Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal DiseasesРоссийский журнал кожных и венерических болезней1560-95882412-9097Eco-Vector3677110.17816/dv36771ArticlesСтатьиResearch ArticlePLATELET-RICH PLASMA IN THE TREATMENT OF CHRONIC SKIN WOUNDSСовременные методы лечения длительно незаживающих ран кожиProsyannikovaN. VПросянниковаН. В.

врач

tynrik@yandex.ruLipovaE. VЛиповаЕ. В.

д-р мед. наук, проф.

PokrovskyK. AПокровскийК. А.

д-р мед. наук, проф.

TarasenkoG. NТарасенкоГ. Н.

канд. мед. наук, доцент

drtarasenko@yandex.ruФГБУ Поликлиника №1 Управления делами Президента Россиигородская клиническая больница № 67 им. Л.А. ВорохобоваФГКУ 3-й Центральный военный клинический госпиталь им. А. А. Вишневского Минобороны России15122012156NO6 (2012)№6 (2012)475121072020Copyright ©; 2012, Eco-VectorCopyright ©; 2012, ООО "Эко-Вектор"2012Eco-VectorООО "Эко-Вектор"https://rjsvd.com/1560-9588/article/view/36771

The problem of treatment of chronic wounds of the skin is discussed. A new method is described: platelet-rich plasma, methods for its preparation and use. Meta-analysis offoreign publications on the efficiency of this method is offered.

Освещена проблема лечения длительно незаживающих ран кожи. Описаны новая современная методика лечения — богатая тромбоцитам плазма, способы изготовления и применения, а также проведен метаанализ данных зарубежной литературы, касающихся эффективности использования этого метода.

