Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3688910.17816/dv36889Research ArticleStudies of lichen planus pathomorphosis by evaluating its modern histological signsBarbinovV. Vvvb07@rambler.ruChirskyV. Sv_chirsky@mail.ruTarasenkoG. Ndrtarasenko@yandex.ruBarbinovD. Vdenisbarbinoff@yandex.ruS.M. Kirov Military Medical AcademyA.A. Vishnevsky Central Military Clinical HospitalDr. Voit Clinic15062014173424821072020Copyright © 2014, Eco-Vector2014Statistically significant histological models of lichen planus (LP) were detected by comparing histological preparations from 102 patients with the final diagnosis of LP, analyzed using a Histoderm expert system, with the final clinical diagnosis in this sample, after preliminary analysis (by the same expert system) of more than 600 histological symptoms vs. 224 other dermatoses presented in this system. Comparison of the results of two studies showed that of the symptoms determining various dermatoses, 49 were statistically significant for the diagnosis of LP, corresponding to its 6 histological models. Only 22 symptoms, characterizing only 2 of the probable histological models, were significant in skin biopsy specimens from our sample ofpatients with LP. The results indicated the LP pathomorphosis and indirectly confirmed the immunoallergic hypothesis of its pathogenesis.lichen planushistological models of inflammatory dermatosesexpert systemsHistodermкрасный плоский лишайгистологические модели воспалительных дерматозовэкспертные системы"Гистодерм"[Довжанский С.И., Слесаренко Н.А. Красный плоский лишай. Саратов: Изд-во Саратов. ун-та; 1990.][Sugerman P.B., Savage N.W., Walsh L.J., Zhao Z.Z., Zhou X.J., Khan A., et al. The pathogenesis of oral lichen planus. Crit. Rev. Oral. Biol. Med. 2002; 13(4): 350-5.][Korn T., Bettelli E., Oukka M., Kuchroo V.K. IL-17 and Th17 cells. Annu. Rev. Immunol. 2009; 27: 485-517. doi: 10.1146/annurev.immunol.021908.132710.][Ackerman А.В. Histologic diagnosis of inflammatory skin diseases: a method by pattern analysis. Philadelphia: Lea Febiger; 1978.][Pinkus H., Mehregan A.H. A guide to dermatohistopathology. New York: Appleton-Century Crofts; 1981.][Lever W.F., Schaumburg-Lever J. Histopathology of the skin. 6th ed. Toronto: Lippincott; 1983.][Elder E.E., Elenitsas R., Johnson B.L., Murphy G.F., Xu X. Lever’s histopathology of the skin. 10th ed. Philadelphia: Wolters Kluwer; Lippincott Williams Wilkins; 2009.][Rodionov A.N., Samtsov A.V., Barbinov V.V., Akhmedov I.G. Expert system in dermatopathology. J. Eur. Acad. Dermatol. Venerol. 1995; 5(Suppl. 1): 139.][Барбинов В.В. Экспертные системы в дерматогистопатологии (инженерия знаний в компьютерных технологиях преподавания и диагностики): Автореф. дис.. д-ра мед. наук. СПб., 1998.][Самцов А.В., Барбинов В.В., Решетник Д.А., Минулин И.К., Богданов Г.В., Кавокин М.К. Организация гистологической диагностики дерматозов с использованием видеоинформа-ционных технологий. Вестник дерматологии и венерологии. 2012; 6: 11-9.]