Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector3686310.17816/dv36863Research ArticleCONSERVATIVE THERAPY OF PATIENTS WITH CICATRICIAL CHANGES IN THE SKIN BY ELECTRODE PHARMAPHORESISStenkoA. Gstenko1@rambler.ruShchukinaE. V-ShmatovaA. Aanastasia988@mail.ruShugininaO. Iolga-shuginina@yandex.ruZhukovaO. Vklinderma@list.ruTechievaS. GTetchieva@hotmail.comBeauty Institute on the Arbat Street: Active Longevity ClinicMoscow Research and Practical Center of Dermato-Venereology and Cosmetology15022014171586121072020Copyright © 2014, Eco-Vector2014Clinical efficiency of transdermal administration of proteolytic enzyme complex in the treatment of keloid scars is evaluated. The mechanisms of transdermal administration of drugs, the advantages of the method, the technique of the procedure, clinical results, and ultrasonic scanning are described.keloid and hypertrophic cicatricesconservative treatmenelectrode pharmaphoresisкелоидные и гипертрофические рубцыконсервативное лечениеэлектродный фармафорез[Озерская О.С. Рубцы кожи. Экспериментальная и клиническая дерматокосметология. 2004; 4: 50—7][Darzi M.A., Chowdri N.A., Kaul S.K., Khan M. Evaluation of various methods of treating keloids and hypeitiophic scars: a 10-year follow-up study. Br. J. Plast. Surg. 1992; 45(5): 374.][Mustoe T.A., Cooter R.D., Gold M.N. International clinical recommendations on scar management. Plast. Reconstr. Surg. 2002; 110(6): 560—71.][Grossman K.L. Facial scars. Clin. Plast. Surg. 2000; 27(4): 627—42.][Климова О.А., Чеботарев В.Ю. Коллагенолитический комплекс протеаз из гепатопанкреаса камчатского краба: разделение на индивидуальные компоненты. Бюллетень экспериментальной биологии и медицины. 1999; 9: 308—13][Misefari M., D’Africa A., Sartori M., Morabido F. Transdermal transport by hydroelectrophoresis: a novel method for delivering molecules. J. Biol. Regul. Homeost. Agents. 2001; 15(4): 381—2.][Peled Z.M., Chin G.S., Liu W.L. Response to tissue injury nonoperative techiques in facial rejuvenation. Pt. I. Clin. Plast. Surg. 2000; 27(4): 489—500.][Pliquett U.F. Nonlinearity of molecular transport trough human skin due to electrical stimulus. J. Contr. Release. 2006; 68(3): 373—86.][Martin V.S., Albanesi J.P. Membrane fusion stalk model revisited. J. Biophys. 2002; 82(2): 693—712.][Kuzmin P.I., Zimmerberg J., Chizmadzhev Y.A., Cohen F.S. A quantitative model for membrane fusion based on low-energy intermediates. Proc. Natl. Acad. Sci. U.S.A. 2001; 98(13): 7235—40.]