B., Taieb A. Propranolol for severe hemangiomas of infancy. N. Engl. J. Med. 2008; 358(24): 2649-51. doi: 10.1056/NEJMc0708819.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Sans V., de la Roque E.D., Berge J., Grenier N., Boralevi F., Mazereeuw-Hautier J., et al. Propranolol for severe infantile hemangiomas: follow-up report. Pediatrics. 2009; 124(3): e423-31. doi: 10.1542/peds.2008-3458.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Hogeling M., Adams S., Wargon O. A randomized controlled trial of propranolol for infantile hemangiomas. Pediatrics. 2011; 128(2): e259-66.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Georgountzou A., Karavitakis E., Klimentopoulou A., Xaidara A., Kakourou T. Propranolol treatment for severe infantile hemangiomas: a single-centre 3-year experience. Acta Paediatr. 2012; 101(10): e469-74. doi:10.1111/j.1651-2227.2012.02783.x.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Chim H., Armijo B.S., Miller E., Gliniak C., Serret M.A., Gosain A.K. Propranolol induces regression of hemangioma cells through HIF-1α-mediated inhibition of VEGF-A. Ann. Surg. 2012; 256(1): 146-56. doi:10.1097/SLA.0b013e318254ce7a.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Storch C.H., Hoeger P.H. Propranolol for infantile haemangiomas: insights into the molecular mechanisms of action. Br. J. Dermatol. 2010; 163(2): 269-74.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Drolet B.A., Frommelt P.C., Chamlin S.L., Haggstrom A., Bauman N.M., Chiu Y.E., et al. Initiation and use of propranolol for infantile hemangioma: report of a consensus conference. Pediatrics. 2013; 131(1): 128-40. doi: 10.1542/peds.2012-1691.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Marqueling A.L., Oza V., Frieden I.J., Puttgen K.B. Propranolol and infantile hemangiomas four years later: a systemic review. Pediatr. Dermatol. 2013; 30(2): 182-91.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Admani S., Feldstein S., Gonzalez E.M., Friedlander S.F. Beta blockers: an innovation in the treatment of infantile hemangiomas. J. Clin. Aesthet. Dermatol. 2014; 7(7): 37-45.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Bagazgoitia L., Torrelo A., Gutierrez J.C., Hernandez-Martin A., Luna P., Gutierrez M., et al. Propranolol for infantile hemangiomas. Pediatr. Dermatol. 2011; 28(2): 108-14.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Sondhi V., Patnaik S.K. Propranolol for Infantile Hemangioma (PINCH): an open-label trial to assess the efficacy of propranolol for treating infantile hemangiomas and for determining the decline in heart rate to predict response to propranolol. J. Pediatr. Hematol. Oncol. 2013; 35(7): 493-9.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Bagazgoitia L., Hernandez-Martin A., Torrelo A. Recurrence of infantile hemangiomas treated with propranolol. Pediatr. Dermatol. 2011; 28(6): 658-62.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Ni N., Langer P., Wagner R., Guo S. Topical timolol for periocular hemangioma: report of further study. Arch. Ophthalmol. 2011; 129(3): 373-9. doi: 10.1001/archophthalmol.2011.24.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Thomas J., Kumar P., Kumar D.D. Ulcerated infantile haemangioma of buttock successfully treated with topical timolol. J. Cutan. Aesthet. Surg. 2013; 6(3): 168-9. doi: 10.4103/0974-2077.118432.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Chakkittakandiyil A., Phillips R., Frieden I.J., Siegfried E., Lara-Corrales I., Lam J., et al. Timolol maleate 0.5% or 0.1% gel-forming solution for infantile hemangiomas: a retrospective, multicenter, cohort study. Pediatr. Dermatol. 2012; 29(1): 28-31. doi: 10.1111/j.1525-1470.2011.01664.x.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Semkova K., Kazandjieva J. Topical timolol maleate for treatment of infantile haemangiomas: preliminary results of a prospective study. Clin. Exper. Dermatol. 2013; 38(2): 143-6.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Greene A.K., Couto R.A. Oral prednisolone for infantile hemangioma: efficacy and safety using a standardized treatment protocol. Plast. Reconstr. Surg. 2011; 128(3): 743-52.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Jalil S., Akhtar J., Ahmed S. Corticosteroids therapy in the management of infantile cutaneous hemangiomas. J. Coll. Physicians Surg. Pak. 2006; 16(10): 662-5.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Witman P.M., Wagner A.M., Scherer K., Waner M., Frieden I.J. Complications following pulse dye laser treatment of superficial hemangiomas. Lasers Surg. Med. 2006; 38(2): 116-23.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>David L.R., Malet M.M., Argenta L.C. Efficacy of pulse dye laser therapy for the treatment of ulceratd haemagiomas: a review of 78 patients. Br. J. Plast. Surg. 2003; 56(4): 317-27.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Di Maio L., Baldi A., Dimaio V., Barzi A. Use of flashlamp-pumped pulsed dye laser in the treatment of superficial vascular malformations and ulcerated hemangiomas. In Vivo. 2011; 25(1): 117-23.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Admani S., Krakowski A.C., Nelson J.S., Eichenfield L.F., Friedlander S.F. Beneficial effects of early pulsed dye laser therapy in individuals with infantile hemangiomas. Dermatol. Surg. 2012; 38(10): 1732-8. doi: 10.1111/j.1524-4725.2012.02487.x.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Asilian A., Mokhtari F., Kamali A.S., Abtahi-Naeini B., Nilforoushzadeh M.A., Mostafaie S. Pulsed dye laser and topical timolol gel versus pulse dye laser in treatment of infantile hemangioma: A double-blind randomized controlled trial. Adv. Biomed. Res. 2015; 4: 257. doi: 10.4103/2277-9175.170682.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Vlachakis I., Gardikis S., Michailoudi E., Charissis G. Treatment of hemangiomas in children using a Nd:YAG laser in conjunction with ice cooling of the epidermis: techniques and results. BMC Pediatr. 2003; 3: 2.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Waldschmidt J., Giest H., Meyer L. Endoscopic laser application in 56 children with hemangiomas of the larynx and trachea. Med. Laser Appl. 2005; 20(4): 297-302.</mixed-citation></ref></ref-list></back></article>
