Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3700510.17816/dv37005Research ArticleDiffuse alopecia and a method for its complex correctionSnarskayaE. SDepartment of Cutaneous and Sexually-Transmitted Diseases, Therapeutic Facultysnarskaya-dok@mail.ruGrishinaValeriya B.Department of Cutaneous and Sexually-Transmitted Diseases, Therapeutic Faculty; postgraduatedzhavaha@mail.ruI.M. Setchenov First Moscow State Medical University15082015184495521072020Copyright © 2015, Eco-Vector2015A specific feature of hair growth in humans is the highest concentration of hair follicles in the skin of the head. Complaints of hair loss and poor hair growth are most often responsible for patient’s application to the doctor. Alopecia is pathological hair falling, leading to their partial or complete loss in certain areas of the head or trunk. Diffuse alopecia is characterized by manifest even hair falling from the hairy part of the head in men and women as a result of hair cycle failure. The molecular mechanisms regulating the hair follicle growth and the follicle transition from one phase into another are now known. A unique complex system for hair loss control is suggested. Selencin combines the therapeutic effects of a homeopathic drug and a specialized cosmetic program. Experience gained in effective use of Selencin program is presented in this paper.hair physiologyalopeciatherapy for diffuse alopeciaSelencinфизиология волосалопециялечение диффузной алопецииСеленцин[Иванова О.Е., Лопатин В.В., Нечаева И.В., Чельцова Л.К. Русский орфографический словарь. М.: Институт русского языка им. В.В. Виноградова Российской академии наук; 2004.][Аравийская Е.Р., Михеев Г.Н., Мошкалова И.А., Соколовский Е.В. Облысение. Дифференциальный диагноз. Методы терапии. СПб.: СОТИС; 2003.][Habif T.P. Clinical dermatology: a color guide to diagnosis and therapy. Elsevier Health Sciences; 2009.][Горячкина В.Л., Иванова М.Ю., Цомартова Д.А., Карташкина Н.Л., Кузнецов С.Л., Ломоносов К.М., Заборова В.А. Физиология волосяных фолликулов. Российский журнал журнал кожных и венерических болезней. 2015; 3: 51-4.][Tobin D.J. The biogenesis and growth of human hair. In: Tobin D.J., ed. Hair in Toxicology - an important biomonitor. Cambridge: The Royal Society of Chemistry; 2005: 3-33.][Bernard B.A. The human hair follicle, a bistable organ? Exper. Dermatol. 2012; 21(6): 401-3.][Randall V.A., Botchkareva N.V. The biology of hair growth. In: Gurpreet S. A., ed. Cosmetics applications of laser and light-based systems. William Andrew; 2009: 3-5.][Ноздрин В.И., Горпинич И.В. Смена волос. Альманах Ретиноиды. Вып. 27. М.; 2008: 35-53.][Nakatake Y., Hoshikawa M., Asaki T., Kassai Y, Itoh N. Identification of novel fibroblast growth factor, FGF 22, preferentially expressed in the inner root sheath of hair follicle. Biochem. Biophys. Acta. 2001; 1517(3): 460-3.][Bayer-Garner J., Sanderson R., Smoller B. Syndican-1 is strongly expressed in the anagen hair follicle outer root sheath and in the dermal papilla but expression diminishes with involution of the hair follicle. Am. J. Dermatopathol. 2002; 24(6): 484-9.][Hibino T., Nishiyama T. Role of TGF-β2 in the human hair cycle. J. Dermatol. Sci. 2004; 35(1): 9-18.][Dawber R., Van Neste D. Hair and scalp disorders - common presenting signs, differential diagnosis and treatment. London: Lippincott Williams Wilkins; 1995.][Peters E.M., Hansen M.G., Overall R.W., Nakamura M., Pertile P., Klapp B.F., et al. Control of human hair growth by neurotrophins: brain-derived neurotrophic factor inhibits hair shaft elongation, induces catagen, and stimulates follicular transforming growth factor beta2 expression. J. Invest. Dermatol. 2005; 124(4): 675-85.][Абрукова А.В. Эпидемиологическое и клинико-генетическое исследование наследственного гипотрихоза в Республике Чувашия: Автореф. дис. ... канд. мед. наук. М.; 2007.][http://selencin.ru/alopecia/][Фицпатрик Т., Джонсон Р., Вульф К., Полано М., Сюрмонд Д. Дерматология. Атлас-справочник. Пер. с англ. М.: Практика; 1999: 18-36.][http://selencin.ru/active_ingredients/]