The register of patients with basal-cell cutaneous carcinoma (BCCC) in Regional Center of Skin and Sexually-Transmitted diseases No. 3 in Chelyabinsk, was created with consideration for the professional appurtenance of 267 patients living in the industrial region of the city (in the town of Kopeisk). The patients were distributed into 5 professional groups: 56 patients engaged in coal mining, 18 in metallurgy, 92 workers without harmful occupational exposure, and 58 patients not engaged in industry. Multiple BCCC was more often diagnosed in patients from professional groups exposed to harmful factors (21.9, 27, and 27.8%); primary multiple cancer was diagnosed in 14.6% of patients engaged in coal mining and 16.2% of patients engaged in chemical industry. Multidimensional factorial analysis showed that occupational factors were the leading risk factors for BCCC in professional groups with harmful occupational exposure, while the risk factors for other professional groups were insolation and patient’s skin phototype.