Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3689810.17816/dv36898Research ArticleUnilateral dermatoses: Relationship with Blashko's lines and neurological changesOlisovaOlga Yu.MD, PhD, DSc, prof.olisovaolga@mail.ruGrabovskayaO. Volgadoctor@mail.ruTeplyukN. PTeplyukn@gmail.comBelousovaT. Abelka-1147@mail.ruVarshavskyV. Avavarsh@mma.ruArsentyevN. Skolendra@mail.ruShpitalnikovaN. Gshpitalnikova@mail.ruDzhavakhishviliI. Sirusa-irusa@yandex.ruPyatilovaP. Mpypolina@mail.ruI.M. Setchenov First Moscow Medical University15102014175222921072020Copyright © 2014, Eco-Vector2014Blashko’s lines correspond to the mutant cell migration and proliferation routes during embryogenesis. Unilateral dermatoses (UD), congenital and acquired ones, are located along Blashko’s lines. The term UD is more often used in Russian publications. Segmented, linear, blashkoid, or Blashko line dermatoses are the terms used by foreign specialists. The skin mosaicism theory is now confirmed at the cell level for at least 15 dermatoses, including nevoid andX-linked dermatoses. However, the pathogenetic mechanism of unilateral location inacquired UD remains unclear. Monolateral involvement may be observed in type I segmented mosaicism in autosomal dominant diseases. On the other hand, some authors explain the unilateral location of these dermatoses by involvement of the central and peripheral nervous system.unilateral dermatosismosaicismBlashko’s linesneurological changesунилатеральный дерматозмозаицизмлинии Блашконеврологические изменения[Happle R., Mittag H., Kuster W. The CHILD nevus: a distinct skin disorder. Dermatology. 1995; 191(3): 210-6.][Happle R. Dohi Memorial Lecture. New aspects of cutaneous mosaicism. J. Dermatol. 2002; 29(11): 681-92.][Chemke J., Rappaport S., Etrog R. Aberrant melanoblast migration associated with trisomy 18 mosaicism. J. Med. Genet. 1983; 20(2): 135-7.][Siegel D.H., Sybert V.P. 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