Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3697510.17816/dv36975Research ArticleClinical efficiency of Zineryt lotion and its effect on the quality of life of adolescents with mild and medium severe acneKorotkyNikolay G.MD, PhD, DSc, prof.derma@rdkb.ruZaslavskyD. V-YutskovskyA. DVladivostok, the Russian Federation-TikhomirovA. Aderma@rdkb.ruAndreenkoO. Nderma@rdkb.ruLazutinaE. Vderma@rdkb.ruGamayunovB. N-TulenkovaE. S-N.I. Pirogov Russian National Research Medical UniversityRussian Pediatric Clinical HospitalSt. Petersburg State Pediatric Medical UniversityPacific State Medical University15022015181586121072020Copyright © 2015, Eco-Vector2015Modern literature on the pathogenesis of acne is reviewed. The role of Propionbacterium acnes in stimulation and maintenance of immunological mechanisms of disease emergence and maintenance is emphasized. The effects of acne on the mental status and quality of life of patients of different age were studied. The effects of acne and Zineryt lotion therapy on the mental status and the relevant quality of life of the youngest and most vulnerable patients were evaluated within the framework of a SPOTLESS multicenter prospective observation program, aimed at evaluating the clinical efficiency of Zinerit lotion and its effects on the quality of life of adolescents with mild and medium severe acne. The treatment efficiency was evaluated by the time course of inflammation elements and by the effects of acne and therapy on the patients ’ quality of life.Propionbacterium acnesacneacne vulgarisPropionbacterium acnesZinerytquality of lifeакневульгарные угрилосьон Зинериткачество жизни[Thiboutot D., Gollnick H., Bettoli V., Dreno B., Kang S., Leyden J.J., et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne group. J. Am. Acad. Dermatol. 2009; 60(5, Suppl): S1-50.][Jeremy A.H., Holland D.B., Roberts S.G., Thomson K.F., Cunliffe W. J. Inflammatory events are involved in acne lesion initiation. J. Invest. Dermatol. 2003; 121(1): 20-7. http://reference.medscape.com/medline/abstract/12839559][Kim J., Ochoa M.T., Krutzik S.R., Takeuchi O., Uematsu S., Legaspi A.J., et al. Activation of toll-like receptor 2 in acne triggers inflammatory cytokine responses. J. Immunol. 2002; 169(3): 1535-41.][Webster G.F. Inflammatory acne represents hypersensitivity to Propionibacterium acnes. Dermatology. 1998; 196(1): 80-1.][Lucky A.W., Biro F.M., Simbartl L.A., Morrison J.A., Sorg N.W. Predictors of severity of acne vulgaris in young adolescent girls: results of a five-year longitudinal study. J. Pediatr. 1997; 130(1): 30-9.][Zouboulis C.C., Bohm M. Neuroendocrine regulation of sebocytes - a pathogenetic link between stress and acne. Exp. Dermatol. 2004;13(Suppl. 4): 31-5.][Инструкция по медицинскому применению препарата Зинерит П № 013569/01-110309. http://grls.rosminzdrav.ru][Белькова Ю.А., Петрунин Д.Д. О местном применении антибактериальных препаратов в терапии акне. Вестник дерматологии и венерологии. 2010; 3: 75-85.][Хлебникова А.Н., Петрунин Д.Д. Цинк, его биологическая роль и применение в дерматологии. Вестник дерматологии и венерологии. 2013; 6: 100-16.]