Synthesis of New Condensed Derivatives of Thieno[3,2-d]-pyrimidines Based on 7,7-Dimethyl-2-mercapto-4-(2-furyl)-3-cyano-7,8-dihydro-5H-pyrano[4,3-b]pyridine

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Abstract

Methods for the synthesis of new condensed thieno[3,2-e]pyridines and thieno[3,2-d]pyrimidines have been developed. The reaction of 7,7-dimethyl-2-mercapto-4-(2-furyl)-3-cyano-7,8-dihydro-5H-pyrano[4,3-b]pyridine with chloroacetic acid amides has been established depending on temperature. It has been shown that at high temperatures alkylation and intramolecular cyclization (one pot reaction) occur with the formation of pyrano[4,3-b]thieno[3,2-e]pyridines. New derivatives of condensed tetracyclic thieno[3,2-d]pyrimidines were synthesized by condensation of pyrano[4,3-b]thieno[3,2-e]pyridine carboxamides with orthoformic acid triethyl ester.

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About the authors

V. V. Dabaeva

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Author for correspondence.
Email: valya.dabayeva@mail.ru
ORCID iD: 0000-0003-2980-2552
Armenia, 26, Azatutyan Ave., Yerevan, 0014

I. M. Barkhudaryants

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: valya.dabayeva@mail.ru
ORCID iD: 0000-0002-4620-6034
Armenia, 26, Azatutyan Ave., Yerevan, 0014

E. G. Paronikyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: valya.dabayeva@mail.ru
ORCID iD: 0000-0002-6048-3599
Armenia, 26, Azatutyan Ave., Yerevan, 0014

Sh. Sh. Dashyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: valya.dabayeva@mail.ru
ORCID iD: 0000-0002-6365-3725
Armenia, 26, Azatutyan Ave., Yerevan, 0014

M. R. Baghdasaryan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: valya.dabayeva@mail.ru
ORCID iD: 0000-0001-7092-0556
Armenia, 26, Azatutyan Ave., Yerevan, 0014

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