Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3711410.18821/1560-9588-2016-19-3-167-169Research ArticleVitiligo treatment algorithmLomonosovKonstantin M.MD, PhD, DSc, prof. Department of skin venereal diseases of medical faculty I.M. Sechenov First Moscow State Medical Universitylamdinic@yandex.ruGereykhanovaL. G-I.M. Sechenov First Moscow State Medical University1506201619316716921072020Copyright © 2016, Eco-Vector2016The treatment strategy ofpatients with vitiligo, including the identification of motivation for long-term treatment and informing patients to avoid false expectations as causes of dissatisfaction and early termination of the therapeutic course are described. The algorithm for the treatment of vitiligo consists of five successive stages. Each of them is sequentially applied with no previous treatment regimens efficiency or its maximum possible effect achievement. The use of the described treatment algorithm allows us to achieve in 70-80% of cases a marked repigmentation of vitiligo and to ensure long-term and often life-long remission of the disease.vitiligotreatmentneovirtopical medicationphototherapyexcimer laserozone therapyвитилиголечениенеовиртопические препаратыфототерапияэксимерный лазерозонотерапия[Picardo M., Dell’Anna M.L., Ezzedine K., Hamzavi I., Harris J.E., Parsad D., Taieb A. Vitiligo. Nat. Rev. Dis. Primers. 2015; 1: 15046. doi: 10.1038/nrdp.2015.46. http://go.nature.com/vIhFSC.][Ezzedine K., Lim H.W., Suzuki T., Katayama I., Hamzavi I., Lan C.C., et al.; Vitiligo Global Issue Consensus Conference Panelists. Revised classification/nomenclature of vitiligo and related issues: the Vitiligo Global Issues Consensus Conference. Pigment. Cell Melanoma Res. 2012; 25(3): E1-13. doi: 10.1111/j.1755-148X.2012.00997.x.][Бабешко О.А. Патогенетическое обоснование комплексной дифференцированной терапии витилиго. Available at: http://www.dslib.net/bolezni-kozhi/patogeneticheskoe-obosnovaniekompleksnoj-differencirovannoj-terapii-vitiligo.html (последний доступ 10.03.2016).][Герейханова Л.Г., Ломоносов К.М, Башлакова К.А. Окислительный стресс в патогенезе витилиго и методы его коррекции. Российский журнал кожных и венерических болезней. 2016; 19(1): 45-8.][Hann S.K., Gauthier Y., Benzekri L. Generalized vitiligo. In: Picardo M., Taieb A., eds. Vitiligo. Springer; 2010. Ch.1.3.2: 41-9.][Sapam R., Agrawal S., Dhali T.K. Systemic PUVA vs narrowband UVB in the treatment of vitiligo: a randomized controlled study. Int. J. Dermatol. 2012; 51(9): 1107-15. doi: 10.1111/j.1365-4632.2011.05454.x.][Lim H.W., Grimes P.E., Agbai O., Hamzavi I., Henderson M., Haddican M., et al. Afamelanotide and narrowband UVB phototherapy for the treatment of vitiligo: a randomized multicenter trial. JAMA Dermatol. 2015; 151(1): 42-50. doi: 10.1001/jamadermatol.2014.1875.][Dong D., Jianq M., Xu X., Guan M., Wu J., Chen Q., Xiang L. The effects of NB-UVB on the hair follicle-derived neural crest stem cells differentiating into melanocyte lineage in vitro. J. Dermatol. Sci. 2012; 66(1): 20-8. doi: 10.1016/j.jdermsci.2012.01.012.][Gawkrodger D.J., Ormerod A.D., Shaw L., Mauri-Sole I., Whitton M.E., Watts M.J., et al.; Therapy Guidelines and Audit Subcommittee, British Association of Dermatologists; Clinical Standards Department, Royal College of Physicians of London; Cochrane Skin Group; Vitiligo Society. Guideline for the diagnosis and management of vitiligo. Br. J. Dermatol. 2008; 159(5): 1051-76. doi: 10.1111/j.1365-2133.2008.08881.x.]