Monoclonal antibodies to a variable fragment of the T cell receptor – at the service of science and medicine
- Авторлар: Khokhlov V.P.1
-
Мекемелер:
- Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
- Шығарылым: Том 145, № 2 (2025)
- Беттер: 93-115
- Бөлім: Articles
- ##submission.dateSubmitted##: 10.07.2025
- ##submission.dateAccepted##: 10.07.2025
- ##submission.datePublished##: 10.07.2025
- URL: https://rjsvd.com/0042-1324/article/view/687227
- DOI: https://doi.org/10.31857/S0042132425020012
- EDN: https://elibrary.ru/GCYTFZ
- ID: 687227
Дәйексөз келтіру
Толық мәтін
Аннотация
This review summarizes recent progress in the engineering of monoclonal antibodies directed to a variable fragment of the T cell receptor with a given mode of action on the targeted subset of T lymphocytes. Since the unique T cell subsets are responsible for the development and outcome of many socially significant diseases the ability of monoclonal antibodies to deplete or expand pathogenetically important T cell families is of a grate interest in clinical practice. The review also discusses the role of the unique T cell families in the pathogenesis of a number of autoimmune and infectious diseases, which provides the prerequisites for the creation of highly effective targeted drugs based on monoclonal antibodies to a variable fragment of the T cell receptor.
Толық мәтін

Авторлар туралы
V. Khokhlov
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: med9000@mail.ru
Ресей, Moscow
Әдебиет тізімі
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