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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Skin and Venereal Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Skin and Venereal Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский журнал кожных и венерических болезней</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1560-9588</issn><issn publication-format="electronic">2412-9097</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">321342</article-id><article-id pub-id-type="doi">10.17816/dv321342</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>DERMATOLOGY</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>ДЕРМАТОЛОГИЯ</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical case of psoriasis in an HIV-positive patient</article-title><trans-title-group xml:lang="ru"><trans-title>Клинический случай псориаза у ВИЧ-позитивного пациента</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0948-2419</contrib-id><name-alternatives><name xml:lang="en"><surname>Kleymenova</surname><given-names>Valeriya E.</given-names></name><name xml:lang="ru"><surname>Клейменова</surname><given-names>Валерия Евгеньевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>l120595444l@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9383-0745</contrib-id><contrib-id contrib-id-type="spin">5925-9031</contrib-id><name-alternatives><name xml:lang="en"><surname>Krinitsyna</surname><given-names>Yulia M.</given-names></name><name xml:lang="ru"><surname>Криницына</surname><given-names>Юлия Михайловна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д-р мед. наук, профессор</p></bio><email>julia407@yandex.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0379-7823</contrib-id><name-alternatives><name xml:lang="en"><surname>Pakhomova</surname><given-names>Vera V.</given-names></name><name xml:lang="ru"><surname>Пахомова</surname><given-names>Вера Владимировна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><email>vera9037@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Novosibirsk Regional Clinical Dermatovenerologic Dispensary</institution></aff><aff><institution xml:lang="ru">Новосибирский областной клинический кожно-венерологический диспансер</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Federal Research Center of Fundamental and Translational Medicine</institution></aff><aff><institution xml:lang="ru">Федеральный исследовательский центр фундаментальной и трансляционной медицины</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2023-05-27" publication-format="electronic"><day>27</day><month>05</month><year>2023</year></pub-date><pub-date date-type="pub" iso-8601-date="2023-06-22" publication-format="electronic"><day>22</day><month>06</month><year>2023</year></pub-date><volume>26</volume><issue>3</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>235</fpage><lpage>242</lpage><history><date date-type="received" iso-8601-date="2023-03-14"><day>14</day><month>03</month><year>2023</year></date><date date-type="accepted" iso-8601-date="2023-04-20"><day>20</day><month>04</month><year>2023</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2023, Eco-Vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2023, Эко-Вектор</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="en">Eco-Vector</copyright-holder><copyright-holder xml:lang="ru">Эко-Вектор</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2026-06-22"/></permissions><self-uri xlink:href="https://rjsvd.com/1560-9588/article/view/321342">https://rjsvd.com/1560-9588/article/view/321342</self-uri><abstract xml:lang="en"><p>Modern ideas about psoriasis are becoming wider, while the incidence of this dermatosis is increasing every year. Psoriasis does not seem to be just a skin pathological process, since the basis of this disease is the development of chronic systemic immune inflammation resulting from the launch of a complex cascade of immune reactions with impaired activity of T-lymphocytes and the production of various pro-inflammatory cytokines and chemokines.</p> <p>The course of psoriatic disease has its own characteristics in a patient with human immunodeficiency virus. The peculiarities of the course of psoriasis in a patient with human immunodeficiency virus require a personalized approach in therapy.</p> <p>This article describes a clinical case of psoriasis in a patient with newly diagnosed human immunodeficiency virus. The stages of the diagnostic search for HIV infection are described. To confirm the diagnosis of psoriasis, a pathohistological examination of a skin biopsy was performed, as well as additional laboratory and instrumental studies. The main features of the course of psoriatic disease in an HIV-positive patient are demonstrated: a combination of several clinical forms of the disease, severe severity, lack of necessary positive dynamics against the background of external and basic anti-inflammatory forms of therapy.</p></abstract><trans-abstract xml:lang="ru"><p>Современные представления о псориазе становятся всё шире, при этом заболеваемость данным дерматозом с каждым годом возрастает. На сегодняшний день псориаз не представляется только лишь кожным патологическим процессом, так как в основе данного заболевания лежит развитие хронического системного иммунного воспаления, возникающего в результате запуска сложного каскада иммунных реакций с нарушением активности T-лимфоцитов и продукцией различных провоспалительных цитокинов и хемокинов.</p> <p>Течение псориатической болезни имеет свои особенности у пациента с вирусом иммунодефицита человека, что требует персонифицированного подхода в терапии.</p> <p>В статье представлен клинический случай течения псориаза у пациента с впервые выявленным вирусом иммунодефицита человека. Описаны этапы диагностического поиска ВИЧ-инфекции. Для подтверждения диагноза псориаза выполнены патогистологическое исследование биоптата кожи, а также дополнительные лабораторные и инструментальные исследования. Продемонстрированы основные особенности течения псориатической болезни у ВИЧ-позитивного пациента: сочетание нескольких клинических форм заболевания; тяжёлая степень; отсутствие необходимой положительной динамики на фоне наружной и базисной противовоспалительной формы терапии.</p></trans-abstract><kwd-group xml:lang="en"><kwd>psoriasis</kwd><kwd>HIV-infection</kwd><kwd>case report</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>псориаз</kwd><kwd>ВИЧ-инфекция</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Kubanov АА, Bogdanova EV. Epidemiology of psoriasis among the elderly population and volume of specialized medical care provided to patients with psoriasis in the Russian Federation in 2010–2019. Vestnik Dermatologii i Venerologii. 2020;96(5):7–18. 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