Russian Journal of Skin and Venereal DiseasesRussian Journal of Skin and Venereal Diseases1560-95882412-9097Eco-Vector10908610.17816/dv109086Research ArticleExperience of using the 1,5% Tetranyl U cream in patients with tinea corporis and tinea crurisMaximovIvan S.<p>Assistant</p>maximov.is@mail.ruhttps://orcid.org/0000-0003-2850-2910PetukhovaEugenia V.<p>Student</p>petuxova0304@gmail.comhttps://orcid.org/0000-0002-9396-4874I.M. Sechenov First Moscow State Medical University (Sechenov University)230820222521511583006202208072022Copyright © 2022, Maximov I.S., Petukhova E.V.2022<p><em>BACKGROUND:</em> Over the past ten years, there has been a persistent increase in the resistance of dermatophytes to antifungal drugs. The development of new drugs and the evaluation of the effectiveness of medicines is a priority in mycology.</p>
<p><em>AIMS: </em>Evaluation of the effectiveness and safety of using the cream containing Tetranyl U and 10% urea in the treatment of tinea corporis and tinea cruris.</p>
<p><em>MATERIALS AND METHODS: </em>The study included 30 patients with a laboratory-confirmed diagnosis of tinea corporis and tinea cruris of mild to moderate severity. Patients were recommended to use the cream which was applied to the lesions 2 times a day for 3 weeks. The evaluation of the severity the course of mycosis and the effectiveness of the cream was carried out by calculating a 4-point PGA (Physician Global Assessment) before treatment and after 3 weeks of using the cream.</p>
<p><em>RESULTS: </em>According to the results of the study, the clinical efficacy was 81.8%. Mycological response (negative direct microscopy + mycological culture) was achieved in 82.8% of patients.</p>
<p><em>CONCLUSION: </em>The cream containing Tetranyl U showed good efficacy and tolerability in the treatment of tinea corporis and tinea cruris, which is confirmed by the results of clinical and microbiological studies.</p>dermatophytesskin mycosestinea corporistinea crurisTetranyl Uдерматофитымикоз гладкой кожиундециленовая кислотаTetranyl Uмикоз крупных складок[Tirado-Sánchez A, González GM, Bonifaz A. Endemic mycoses: epidemiology and diagnostic strategies. Expert Rev Anti Infect Ther. 2020;18(11):1105–1117. doi: 10.1080/14787210.2020.1792774][Sacheli R, Hayette MP. Antifungal resistance in dermatophytes: genetic considerations, clinical presentations and alternative therapies. J Fungi (Basel). 2021;7(11):983. doi: 10.3390/jof7110983][Havlickova B, Czaika VA, Friedrich M. Epidemiological trends in skin mycoses worldwide. Mycoses. 2008;51(Suppl 4):2–15. doi: 10.1111/j.1439-0507.2008.01606.x][Resources and activities of medical organizations of dermatovenerological profile. The incidence of sexually transmitted infections, infectious skin diseases and skin diseases for 2017–2018. (Statistical materials). Moscow; 2019. 208 p. (In Russ).][Monod M. Antifungal resistance in dermatophytes: Emerging problem and challenge for the medical community. J Mycol Med. 2019;29(4):283–284. doi: 10.1016/j.mycmed.2019.100913][Nenoff P, Verma SB, Vasani R, et al. The current Indian epidemic of superficial dermatophytosis due to Trichophyton mentagrophytes ― a molecular study. Mycoses. 2019;62(4):336–356. doi: 10.1111/myc.12878][Shi D, Zhao Y, Yan H, et al. Antifungal effects of undecylenic acid on the biofilm formation of Candida albicans. Int J Clin Pharmacol Ther. 2016;54(5):343–353. doi: 10.5414/CP202460][Mionić Ebersold M, Petrović M, Fong WK, et al. Hexosomes with Undecylenic acid efficient against Candida albicans. Nanomaterials (Basel). 2018;8(2):91. doi: 10.3390/nano8020091][Smith EB, Powell RP, Graham JL, Ulrich JA. Topical undecylenic acid in tinea pedis: a new look. Int J Dermatol. 1977;16(1):52–56. doi: 10.1111/j.1365-4362.1977.tb00741.x][Karpova OA. Mycostop ― an integrated approach to the treatment and prevention of onychomycosis. Advances in Medical Mycology. 2019;20:136–140. (In Russ).][Clinical recommendations of the Russian Society of Dermatovenerologists and Cosmetologists “Mycosis of the scalp, trunk, hands and feet”. Moscow; 2020. 53 р. (In Russ).]