Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3712510.18821/1560-95882016-19-3-173-177Research ArticleMelanocortin 1 receptor MC1R as a genetic factor in the development of psoriasisGalimovaElvira S.Institute of Biomedicine and Translational Medicine; BD, PhD, Research Fellow, Laboratory of Human Molecular Genetics Institute of Biochemistry and Genetics of Ufa Scientific Center of Russian Academy of Scienceselya-4@yandex.ruKõksSulevInstitute of Biomedicine and Translational Medicine-KingoKülliDepartment of dermatology, University of Tartu-KhusnutdinovaE. K-Institute of Biochemistry and Genetics of Ufa Scientific Center of Russian Academy of SciencesTranslational Medicine1506201619317317721072020Copyright © 2016, Eco-Vector2016The CRH-POMC system in the skin coordinates pigmentation and the immune response. We performed the association study of single-nucleotide polymorphism SNPs of MC1R gene in a cohort ofpsoriasis patients of Tatar ethnic group from the Volga-Ural region of Russia. The results suggest that polymorphisms of the MC1R gene may contribute to the protection or development of psoriasis in Tatar population.psoriasisMC1R genesingle-nucleotide polymorphismпсориазген MC1Rоднонуклеотидный полиморфизм[Slominski A., Wortsman J., Pisarchik A., Zbytek B., Linton E.A., Mazurkiewicz J.E., et al. Cutaneous expression of corticotropinreleasing hormone (CRH), urocortin, and CRH receptors. FASEB J. 2001; 15(10): 1678-93.][Slominski A., Wortsman J., Luger T., Paus R., Solomon S. Corticotropin releasing hormone and proopiomelanocortin involvement in the cutaneous response to stress. Physiol. Rev. 2000; 80(3): 979-1020.][Gantz I., Fong T.M. The melanocortin system. Am. J. Physiol. Endocrinol. Metab. 2003; 284(3): E468-74.][Wikberg J.E.S. 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