chronic skin wounds and ulcersautologous and heterologous platelet-rich plasmaplatelet growth factorsдлительно незаживающие раны и язвы кожиаутологичная и гетерологичная богатая тромбоцитами плазмабогатая тромбоцитам плазмафакторы роста тромбоцитовАхмеров Р.Р., Зарудий Р.Ф. Применение обогащенной тромбоцитами аутоплазмы для лечения фотодерматоза. Регенеративная хирургия. 2005; 3: 2—5.Anitua E, Sánchez M, Prado R., Orive G. Plasma rich in growth factors: the pioneering autologous technology for tissue regeneration. J. Biomed. Mater. Res. A. 2011; 97(4): 536. doi: 10.1002/ jbm.a.33053.Soomekh D.J. Current concepts for the use of platelet-rich plasma in the foot and ankle. Clin. Podiatr. Med. Surg. 2011; 28(1): 155—70.Bennett N.T., Schultz G.S. Growth factors and wound healing: Part II. Role in normal and chronic wound healing. Am. J. Surg. 1993; 166(1): 74—81.Frykberg R.G., Driver V.R., Carman D., Lucero B., Borris-Hale C., Fylling C.P. et al. Chronic wounds treated with a physiologically relevant concentration of platelet-rich plasma gel: a prospective case series. Ostomy Wound Manage. 2010; 56(6): 36—44.Sánchez A.R., Eckert S.E., Sheridan P.J., Weaver A.L. Influence of platelet-rich plasma added to xenogeneic bone grafts on tone mineral density associated with dental implants. Int. J. Oral. Maxillofac. Implants. 2005; 20(4): 526—32.El-Sharkawy H., Kantarci A., Deady J., Hasturk H., Liu H., Alshahat M., Van Dyke T.E. Platelet-rich plasma: growth factors and pro- and anti-inflammatory properties. J. Periodontol. 2007; 78(4): 661—9.Fernández-Barbero J.E., Galindo-Moreno P., Avila-Ortiz G., Caba O., Sánchez-Fernández E., Wang H.L. Flow cytometric and morphological characterization of platelet-rich plasma gel. Clin. Oral Implants Res. 2006; 17(6): 687—93.Petrungaro P.S. Using platelet-rich plasma to accelerate soft tissue maturation in esthetic periodontal surgery. Compend. Contin. Educ. Dent. 2001; 22(9): 729—32.Yoo J., Roth K., Hughes B., Fung K., Franklin J., Lampe H., Pietrzak W.S. Evaluation of postoperative drainage with application of platelet-rich and platelet-poor plasma following hemithyroidectomy: a randomized controlled clinical trial. Head Neck. 2008; 30(12): 1552—8.Sánchez M., Anitua E., Andia I. Poor standardization in platelet-rich therapies hampers advancement. Arthroscopy. 2010; 26(6): 725—6.Anitua E., Sànchez M., Zalduendo M.M., de la Fuente M., Prado R., Orive G., Andia I. Fibroblastic response to treatment with different preparations rich in growth factors. Cell Prolif. 2009; 42(2): 162—70.Martinez-Zapata M.J., Marti-Carvajal A., Solà I., Bolibar I., Angel Expósito J., Rodriguez L., Garcia J. Efficacy and safety of the use of autologous plasma rich in platelets for tissue regeneration: a systematic review. Transfusion. 2009; 49(1): 44—56.Senet P., Bon F.X., Benbunan M., Bussel A., Traineau R., Calvo F., et al. Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers. J. Vasc. Surg. 2003; 38(6): 1342—8.Stammers A.H., Trowbridge C.C., Marko M., Woods E.L., Brindisi N., Pezzuto J., et al. Autologous platelet gel: fad or savoir? Do we really know? J. Extra Corpor. Technol. 2009; 41(4): P25—30.Sónchez M., Azofra J., Anitua E., Andia I., Padilla S., Santisteban J., Mujika I. Plasma rich in growth factors to treat an articular cartilage avulsion: a case report. Med. Sci. Sports Exerc. 2003; 35(10): 1648—52.Marx R.E., Carlson E.R., Eichstaedt R.M., Schimmele S.R., Strauss J.E., Georgeff K.R. Platelet-rich plasma: Growth factor enhancement for bone grafts. Oral. Surg. Oral. Med Oral. Pathol. Oral. Radiol. Endod. 1998; 85(6): 638—46.Whitlow J., Shackelford A., Sievert A., Sistino J. Barriers to the acceptance and use of autologous platelet gel. Perfusion. 2008; 23(5): 283—9.Whitman D.H., Berry R.L., Green D.M. Platelet gel: an autologous alternative to fibrin glue with applications in oral and maxillofacial surgery. J. Oral. Maxillofac. Surg. 1997; 55(11): 1294—9.Smith S.E., Roukis T.S. Bone and wound healing augmentation with platelet-rich plasma. Clin. Podiatr. Med. Surg. 2009; 26(4): 559—88.Weibrich G., Kleis W.K., Kunz-Kostomanolakis M., Loos A.H., Wagner W. Correlation of platelet concentration in platelet-rich plasma to the extraction method, age, sex, and platelet count of the donor. Int. J. Oral. Maxillofac Implants. 2001; 16(5): 693—9.Lemons P.P., Chen D., Whiteheart S.W. Molecular mechanisms of platelet exocytosis: requirements for alpha-granule release. Biochem. Biophys. Res. Commun. 2000; 267(3): 875—80.Yol S., Tekin A., Yilmaz H., Küçükkartallar T., Esen H., Caglayan O., Tatkan Y. Effects of platelet rich plasma on colonic anastomosis. J. Surg. Res. 2008; 146(2): 190—4.Marx R.E. Bone and bone graft healing. Oral. Maxillofac. Surg. Clin. North Am. 2007; 19(4): 455—66.Scevola S., Nicoletti G., Brenta F., Isernia P., Maestri M., Faga A. Allogenic platelet gel in the treatment of pressure sores: a pilot study. Int. Wound J. 2010; 7(3): 184—90.van der Hagen S.J., Baeten C.G., Soeters P.B., van Gemert W.G. Autologous platelet-derived growth factors (platelet-rich plasma) as an adjunct to mucosal advancement flap in high cryptoglandular perianal fistulae: a pilot study. Colorectal Dis. 2011; 13(2): 215—8.Persson U., Willis M., Odegaard K., Apelqvist J. The costeffectiveness of treating diabetic lower extremity ulcers with becaplermin (Regranex): a core model with an application using Swedish cost data. Value Health. 2000; 3(Suppl. 1): 39—46.Villela D.L., Santos V.L. Evidence on the use of platelet-rich plasma for diabetic ulcer: a systematic review.Growth Factors. 2010; 28(2): 111—6.Villela D.L., Santos V.L. Topical therapy of chronic leg ulcers with platelet-rich plasma: a systematic review of the literature. Paper presented at: WOCN 2010 Conference of the Wound Ostomy Continence Nurse Society. June 12—16, 2010; St. Louis, MO, USA.Senet P., Bon F.X., Benbunan M., Bussel A., Traineau R., Calvo F., et al. Randomized trial and local biological effect of autologous platelets used as adjuvant therapy for chronic venous leg ulcers. Vasc Surg. 2003; 38(6): 1342—8.Hom D.B., Linzie B.M., Huang T.C. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg. 2007; 9(3): 174—83.Trowbridge C.C., Stammers A.H., Woods E., Yen B.R., Klayman M., Gilbert C. Use of platelet gel and its effects on infection in cardiac surgery. J. Extra Corpor. Technol. 2005; 37(4): 381—6.Gardner M.J., Demetrakopoulos D., Klepchick P.R., Mooar P.A. The efficacy of autologous platelet gel in pain control and blood loss in total knee arthroplasty. An analysis of the haemoglobin, narcotic requirement and range of motion. Int. Orthop. 2007; 31(3): 309—13.Saap L.J., Donohue K., Falanga V. Clinical classification of bioengineered skin use and its correlation with healing of diabetic and venous ulcers. Dermatol. Surg. 2004; 30(8): 1095—100.Everts P.A., Devilee R.J., Brown Mahoney C., Eeftinck-Schattenkerk M., Box H.A., Knape J.T., van Zundert A. Platelet gel and fibrin sealant reduce allogeneic blood transfusions in total knee arthroplasty. Acta Anaesthesiol. Scand. 2006; 50(5): 593—9.Dougherty E.J. An evidence-based model comparing the cost-effectiveness of platelet-rich plasma gel to alternative therapies for patients with nonhealing diabetic foot ulcers. Adv. Skin Wound Care. 2008; 21(12): 568—75.Akingboye A.A., Giddins S., Gamston P., Tucker A., Navsaria H., Kyriakides C. Application of autologous derived-platelet rich plasma gel in the treatment of chronic wound ulcer: diabetic foot ulcer. J. Extra Corpor. Technol. 2010; 42(1): 20—9.Robson M.C., Phillips L.G., Lawrence W.T., Bishop J.B., Youngerman J.S., Hayward P.G., et al. The safety and effect of topically applied recombinant basic fibroblast growth factor on the healing of chronic pressure sores. Ann Surg. 1992; 216(4): 401—6.Kazakos K., Lyras D.N., Verettas D., Tilkeridis K., Tryfonidis M. The use of autologous PRP gel as an aid in the management of acute trauma wounds. Injury. 2009; 40(8): 801—5.Khalafi R.S., Bradford D.W., Wilson M.G. Topical application of autologous blood products during surgical closure following a coronary artery bypass graft. Eur. J. Cardio-thorac. Surg. 2008; 34(2): 360—4.Steenvoorde P., van Doorn L.P., Naves C., Oskam J. Use of autologous platelet-rich fibrin on hard-to-heal wounds. J. Wound Care. 2008; 17(2): 60—3.Saratzis N., Saratzis A., Melas N., Kiskinis D.J. Non-activated autologous platelet-rich plasma for the prevention of inguinal wound-related complications after endovascular repair of abdominal aortic aneurysms. Extra Corpor. Technol. 2008; 40(1): 52—6.Spyridakis M., Christodoulidis G., Chatzitheofilou C., Symeonidis D., Tepetes K. The role of the platelet-rich plasma in accelerating the wound-healing process and recovery in patients being operated for pilonidal sinus disease: preliminary results. World J. Surg. 2009; 33(8): 1764—9.Липницкий Е.М. Лечение трофических язв нижних конечностей. М.: Медицина. 2001: 5—7.Krull E.A. Chronic cutaneous ulcerations and impaired healing in human skin. J. Am. Acad. Dermatol. 1985; 12(2, Pt 2): 394— 401.Sànchez M., Anitua E., Orive G., Mujika I., Andia I. Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med. 2009; 39(5): 345—54.Schade V.L., Roukis T.S. Use of platelet-rich plasma with splitthickness skin grafts in the high-risk patient. Foot Ankle Spec. 2008; 1(3): 155—9.